선천성 고혈압 성장 백서에서의 카테콜아민 합성효소에 관한 연구 = Catecholamine Synthesizing Enzymes in Adult Spontaneously Hypertensive Rats

다국어 초록 (Multilingual Abstract)

Central catecholaminergic nerves have an integral place in the central connections of the autonomic nervous system. It has long been thought that sympathetic nervous system plays an importantpart in the regulation of blood pressure, but there is no firm evidence of excessive activity of the sympathetic nervous system in development and maintenance of essential hypertension.
It seems clear that central catecholaminergic systems participate in the regulation of normal blood pressure. However, it is not yet clear which system is altered in hypertension and which changes are of primary causal importance and which are secondary in nature.
In the present study, we investigated activities of catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine β-hydroxylase (DBH), phenylethanolamine N-methyl transferase (PNMT) in various regions of the brain and the adrenals in spontaneous hypertensive (SH) and normotensive wistar rats at 16 weeks of age when the hypertension is fixed. TH, DBH and PNMT activities n the adrenal glands of SH rats were significantly higher than that those of normotensive wistar rats. TH activity was higher in the hypothalamus of SH rats than that of wistar control rats. In the medulla, DBH activity of SH rats was lower than that of wistar rats. But PNMT activity was higher in the medulla of SH rats than that of wistar rats.
These results suggest the possibility of over-activity of the adrenal medulla of SH rats and a participation of both norepinephrine and epinephrine neurons in the maintenance of hypertension. (J. Kor Soc Endocrinol 4:231~239, 1989)