Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome = Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome

다국어 초록 (Multilingual Abstract)

Background/Aims: Oxidative stress increases the risk of cardiovascular compli-cations of metabolic syndrome (MetS). This study was conducted to examine the difference in antioxidant capacity according to the presence of MetS, and to char-acterize the association between antioxidant capacity and MetS-related factors. Methods: We used the biological antioxidant potential (BAP) test to estimate antioxidant capacity. The BAP test has recently been used as an indicator of an-tioxidant capacity. We measured BAP levels in 45 patients with MetS (mean age, 44.6 ± 1.1 years) and 47 age- and sex-matched controls (mean age, 42.7 ± 1.1 years). To evaluate the association between antioxidant capacity and MetS, adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis fac-tor- α, and homeostatic model assessment for insulin resistance (HOMA-IR), lin-ear regression and logistic analyses were performed. Results: The mean BAP of the MetS group (1,937.3 ± 36.5 μmol/L) was significantly lower than that of the non-MetS group (2,101.7 ± 29.5 μmol/L). Also, the mean BAP was low in persons having low high density lipoprotein and high triglyceride. Reduced antioxidant capacity was significantly associated with adiponectin, HO-MA- IR and hs-CRP after adjusting for age and sex. The odds ratios for MetS with BAP, log adiponectin, log HOMA-IR, and log hs-CRP were 0.63 (95% confidence interval [CI], 0.49 to 0.82), 0.22 (0.10 to 0.51), 14.24 (4.35 to 46.58), and 1.93 (1.36 to 2.75), respectively. Conclusions: Persons with MetS showed reduced antioxidant capacity. We identi- fied relationships between antioxidant capacity measured by BAP test and MetS, as well as MetS-related factors, such as insulin resistance, hs-CRP, and adiponectin.