본 연구에서는 생물학적 공유결합인 다이타이로신 결합을 모방하여 비가역적 공유결합을 기반으로 한 펩타이드의 자기조립 방법을 연구하였다. 고밀도의 다이타이로신 결합을 달성하기 위...
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https://www.riss.kr/link?id=A107255212
2021
-
Peptide ; Assembly ; Tyrosine ; Dityrosine ; Photo crosslink
KCI등재,SCOPUS,ESCI
학술저널
112-117(6쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
본 연구에서는 생물학적 공유결합인 다이타이로신 결합을 모방하여 비가역적 공유결합을 기반으로 한 펩타이드의 자기조립 방법을 연구하였다. 고밀도의 다이타이로신 결합을 달성하기 위...
본 연구에서는 생물학적 공유결합인 다이타이로신 결합을 모방하여 비가역적 공유결합을 기반으로 한 펩타이드의 자기조립 방법을 연구하였다. 고밀도의 다이타이로신 결합을 달성하기 위해 Tyr-Tyr-Leu-Tyr-Tyr (YYLYY) 의 서열을 갖는 펩타이드 단량체를 선택하였다. 다이타이로신 결합으로 자기조립 된 펩타이드 나노입자는 가시광선 하에서 Ru(BPY)<sub>3</sub>Cl<sub>2</sub> 촉매를 사용하여 단일공정 광가교를 통해 합성되었다. 펩타이드 나노 입자의 크기에 대한 각 성분의 농도 효과는 동적 광산란, UV-Vis 분광법 및 투과 전자 현미경을 사용하여 확인하였다. 이를 통해 130 nm~350 nm범위의 펩타이드 나노입자의 크기별 최적의 합성 조건을 제시하였다.
다국어 초록 (Multilingual Abstract)
In this study, a method of self-assembly of peptides based on irreversible covalent bonds was studied by mimicking a biological covalent bond, dityrosine bond. A tyrosine-rich short peptide monomer having the sequence of Tyr-Tyr-Leu-Tyr-Tyr (YYLYY) wa...
In this study, a method of self-assembly of peptides based on irreversible covalent bonds was studied by mimicking a biological covalent bond, dityrosine bond. A tyrosine-rich short peptide monomer having the sequence of Tyr-Tyr-Leu-Tyr-Tyr (YYLYY) was selected to achieve a high-density of dityrosine bond. The peptide nanoparticles covalently self-assembled with dityrosine bonds were synthesized by one-step photo-crosslinking of a peptide using a ruthenium catalyst under visible light. The effect of the concentration of each component for the size of the peptide nanoparticle was studied using dynamic light scattering, UV-Vis spectroscopy, and transmission electron microscopy. As a result, the synthesis conditions for size of the peptide nanoparticles ranging from 130 nm to 350 nm were optimized.
참고문헌 (Reference)
1 Lehrer, S. S., "Ultraviolet Irradiation Effects in Poly-L-tyrosine and Model Compounds. Identification of Bityrosine as a Photoproduct" 6 (6): 757-767, 1967
2 Correia, M, "UV-light Exposure of Insulin: Pharmaceutical Implications Upon Covalent Insulin Dityrosine Dimerization and Disulphide Bond Photolysis" 7 (7): e50733-, 2012
3 Elvin, C. M., "Synthesis and Properties of Crosslinked Recombinant Pro-resilin" 437 (437): 999-1002, 2005
4 Cui, H., "Self-assembly of Peptide Amphiphiles: From Molecules to Nanostructures to Biomaterials" 94 (94): 1-18, 2010
5 Baek, K., "Self-assembly of Nanostructured Materials Through Irreversible Covalent Bond Formation" 48 (48): 2221-2229, 2015
6 Mann, S., "Self-assembly and Transformation of Hybrid Nanoobjects and Nanostructures Under Equilibrium and Non-equilibrium Conditions" 8 (8): 781-792, 2009
7 Burrows, M., "Resilin and Chitinous Cuticle form a Composite Structure for Energy Storage in Jumping by Froghopper Insects" 6 (6): 41-, 2008
8 Hu, X., "Recent Advances in Short Peptide Self-assembly: from Rational Design to Novel Applications" 45 : 1-13, 2020
9 Lim, Y., "Recent Advances in Functional Supramolecular Nanostructures Assembled from Bioactive Building Blocks" 38 (38): 925-934, 2009
10 Ding, Y., "Photo-cross-Linking Approach to Engineering Small Tyrosine-containing Peptide Hydrogels with Enhanced Mechanical Stability" 29 (29): 13299-13306, 2013
1 Lehrer, S. S., "Ultraviolet Irradiation Effects in Poly-L-tyrosine and Model Compounds. Identification of Bityrosine as a Photoproduct" 6 (6): 757-767, 1967
2 Correia, M, "UV-light Exposure of Insulin: Pharmaceutical Implications Upon Covalent Insulin Dityrosine Dimerization and Disulphide Bond Photolysis" 7 (7): e50733-, 2012
3 Elvin, C. M., "Synthesis and Properties of Crosslinked Recombinant Pro-resilin" 437 (437): 999-1002, 2005
4 Cui, H., "Self-assembly of Peptide Amphiphiles: From Molecules to Nanostructures to Biomaterials" 94 (94): 1-18, 2010
5 Baek, K., "Self-assembly of Nanostructured Materials Through Irreversible Covalent Bond Formation" 48 (48): 2221-2229, 2015
6 Mann, S., "Self-assembly and Transformation of Hybrid Nanoobjects and Nanostructures Under Equilibrium and Non-equilibrium Conditions" 8 (8): 781-792, 2009
7 Burrows, M., "Resilin and Chitinous Cuticle form a Composite Structure for Energy Storage in Jumping by Froghopper Insects" 6 (6): 41-, 2008
8 Hu, X., "Recent Advances in Short Peptide Self-assembly: from Rational Design to Novel Applications" 45 : 1-13, 2020
9 Lim, Y., "Recent Advances in Functional Supramolecular Nanostructures Assembled from Bioactive Building Blocks" 38 (38): 925-934, 2009
10 Ding, Y., "Photo-cross-Linking Approach to Engineering Small Tyrosine-containing Peptide Hydrogels with Enhanced Mechanical Stability" 29 (29): 13299-13306, 2013
11 Santisa, E. D., "Peptide Self-assembly for Nanomaterials: the Old New Kid on the Block" 44 (44): 8288-8300, 2015
12 Luo, T., "Noncovalent Modulation of the Inverse Temperature Transition and Self-assembly of Elastin-b-Collagenlike Peptide Bioconjugates" 137 (137): 15362-15365, 2015
13 Okesola, B. O., "Multicomponent Self-assembly as a Tool to Harness New Properties from Peptides and Proteins in Material Design" 47 (47): 3721-3736, 2018
14 Zhang, D., "High Water Content Silk Protein-based Hydrogels with Tunable Elasticity Fabricated via a Ru(II) Mediated Photochemical Cross-linking Method" 18 (18): 1831-1840, 2017
15 Malencik, D. A., "Dityrosine: Preparation, Isolation, and Analysis" 242 (242): 202-213, 1996
16 Partlow, B. P., "Dityrosine Cross-linking in Designing Biomaterials" 2 (2): 2108-2121, 2016
17 Min, K. I., "Direct Synthesis of a Covalently Self-Assembled Peptide Nanogel from a Tyrosine-Rich Peptide Monomer and Its Biomineralized Hybrids" 130 (130): 5732-5736, 2018
18 Min, K. I., "Covalent Self-assembly and One-step Photocrosslinking of Tyrosine-rich Oligopeptides to form Diverse Nanostructures" 55 (55): 6925-6928, 2016
19 Fancy, D. A., "Chemistry for the Analysis of Protein–protein Interactions: Rapid and Efficient Cross-linking Triggered by Long Wavelength Light" 96 (96): 6020-6024, 1999
고분자전해질 연료전지 열화 분석방법에 의한 PEM 수전해 열화 평가
PEMFC 고분자 막의 Short 저항 및 Shorting에 관한 연구
PEMFC Cathode 산소 조건에서 전극 촉매 내구성 평가
Cathode 산소 공급조건에서 고분자막 내구평가 프로토콜의 가습/건조 시간 변화의 영향
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
2013-01-01 | 평가 | 등재 1차 FAIL (등재유지) | |
2010-12-02 | 학술지명변경 | 한글명 : 화학공학 -> Korean Chemical Engineering Research(HWAHAK KONGHAK) | |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-08-25 | 학술지명변경 | 외국어명 : Korean Chem. Eng. Res. -> Korean Chemical Engineering Research | |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-09-27 | 학회명변경 | 영문명 : The Korean Institute Of Chemical Engineers -> The Korean Institute of Chemical Engineers | |
2006-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2001-07-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
1999-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.43 | 0.43 | 0.4 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.37 | 0.35 | 0.496 | 0.11 |