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https://www.riss.kr/link?id=A19704000
1993
-
500
학술저널
50-58(9쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Theophylline is widely used in pediatric patients for the treatment of asthma and neonatal apnea. To achieve adequate bronchodilation and avoid toxicity, it is generally accepted that the serum theophylline concentration should be maintained between 1...
Theophylline is widely used in pediatric patients for the treatment of asthma and neonatal apnea. To achieve adequate bronchodilation and avoid toxicity, it is generally accepted that the serum theophylline concentration should be maintained between 10 and 20㎍/ml. Concentrations greater than 20㎍/ml are associated with an increased incidence of toxicity. Clinical effectiveness and toxicity are clearly related to the serum concentrations. Thus, it is important to understand factors which might alter theophylline pharmacokinetics. Prednisolone has been reported to both increase and decrease theophylline serum concentrations. Clinical experience at our hospital (one case) suggested that there might be an interaction between prednisolone and theophylline that can potentially results in clinically significant changes in theophylline serum concentrations. Thus, we studied eleven asthmatic children, who were admitted to our hospital and received oral sustained release theophylline and prednisolone. The mean serum theophylline concentration of single therapy group (phase 1) was 8.10㎍/ml and of concomitant administered prednisolone group (phase 2) was 8.39㎍/ml. On basis of serum theophylline concentrations, we had taken the volume of distribution (Vd), half life (t1/2) and calculated clearance (Cl), in each of phase 1 and 2. The mean clearance of phase 1 was 67.37ml/㎏/hr and of phase 2 was 67.85ml/㎏/hr. The difference between mean serum theophylline concentration and clearance in the single therapy group (phase 1) compared with concomitant administered prednisolone therapy group (phase 2) was not statistically significant. (p>0.05) This suggests that prednisolone does not affect the metabolism of theophylline and does not alter serum concentration of theophylline.
국민학교 아동 가족의 흡연 실태와 흡연이 아동의 호흡기 질환 및 증상에 미치는 영향
만성 또는 재발성 감염 환아의 혈청 IgG - 아형 농도
기관지천식 환아에서 EPA / DCHA 의 투여가 임상경과 및 기도반응에 미치는 영향
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