This experiment was performed to study the effect of the arachidonic acid metabolites(PGE_2, LTB_4, HETEs) on the bone resorption in the organ culture.
The observed results were as follows:
1. PGE_2, at concentration of 10^-6M, increased ^45Ca relea...
This experiment was performed to study the effect of the arachidonic acid metabolites(PGE_2, LTB_4, HETEs) on the bone resorption in the organ culture.
The observed results were as follows:
1. PGE_2, at concentration of 10^-6M, increased ^45Ca release significantly after 72 hours of culture.
2. LTB_4 or HETEs, at all concentrations, had no effect on the bone resorption after 72 hours of culture.
3. LTB_4 or HETEs did not change the bone resorbing activity of PGE_2 bone resorption after 72 hours of culture.