Trends in Bacteria Causing Diarrheal Infection from 2010 to 2018 in Cheonan, Korea: Aeromonas spp., Campylobacter spp., and Clostridioides spp.

다국어 초록 (Multilingual Abstract)

Diarrhea is one of the most common infectious diseases known worldwide. However, few studies have examined anaerobic diarrhea-causing bacteria (DB), which are difficult to culture. Recent advances in molecular biology have facilitated the detection and analysis of anaerobic DB. In this study, long-term trends in anaerobic DB were evaluated in Korea. From 2010 to 2018, symptoms of diarrhea reported were analyzed among patients hospitalized at the Dankook University Hospital in Korea. Results of multiplex polymerase chain reaction based on seasonality, age, overlapping infection, and other factors in patients were evaluated. DB were detected in 38.2% of 1716 stool specimens in the duration of the study. Of the pathogens detected using this method, 49.8% (n = 405/813) were anaerobic bacteria, including Clostridioides perfringens, Campylobacter spp., Clostridioides difficile toxin B, and Aeromonas spp. Among the four anaerobic bacteria, Clostridioides perfringens was the most commonly occurring (15.5%; n = 126/813). Detection rates of Clostridioides perfringens, Clostridioides difficile toxin B, and Aeromonas spp. were 34.1% (n = 22/ 55), 34.9% (n = 43/126), and 40.0% (n = 38/109), respectively. The detection rate of Campylobacter spp. (32.7%; n = 37/115) was the highest in patients between 10 and 20 years of age. The detection rate of anaerobic DB showed an increase in 2018 as compared with that in 2010, and the number of events of diarrhea caused by anaerobic DB also increased in this duration. Further studies are required to devise methods that might prevent the proliferation of anaerobic D

참고문헌 (Reference)

1 유창범, "식중독" 대한의사협회 54 (54): 617-626, 2011

2 이승옥, "다중 중합효소연쇄반응법을 이용한 급성 감염성 설사의 원인세균 13종 및 바이러스 5종 검출" 대한임상미생물학회 16 (16): 33-38, 2013

3 Foodborne Disease Burden Epidemiology Reference Group, "WHO estimates of the global burden of foodborne diseases"

4 Oh YH, "Use of polymerase chain reaction and serum antibodies for diagnosis of enterohemorrhagic Escherichia coli" 33 : 99-110, 1988

5 KCDC, "The Prevalence and Characteristics of Bacteria causing Acute Diarrhea in Korea"

6 Bhavnani D, "Synergistic effects between rotavirus and coinfecting pathogens on diarrheal disease: evidence from a communitybased study in northwestern Ecuador" 176 : 387-395, 2012

7 정무상, "Multiplex PCR을 이용한 제주도 성인의 급성 설사 원인체에 관한 역학조사" 대한임상미생물학회 21 (21): 1-7, 2018

8 Geissler AL, "Increasing Campylobacter infections, outbreaks, and antimicrobial resistance in the United States, 2004-2012" 65 : 1624-1631, 2017

9 Chitnis AS, "Epidemiology of community-associated Clostridioides difficile infection, 2009 through 2011" 173 : 1359-1367, 2013

10 Clarke LE, "Enteritis necroticans with midgut necrosis caused by Clostridioides perfringens" 129 : 557-560, 1994

11 조성학, "Enteric Bacteria Isolated from Acute Diarrheal Patients in the Republic of Korea between the Year 2004 and 2006" 한국미생물학회 46 (46): 325-330, 2008

12 Lindsay B, "Diarrheagenic pathogens in polymicrobial infections" 17 : 606-611, 2011

13 Lee J, "Detection of bacterial and viral pathogens in stool specimens using multiplex PCR" 37 : 141-147, 2015

14 Fan H, "Co-detection of five species of waterborne bacteria by multiplex PCR" 5 : 47-54, 2008

15 Centers for Disease Control, "Clostridioides perfringens"

16 Acheson D, "Campylobacter jejuni infections:update on emerging issues and trends" 32 : 1201-1206, 2001

17 Randremanana RV, "Campylobacter infection in a cohort of rural children in Moramanga, Madagascar" 14 : 372-, 2014

18 World Health Organization, "Campylobacter"

19 CDC, "Campylobacter"

20 Government of Canada, "C-EnterNet"

21 Khamrin P, "A single-tube multiplex PCR for rapid detection in feces of 10 viruses causing diarrhea" 173 : 390-393, 2011

22 김난옥, "2012년도 우리나라 급성설사질환 유발 원인 세균의 분리현황 및 특성" 대한임상미생물학회 16 (16): 174-181, 2013