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      Efficacy of ginger for treating Type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials

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      https://www.riss.kr/link?id=A104511117

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      다국어 초록 (Multilingual Abstract)

      Background/Purpose: Few clinical trials have investigated the antidiabetic effects of ginger to date. Several recent clinical trials published in 2013 and 2014, although small, have added contradictory but compelling new evidence about the use of gin...

      Background/Purpose: Few clinical trials have investigated the antidiabetic effects of ginger to date.
      Several recent clinical trials published in 2013 and 2014, although small, have added contradictory but compelling new evidence about the use of ginger in treating diabetes in humans. Therefore, a systematic review and meta-analysis was conducted to clarify the evidence for using ginger to treat diabetes.
      Methods: Five randomized clinical trials (RCTs) were identified and included in the meta-analysis. Four of the RCTs were considered high quality and lasted 8 weeks; one lasted only 30 days and was considered low quality. Outcomes measured included fasting blood glucose and insulin, homeostatic model assessment (HOMA)-insulin resistance (IR), and hemoglobin A1c (HbA1c) levels, and were assessed as mean differences in the meta-analysis.
      Results: Ginger supplementation significantly lowered fasting blood glucose concentrations and HbA1c levels, but did not significantly lower fasting blood insulin or HOMA-IR.
      Conclusion: Ginger root supplementation significantly lowers blood glucose and HbA1c levels. When combined with dietary and lifestyle interventions it may be an effective intervention for managing Type 2 diabetes mellitus.

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      참고문헌 (Reference)

      1 Halban PA, "bcell failure in type 2 diabetes : postulated mechanisms and prospects for prevention and treatment" 99 : 1983-1992, 2014

      2 Khandouzi N, "The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients" 14 : 131-140, 2015

      3 Mozaffari-Khosravi H, "The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: A randomized, double-blind, placebocontrolled trial" 22 : 9-16, 2014

      4 Arablou T, "The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus" 65 : 515-520, 2014

      5 Heitmann K, "Safety of ginger use in pregnancy : results from a large population-based cohort study" 69 : 269-277, 2013

      6 Shalaby MA, "Safety and efficacy of Zingiber officinale roots on fertility of male diabetic rats" 48 : 2920-2924, 2010

      7 Li Y, "Preventive and protective properties of Zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review" 516870-, 2012

      8 Kahn SE, "Pathophysiology and treatment of type 2diabetes: Perspectives on the past, present, and future" 383 : 1068-1083, 2014

      9 Madkor HR, "Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycemia, dyslipidemia, and oxidative stress in streptozotoxcin-nicotinamide diabetic rats" 105 : 2010-2017, 2010

      10 Choudhari SS, "Identification of bioactive compounds of zingiber officinale roscoe rhizomes through gas chromatography and mass spectrometry" 5 : 16-20, 2013

      1 Halban PA, "bcell failure in type 2 diabetes : postulated mechanisms and prospects for prevention and treatment" 99 : 1983-1992, 2014

      2 Khandouzi N, "The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients" 14 : 131-140, 2015

      3 Mozaffari-Khosravi H, "The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: A randomized, double-blind, placebocontrolled trial" 22 : 9-16, 2014

      4 Arablou T, "The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus" 65 : 515-520, 2014

      5 Heitmann K, "Safety of ginger use in pregnancy : results from a large population-based cohort study" 69 : 269-277, 2013

      6 Shalaby MA, "Safety and efficacy of Zingiber officinale roots on fertility of male diabetic rats" 48 : 2920-2924, 2010

      7 Li Y, "Preventive and protective properties of Zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review" 516870-, 2012

      8 Kahn SE, "Pathophysiology and treatment of type 2diabetes: Perspectives on the past, present, and future" 383 : 1068-1083, 2014

      9 Madkor HR, "Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycemia, dyslipidemia, and oxidative stress in streptozotoxcin-nicotinamide diabetic rats" 105 : 2010-2017, 2010

      10 Choudhari SS, "Identification of bioactive compounds of zingiber officinale roscoe rhizomes through gas chromatography and mass spectrometry" 5 : 16-20, 2013

      11 Guariguata L, "Global estimates of diabetes prevalence for 2013 and projections for 2035" 103 : 137-149, 2014

      12 Li Y, "Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubules" 78 : 1549-1555, 2012

      13 "Ginger"

      14 Ensminger AH, "Foods & nutrition encyclopedia" Pegus Press 1983

      15 Mahluji S, "Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients" 64 : 682-686, 2013

      16 Andallu B, "Effect of aswagandha, ginger and mulberry on hyperglycemia and hyperlipidemia" 58 : 1-7, 2003

      17 Chen H, "Cysteine-conjugated metabolite of ginger component-shogaol serves as a carrier of-shogaol in cancer cells and in mice" 26 : 976-985, 2013

      18 Md. Shahidul Islam, "Comparative Effects of Dietary Ginger (Zingiber officinale) and Garlic (Allium sativum) Investigated in a Type 2 Diabetes Model of Rats" 한국식품영양과학회 11 (11): 152-159, 2008

      19 Higgins JP, "Cochrane handbook for systematic reviews of interventions" Cochrane Collaboration 187-241, 2011

      20 Chen H, "Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by-shogaol" 57 : 447-458, 2013

      21 Abdulrazaq NB, "Beneficial effects of ginger(Zingiber officinale)on carbohydrate metabolism in streptozotocininduced diabetic rats" 108 : 1415-1428, 2011

      22 Singh AB, "Anti-hyperglycemic, lipid lowering, and anti-oxidant properties of [6]-gingerol in db/db mice" 1 : 536-544, 2009

      23 Ojewole JAO, "Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (roscoe) rhizomes (zingiberaceae) in mice and rats" 20 : 764-772, 2006

      24 Rahmani AH, "Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities" 6 : 125-136, 2014

      25 Viljoen E, "A systematic review and metaanalysis of the effect and safety of ginger in the treatment of pregnancyassociated nausea and vomiting" 13 : 20-, 2014

      26 Rong X, "A 35-day gavage safety assessment of ginger in rats" 54 : 118-123, 2009

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2021 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-12-01 평가 등재 탈락 (해외등재 학술지 평가)
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.87 1.87 0
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0 0 0 0.58
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