위암에 대한 형태계측학적 연구 = Morphometric Analysis of the gastric Cancer

다국어 초록 (Multilingual Abstract)

In gastric carcinomas including 20 cases of intestinal type and 20 cases of diffuse type, in adenoma (10 cases), and in metaplastic gastritis(10 cases), the presence of lactoferrin was investigated by immunohistochemistry. An evident reactivity for lactoferhn was encountered in intestinal type carcinomas, adenomas, and incomplete intestinal metaplasia.
The problems in identifyng the steps in the pathogenesis of gastric cancer and in the calssification of its preneoplastic lesions led to a throughout analysis of the morphologic features of metaplastic gastritis, adenoma and adenocarcinoma of the gastric mucosa. Recently, several morphologic features with possible diagnostic significance have been identified among these parameters, several cytologic features seem to be of major importance for the quantitative analysis of the stepwise develop merit of malignancy. We have chosen to study nuclear and cytoplasm measurements as seen in gastric biopsied specimens.
The results obtained were as follow:
1) Incomplete intestinal metaplasia, adenoma and intestinal type adenocarcinoma were stained with lactoferrin
2) Nuclear and cytoplasmic areas of incomplete metaplasia (50±14㎛_(2), 147±38㎛_(2)), Adenoma (56±16㎛_(2), 149±44㎛_(2)), Well differentiated adenocarcinoma(57±16㎛_(2), 152±48㎛_(2)), Moderate differentiated adenocarcinoma (44±14㎛_(2), 118±33㎛_(2)), Poor differentiated adenocarcinoma (54±16㎛_(2), 97±30㎛_(2)) and diffuse type adenocarcinoma (33±10㎛_(2) 434±124㎛_(2)) were noted.
3) Nuclear and cytoplasmic ratio of incomplete metaplasia(0.34±0.02), adenoma (0.38±0.02), well differentiated adenocarcinoma( 0.38±0.02), moderately differentiated adenocardnoma (0.37±0.02), Poor differentiated adenocarcinoma(0.56±0.01), and diffuse type adenocarcmoma (0.08±0.02) were noted.