This study aims to investigate the characteristic role of inhibitory receptor leukocyte‐associated immunoglobulin‐like receptor 1 (LAIR‐1) in oral squamous cell carcinoma (OSCC). The expressions of LAIR‐1 and other immune‐related molecules w...
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https://www.riss.kr/link?id=O119276398
Lei‐Lei Yang ; Meng‐Jie Zhang ; Lei Wu ; Liang Mao ; Lei Chen ; Guang‐Tao Yu ; Wei‐Wei Deng ; Wen‐Feng Zhang ; Bing Liu ; Wei‐Ke Sun ; Zhi‐Jun Sun
2019년
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1043-3074
SCI;SCIE;SCOPUS
학술저널
1080-1086 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
This study aims to investigate the characteristic role of inhibitory receptor leukocyte‐associated immunoglobulin‐like receptor 1 (LAIR‐1) in oral squamous cell carcinoma (OSCC). The expressions of LAIR‐1 and other immune‐related molecules w...
This study aims to investigate the characteristic role of inhibitory receptor leukocyte‐associated immunoglobulin‐like receptor 1 (LAIR‐1) in oral squamous cell carcinoma (OSCC).
The expressions of LAIR‐1 and other immune‐related molecules were detected in a human OSCC tissue microarray. LAIR‐1 expression difference among different clinicopathological parameters was analyzed. The correlations of LAIR‐1 with several immune‐related markers were assessed.
Compared with dysplasia and oral mucosa, the expression of LAIR‐1 was significantly upregulated in the stroma of OSCC, and its overexpression was correlated with advanced pathological grade. Overexpression of LAIR‐1 was significantly associated with tumor‐associated macrophage and myeloid‐derived suppressor cell markers (CD68, CD163; CD33, CD11b), indoleamine 2,3‐dioxygenase (IDO) and two immune checkpoints (B7‐H3 and VISTA).
Overexpression of LAIR‐1 was associated with advanced pathological grade and correlated with immune suppressive features in OSCC. Further studies are required to identify the specific immunological role of LAIR‐1.