Advanced glycation end products and their receptors did not show any association with body mass parameters in metabolically healthy adolescents

다국어 초록 (Multilingual Abstract)

We determined the relationship between circulating advanced glycation end products (AGEs), AGE receptors and homeostatic model assessment for insulin resistance (HOMA‐IR) in metabolically healthy obese and normal weight adolescents.
In 2015, we recruited 80 normal weight adolescents and 80 with obesity from schools Leon city, Mexico, and put them into metabolically healthy (HOMA‐IR <3.0) and unhealthy (HOMA‐IR >3.0) groups. We measured their body mass index (BMI) and carried out detailed blood analyses.
We found a higher triglycerides, triglycerides/high‐density lipoproteins cholesterol (TG/HDL‐C) index, HOMA‐IR, tumour necrosis factor alpha (TNF‐α) and interleukin‐6 (IL‐6) in the metabolically healthy group and found correlations between HOMA‐IR with BMI, the TG/HDL‐C index and IL‐6 and the TG/HDL‐C index and BMI and (TNF‐α). There was no correlation between markers of obesity and circulating N‐carboxymethyl‐lysine (CML) or soluble receptor for advanced glycation end products (sRAGE). Some unhealthy adolescents had higher CML (15.5 ± 2.7 U/mL, p < 0.028) and sRAGE (3123 ± 1364 pg/mL, p < 0.001) than the healthy group.
HOMA‐IR and the TG/HDL‐C index were associated with BMI and inflammation markers. CML and sRAGE were not associated with obesity or inflammation. These parameters were higher in unhealthy obese adolescents.