난황 유래 인지질로 합성한 리포좀의 물리적 특성과 안정성 = Physical Property and Stability of Liposome Prepared from Egg Yolk Phospholipids at Various Storage Conditions

다국어 초록 (Multilingual Abstract)

Liposomes were prepared from egg yolk phospholipids to study their physical properties and stability at various storage
conditions. Under storage conditions at different pH levels, the particle sizes of liposomes increased at the range of pH 1-2,
and the absolute values of ζ-potentials were reduced at the range of pH 1-4. The leakage of sulforhodamine B (SRB), a
fluorescent dye which is encapsulated in the liposome, increased greatly at pH 2-4. At different storage temperatures, the
particle size of liposomes increased from the 10 days of storage at 4oC and the 40 days at 20 and 35oC. The ζ-potentials
decreased slightly later during storage under 4, 20 and 35oC. At the storage temperature of 50oC, the leakage of SRB was
the greatest. Therefore, we concluded that the pH conditions lower than pH 6 and high temperature of 50oC are not conducive
to storing liposomes. The results obtained here may prove helpful in developing liposome-based encapsulation and
diagnostic reagents

다국어 초록 (Multilingual Abstract)

Liposomes were prepared from egg yolk phospholipids to study their physical properties and stability at various storage
conditions. Under storage conditions at different pH levels, the particle sizes of liposomes increased at the range of pH 1-2,
and the absolute values of ζ-potentials were reduced at the range of pH 1-4. The leakage of sulforhodamine B (SRB), a
fluorescent dye which is encapsulated in the liposome, increased greatly at pH 2-4. At different storage temperatures, the
particle size of liposomes increased from the 10 days of storage at 4oC and the 40 days at 20 and 35oC. The ζ-potentials
decreased slightly later during storage under 4, 20 and 35oC. At the storage temperature of 50oC, the leakage of SRB was
the greatest. Therefore, we concluded that the pH conditions lower than pH 6 and high temperature of 50oC are not conducive
to storing liposomes. The results obtained here may prove helpful in developing liposome-based encapsulation and
diagnostic reagents

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