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Procainamide is the drug of second choice (after lidocaine) in most coronary care units for the treatment of sustained ventricular arrhythmias associated with acute myocardial infarction. The purpose of this study was to develop the efficient assay me...
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RISS 인기검색어
프로카인아미드의 HPLC 분석법 및 한국인에서의 약동학적 특징 = HPLC Determination and Pharmacokinetic Profile of Procainamidein Korean Subjects
한글로보기https://www.riss.kr/link?id=A100399049
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2005
-
작성언어
-
- 주제어
-
KDC
518
-
등재정보
KCI등재
-
자료형태
학술저널
- 발행기관 URL
-
수록면
193-197(5쪽)
-
KCI 피인용횟수
0
- 제공처
- 소장기관
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
Procainamide is the drug of second choice (after lidocaine) in most coronary care units for the treatment of sustained ventricular arrhythmias associated with acute myocardial infarction. The purpose of this study was to develop the efficient assay method of procainamide in human plasma and to assess the pharmacokinetic profile of procainamide in healthy Korean volunteers. The pharmacokinetics of procainamide administered orally was evaluated after a dose of 250 mg. Procainamide in plasma was assayed using a specific HPLC method with UV absorbance at 275nm. AUC was 4.58±0.90 μg/ml.hr, Cmax 1.34±0.39 μg/ml, Tmax 1.06±0.34 hr and half-life 3.07±0.34 hr. Tmax was slightly shorter than that in Caucasian (1~2hr), whereas the half-life was similar to that in Caucasian (2.5~4.1 hr).
참고문헌 (Reference)
1 "clinical pharmacology and efficacy against ventricular arrhythmias. Ann. N. Y. Acad. Sci. 432" 1984
2 "Reverse-phase liquid chromatography method for measurment of procainamide and three metabolites in serum and urine precent of dose excreted as deethyl metabolites. J. Pharm. Sci. 76" 1987
3 "Procainamide and N-acetylprocainamide kinetics investigated simultaneously with stable isotype meth- odology. Clin. Pharmacol. Ther. 22" s. : 1977
4 "Polymorphic acetylation procainamide in man. Clin. Pharmacol. Ther. 17" 1975
5 "N-Acetylpro- cainamide levels in patients with end-stage renal failure. Clin. Pharmacol. Ther. 19" 1976
6 "Metabolism of procainamide in patients with chronic heart failure" 1978
7 "Metabolism of procainamide in normal and cardiac subjects. Clin. Pharmacol. Ther. 19" 1976
8 "Kinetics od procainamide and N-acetylprocain- amide in renal failure. Kidney Int. 12" 1977
9 "Improved high-performance liquid chromatographic assy for the determination of procainamide and its N-acetylated metabolite in plasma application to a single-dose pharmacokinetics study. J. Chromatogr. Sci. 36" 36 : 1998
10 "Elimination of procainamide in end stage renal failure. Clin. Pharmacol. Ther. 17" 1975
1 "clinical pharmacology and efficacy against ventricular arrhythmias. Ann. N. Y. Acad. Sci. 432" 1984
2 "Reverse-phase liquid chromatography method for measurment of procainamide and three metabolites in serum and urine precent of dose excreted as deethyl metabolites. J. Pharm. Sci. 76" 1987
3 "Procainamide and N-acetylprocainamide kinetics investigated simultaneously with stable isotype meth- odology. Clin. Pharmacol. Ther. 22" s. : 1977
4 "Polymorphic acetylation procainamide in man. Clin. Pharmacol. Ther. 17" 1975
5 "N-Acetylpro- cainamide levels in patients with end-stage renal failure. Clin. Pharmacol. Ther. 19" 1976
6 "Metabolism of procainamide in patients with chronic heart failure" 1978
7 "Metabolism of procainamide in normal and cardiac subjects. Clin. Pharmacol. Ther. 19" 1976
8 "Kinetics od procainamide and N-acetylprocain- amide in renal failure. Kidney Int. 12" 1977
9 "Improved high-performance liquid chromatographic assy for the determination of procainamide and its N-acetylated metabolite in plasma application to a single-dose pharmacokinetics study. J. Chromatogr. Sci. 36" 36 : 1998
10 "Elimination of procainamide in end stage renal failure. Clin. Pharmacol. Ther. 17" 1975
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분석정보
인용정보 인용지수 설명보기
학술지 이력
| 연월일 | 이력구분 | 이력상세 | 등재구분 |
|---|---|---|---|
| 2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
| 2021-01-01 | 평가 | 등재학술지 유지 (재인증) | |
| 2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
| 2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) |  |
| 2002-01-01 | 평가 | 등재후보학술지 유지 (등재후보1차) | |
| 1999-07-01 | 평가 | 등재후보학술지 선정 (신규평가) | |
학술지 인용정보
| 기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
|---|---|---|---|
| 2016 | 0.2 | 0.2 | 0.22 |
| KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
| 0.23 | 0.18 | 0.403 | 0.02 |
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