운동에 따른 MDA 및 SOD, GPx, CAT와 면역기능의 변화 고찰 = A Study on The Change of MDA, SOD, GPx, and CAT in Accordance with Exercise

다국어 초록 (Multilingual Abstract)

1. The change of MDA in accordance with exercise
Many researchers at home and abroad told that MDA concentration tends to be low significantly if
we do regular exercise in the long term. This means the adaptation of defence mechanism of
antioxidants caused by moderate exercise.
2. The change of SOD, GPx, and CAT in accordance with exercise.
The increase of SOD will be expected if a regular exercise in the long term is implemented
regardless of a type, intensity, and time of the exercise. Meanwhile, at preceding researches, CAT
showed significant change in high intensity exercise. It seems that GPx is significant when high intensity
exercise is done and it is more activated by long-term and long-time exercise.
3. An intake of antioxidants and the change of SOD, GPx, and CAT in accordance with exercise
It is reported that an intake and exercise of Vitamin C and E enhances resistiveness against lipid
peroxide, and endurance exercise capacity significantly in many researches. Also, an intake of
antioxidants and exercise do not have an effect on the activation of SOD through an intake of Vitamin,
but high intensity exercise and an intake of Vitamin enhance the activation of SOD, and CAT.
4. The change of immune system in accordance with exercise and an intake of antioxidants
It is reported that an intake of antioxidants and exercise have an effect on immune system. It is also
reported that the medium intensity exercise enhances the increase of immune system, but high intensity
exercise enhances the long-term increase of it. Meanwhile, if the period for an intake of antioxidants is
short, antioxidants do not affect immune system. Also, independent treatments of antioxidant vitamins is
limited about the improvement of immune function.
5. Suggestions
The excessive exercise increases antioxidant enzymes like SOD, CAT, and GPx in skeletal muscles,
heart, and livers. The threshold value and magnitude of exercise are different in accordance with
enzymes and tissues. The validity of these findings are recognized by studying the response of free
oxygen radicals in various tissues. However, mechanism that antioxidant enzymes are activated in short
term during exercise is not acknowledged so it may be necessary that a research should be
implemented about how the quick activation of antioxidant enzymes effectively responds to a cell
damage from peroxide lipid.
Also, the treatment of antioxidant vitamins enhances the activation of antioxidant enzymes and
immune function, but a research about proper intake and period of antioxidant vitamins in addition to
exercise in order to block the oxidative damage is necessary in the following research.
Meanwhile, Methionine is the essential amino acids for growth and maintenance of cellular tissues. Jo
Soo Yeal(1997) reported that an intake of Methionine improved the activation of SOD significantly.
It is also reported that sulfhydryl group, one of metabolites of Methionine, acts as a direct remover
of free radical, maintains Glutathione concentration constantly, and works as the disposition of
glutathione peroxidase to protect cells from lipid peroxidation.(Shwa, et al., 1981)
Methionine is the essential amino acids to protect cells from the reactive oxygen as a role of
antioxidants. Until now, comparative studies about Methionine and existing antioxidants in relation to
exercise have not been sufficient. Therefore, it may be meaningful that the effect on Methionine and
existing antioxidants in relation to the relation of exercise and antioxidant enzymes in the following
research.