리보플라빈이 함유된 키토산 마스크팩의 제조 및 특성에 관한 연구 = Studies on the Preparation of Chitosan Mask Pack Containing Riboflavin and There Characteristics

다국어 초록 (Multilingual Abstract)

This study was to investigate a preparation and characteristics of a peel-off type mask pack with chitosan, which is biocompatible biopolymer, as a model cosmetic delivery system. Chitosan microbeads having riboflavin for cosmetic delivery system have been obtained using capillary extrusion method. Intermolecular hydrogen bonding bands between ,chitosan molecule and riboflavin were observed at 3,429 cm-1 and 1,088 cm-1 in FT-IR spectrum. The band shifts may be assigned to a strong interaction due to intermolecular hydrogen bond between two molecules. The prototype formulation of peel-off type mask pack was also prepared by conventional method.The parameters to evaluate cosmetic effects consisted of skin hydration, pH, skin sebum, erythema index, TEWL, L*a*b* values. It was concluded that chitosan microbeads containing of riboflavin considered as a good candidate for the preparation of a functional peel-off type mask pack. The releasing property of riboflavin from chitosan microbeads is not clearly studied and requires further investigation.

참고문헌 (Reference)

1 Robbins CR, "Some observation on the swelling of human epidermal membrane" 34 : 21-34, 1983

2 Mitsui T, "New Cosmetic Science" Elservier 24-29, 1997

3 Muzzarelli RRA, "Natural Chelating Polymers" Pregamon Press 158-167, 1973

4 Prasad R, "Metabolim of H-proline in riboflavin deficiency" 30 (30): 300-307, 1996

5 Langer RS, "Medical Application of Controlled" CRC Press 258-269, 1994

6 Bendit EG, "Keratin in Encyclopedia of Polymer Science and Technology" John Wiley & Sons 260-268, 1968

7 Prasad R, "Impaired collagen maturity in vitamins B2 deficiency probable molecular basis of skin lesions" 30 (30): 333-341, 1983

8 Blank IH, "Further observations on factors which influence the water content of the stratum corneum" 21 : 259-269, 1953

9 Bukin IV, "Functional deficiency of riboflavin in patients with melanoma" 36 (36): 62-64, 1990

10 Blank IH, "Factors which influence the water content of the stratum corneum" 18 : 433-440, 1952

11 Levy G, "Enhanced intestinal absorption of riboflavin from sodium alginate solution in man" 61 : 279-280, 1972

12 Goosen MFA, "Applications of chitin and chitosan. Technomic Publishing" Lancaster 200-214, 1997

13 Chia CP, "Absorption of riboflavin in the isolated intestine of rats" 6 : 247-250, 1978