Synthesis, antimicrobial evaluation and molecular modelling of novel sulfonamides carrying a biologically active quinazoline nucleus

다국어 초록 (Multilingual Abstract)

A novel series of quinazolines 5–10, triazoloquinazolines11–17 and triazinoquinazoline 19 bearing abiologically active sulfonamide moiety were synthesized,utilizing methyl 2-isothiocyanato benzoate 2. Some of thenewly synthesized compounds revealed promising bacterialgrowth inhibition, compared with the ampicillin, as thereference drug. A LigandScout approach-generated pharmacophoremodel for the Staph aureus bacteria growthinhibition was done. The degree of fitting of the test setcompounds (3, 4, 6, 8, 11, 17) to the generated hypotheticalmodel revealed a qualitative measure of the more orless microbial inhibition of Staphylococcus aureus. Compounds(7, 8, 10, 12, 15, 17 and 22), which revealed significantactivity, are able to effectively satisfy the proposedpharmacophore geometry, using the energy accessibleconformers (Econf\20 kcal/mol).

참고문헌 (Reference)

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