Increase in Plasma Glucose Lowering Action of Rosiglitazone by Electroacupuncture at Bilateral Zusanli Acupoints (ST.36) in Rats

다국어 초록 (Multilingual Abstract)

Objectives: Hypoglycemia induced by electroacupuncture (EA) is due to an increase
of insulin secretion and/or mediation of β-endorphin. We applied EA at the Zusanli
(ST.36) acupuncture point (acupoint) in combination with rosiglitazone (TZD) administration
to evaluate their effect on plasma glucose and to explore possible mechanisms
of action.
Methods: Thirty six normal adult Wistar rats were randomly divided into four groups:
the 0.1 mg/kg TZD group (0.1TZD), 0.1 mg/kg TZD and EA group (0.1TZD + EA), EA
group, and control group. In other experiments, streptozotocin was used to induce
type 2 diabetes mellitus in neonatal rats; these were then randomly divided into a
0.1TZD group, 0.1TZD + EA group, and EA group and changes in plasma glucose and
insulin concentrations evaluated.
Results: A marked hypoglycemic response was observed in the normal rat 0.1TZD,
0.1TZD + EA and EA groups, with the response more significant in the 0.1TZD + EA group
than in the 0.1TZD group. Among the diabetic animals, the hypoglycemic responses
in the 0.1TZD + EA and EA groups were greater than in the 0.1TZD group. In both the
normal and diabetic rats, insulin secretion was increased by EA or 0.1TZD + EA treatment,
but not by 0.1TZD.
Conclusions: The plasma glucose lowering action of rosiglitazone was increased
by EA in both normal and diabetic rats, indicating that the application of EA may
enhance the hypoglycemic action of this insulin sensitizer.

다국어 초록 (Multilingual Abstract)

Objectives: Hypoglycemia induced by electroacupuncture (EA) is due to an increase
of insulin secretion and/or mediation of β-endorphin. We applied EA at the Zusanli
(ST.36) acupuncture point (acupoint) in combination with rosiglitazone (TZD) administration
to evaluate their effect on plasma glucose and to explore possible mechanisms
of action.
Methods: Thirty six normal adult Wistar rats were randomly divided into four groups:
the 0.1 mg/kg TZD group (0.1TZD), 0.1 mg/kg TZD and EA group (0.1TZD + EA), EA
group, and control group. In other experiments, streptozotocin was used to induce
type 2 diabetes mellitus in neonatal rats; these were then randomly divided into a
0.1TZD group, 0.1TZD + EA group, and EA group and changes in plasma glucose and
insulin concentrations evaluated.
Results: A marked hypoglycemic response was observed in the normal rat 0.1TZD,
0.1TZD + EA and EA groups, with the response more significant in the 0.1TZD + EA group
than in the 0.1TZD group. Among the diabetic animals, the hypoglycemic responses
in the 0.1TZD + EA and EA groups were greater than in the 0.1TZD group. In both the
normal and diabetic rats, insulin secretion was increased by EA or 0.1TZD + EA treatment,
but not by 0.1TZD.
Conclusions: The plasma glucose lowering action of rosiglitazone was increased
by EA in both normal and diabetic rats, indicating that the application of EA may
enhance the hypoglycemic action of this insulin sensitizer.

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