두경부 악성종양에 대한 MBD 유도화학요법의 임상적 고찰 = Clinical trial of MBD as Induction Chemotherapy for the Head and Neck Cancer

다국어 초록 (Multilingual Abstract)

40 patients with head and neck cancer received the induction chemotherapy with methotrexate, bleomycin and cis-platinum (MBD) between January, 1988 and December, 1991.
The results were as follows.
1) Among a total of 40 cases, 26 cases(65%) showed objective remission(complete remission 3cases, partial remission 23 cases).
2) Remission rates related to various primary tumor sites revealed that the oral cavity and larynx had relatively higher remission rate followed by the hypopharynx, the oropharynx and the nasopharynx.
3) There was no significant difference in the response rate according to patient characteristics such as primary tumor site, the degree of differentiation of tumor cells or stage of tumor.
4) This regimen (MBD) of induction chemotherapy produced only mild toxic reactions such as nausea and vomiting, mucositis and diarrhea, leukopenia and thrombocytopenia, ototoxicity, and nephrotoxicity. These reactions were easily controlled.