Antibacterial and Cytotoxic Activities of Schiff Base Analogues of 4-Aminoantipyrine

다국어 초록 (Multilingual Abstract)

Schiff base is the class of compounds showing widerange of biological activities having the azomethine (-N=CH-)active pharmacophore, which play major roles in their significantbio-activities. A series of Schiff base analogues of 4-aminoantipyrineanalogues have been tested for bactericidal andcytotoxic activities against selected bacterial strains and brineshrimp (Artemia salina) nauplii, respectively. Of the compoundstested, two compounds showed a good inhibition of bacterialgrowth against E. coli and C. sakazakii, whereas three compoundsdemonstrated high cytotoxicity with LC50 values of 225, 480, and581 ppm, in a short term bioassay using A. salina. Qualitativestructure-cytotoxic activity relationships were studied usingphysicochemical parameters; a good correlation between clogPand cytotoxic activity was observed.

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