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      정신건강의학과 외래에서의 벤조디아제핀계 향정신성의약품 처방간격 관련요인 분석 = Factors Affecting the Prescription Interval of Benzodiazepines in Psychiatric Outpatient Treatment

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      https://www.riss.kr/link?id=A107379371

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      다국어 초록 (Multilingual Abstract)

      Objective : This study investigated the factors affecting the prescription interval of benzodiazepines and related psychotropics. Methods : The prescription intervals were extracted from all patients (n=1873) who visited the outpatient department ...

      Objective : This study investigated the factors affecting the prescription interval of benzodiazepines and related psychotropics. Methods : The prescription intervals were extracted from all patients (n=1873) who visited the outpatient department of a single psychiatric hospital for one month in June 2019, and the potential factors related to longer psychotropic prescription were explored. Logistic regression analysis was performed to assess the relationship between the potential risk factors and the length of psychotropic medication prescription in days. Results : Two cutoff values (30 days and 35 days) were used for the appropriate prescription interval. Older age [cutoff 30 days, Exp(B)= 1.014, p=0.001 ; cutoff 35 days, Exp(B)=1.014, p=0.001], fewer number of admissions [30 days, Exp(B)=0.459, p<0.001; 35 days, Exp(B)=0.438, p<0.001], fewer number of treatment sessions [30 days, Exp(B)=0.894, p<0.001; 35 days, Exp(B)=0.899, p<0.001], and longer duration of treatment [30 days, Exp(B)=1.022, p= 0.004 ; 35 days, Exp(B)=1.024, p=0.001] were related to a longer prescription interval of psychotropics. Longer duration of illness [30 days, Exp(B)=1.017, p=0.017] was related to a longer prescription term and on-site reception compared to reservation [35 days, Exp(B)=0.585, p=0.022] with a shorter prescription term. Conclusion : Our results suggest that the elderly and patients with a longer duration of illness need closer monitoring for long-interval prescription of benzodiazepines and related psychotropics.

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      목차 (Table of Contents)

      • 서론 방법 결과 고찰 결론
      • 서론 방법 결과 고찰 결론
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      참고문헌 (Reference)

      1 송진옥, "비정신과 의사의 벤조디아제핀 사용에 관한 예비 조사" 대한생물치료정신의학회 12 (12): 57-65, 2006

      2 임부돌, "고혈압 환자의 연간 내원일수,처방일수 그리고 진료비" 대한예방의학회 35 (35): 10-350, 2002

      3 Chang CM, "Utilization of psychopharmacological treatment among patients with newly diagnosed bipolar disorder from 2001 to 2010" 36 : 32-44, 2016

      4 Jang YJ, "Twelve-year trend in the use of zolpidem and physicians’ non-compliance with recommended duration : a Korean national health insurance database study" 75 : 109-117, 2019

      5 Bjørklund L, "Trends in the psychopharmacological treatment of bipolar disorder : a nationwide register-based study" 28 : 75-84, 2016

      6 Ashton H, "Toxicity and adverse consequences of benzodiazepine use" 25 : 158-165, 1995

      7 Fenton MC, "The role of a prescription in anxiety medication use, abuse, and dependence" 167 : 1247-1253, 2010

      8 Crowe SF, "The residual medium and long-term cognitive effects of benzodiazepine use : an updated meta-analysis" 33 : 901-911, 2018

      9 Lage MJ, "The relationship between antipsychotic medication adherence and patient outcomes among individuals diagnosed with bipolar disorder : a retrospective study" 8 : 7-, 2009

      10 Blanco C, "The latent structure and predictors of non-medical prescription drug use and prescription drug use disorders : a national study" 133 : 473-479, 2013

      1 송진옥, "비정신과 의사의 벤조디아제핀 사용에 관한 예비 조사" 대한생물치료정신의학회 12 (12): 57-65, 2006

      2 임부돌, "고혈압 환자의 연간 내원일수,처방일수 그리고 진료비" 대한예방의학회 35 (35): 10-350, 2002

      3 Chang CM, "Utilization of psychopharmacological treatment among patients with newly diagnosed bipolar disorder from 2001 to 2010" 36 : 32-44, 2016

      4 Jang YJ, "Twelve-year trend in the use of zolpidem and physicians’ non-compliance with recommended duration : a Korean national health insurance database study" 75 : 109-117, 2019

      5 Bjørklund L, "Trends in the psychopharmacological treatment of bipolar disorder : a nationwide register-based study" 28 : 75-84, 2016

      6 Ashton H, "Toxicity and adverse consequences of benzodiazepine use" 25 : 158-165, 1995

      7 Fenton MC, "The role of a prescription in anxiety medication use, abuse, and dependence" 167 : 1247-1253, 2010

      8 Crowe SF, "The residual medium and long-term cognitive effects of benzodiazepine use : an updated meta-analysis" 33 : 901-911, 2018

      9 Lage MJ, "The relationship between antipsychotic medication adherence and patient outcomes among individuals diagnosed with bipolar disorder : a retrospective study" 8 : 7-, 2009

      10 Blanco C, "The latent structure and predictors of non-medical prescription drug use and prescription drug use disorders : a national study" 133 : 473-479, 2013

      11 Neutel CI, "The epidemiology of long-term benzodiazepine use" 17 : 189-197, 2005

      12 Fride TI, "Risk factors for excessive benzodiazepine use in a working age population : a nationwide 5-year survey in Norway" 33 : 252-259, 2015

      13 Simoni WL, "Risk factors associated with problem use of prescription drugs" 94 : 266-268, 2004

      14 Joelle MH, "Reimbursement restriction and moderate decrease in benzodiazepine use in general practice" 10 : 42-49, 2012

      15 Movig KL, "Psychoactive substance use and the risk of motor vehicle accidents" 36 : 631-636, 2004

      16 Blanco C, "Prevalence and correlates of benzodiazepine use, misuse, and use disorders among adults in the United States" 79 : 2018

      17 Kim S, "Prescription pattern of antidepressants among the korean patients with depression" Seoul National University College of Medicine 2018

      18 Fang SY, "Predictors of the incidence and discontinuation of long-term use of benzodiazepines : a population-based study" 104 : 140-146, 2009

      19 Laurito LD, "Predictors of benzodiazepine use in a transdiagnostic sample of panic disorder, social anxiety disorder, and obsessive-compulsive disorder patients" 262 : 237-245, 2018

      20 Agarwal SD, "Patterns in outpatient benzodiazepine prescribing in the United States" 2 : e187399-e187399, 2019

      21 College of family physicians Singapore, "MOH clinical practice guidelines 2/2008:prescribing of benzodiazepines" Ministry of Health 2008

      22 Fulone I, "Long-term benzodiazepine use in patients taking antidepressants in a public health setting in Brazil : a cross-sectional study" 8 : 2018

      23 Wingård L, "Initiation and long-term use of benzodiazepines and Zdrugs in bipolar disorder" 20 : 634-646, 2018

      24 Bradley F, "Influence of prescription charges on repeat prescribing in primary care" 32 : 269-275, 2007

      25 Bachhuber MA, "Increasing benzodiazepine prescriptions and overdose mortality in the United States, 1996-2013" 106 : 686-688, 2016

      26 Jasuja GK, "Gender differences in prescribing of zolpidem in the Veterans Health Administration" 25 : e58-e65, 2019

      27 Bernardy NC, "Gender differences in prescribing among veterans diagnosed with posttraumatic stress disorder" 28 : 542-548, 2013

      28 Marti J, "Financial incentives to discontinue long-term benzodiazepine use : a discrete choice experiment investigating patient preferences and willingness to participate" 7 : e016229-, 2017

      29 Voyer P, "Factors associated with psychotropic drug use among community-dwelling older persons : a review of empirical studies" 3 : 3-, 2004

      30 Steinman MA, "Epidemic use of benzodiazepines among older adults in Israel : epidemiology and leverage points for improvement" 32 : 891-899, 2017

      31 Colin RD, "Effect of a centralized prescription network on inappropriate prescriptions for opioid analgesics and benzodiazepines" 184 : E852-E856, 2012

      32 Service HIRA, "Details on the standards and methods of applying for medical care benefits (pharmaceutical)"

      33 Takeshima N, "Continuation and discontinuation of benzodiazepine prescriptions : a cohort study based on a large claims database in Japan" 237 : 201-207, 2016

      34 Demyttenaere K, "Clinical factors influencing the prescription of antidepressants and benzodiazepines : results from the European study of the epidemiology of mental disorders(ESEMeD)" 110 : 84-93, 2008

      35 Neutel CI, "Can continuing benzodiazepine use be predicted?" 10 : 202-206, 2003

      36 Haw C, "Benzodiazepines-a necessary evil? A survey of prescribing at a specialist UK psychiatric hospital" 21 : 645-649, 2007

      37 Wolkowitz OM, "Benzodiazepines in the treatment of schizophrenia. A Review and Re-appraisal" 148 : 714-726, 1991

      38 Ettcheto M, "Benzodiazepines and related drugs as a risk factor in Alzheimer’s disease dementia" 11 : 2019

      39 Olfson M, "Benzodiazepine use in the United States" 72 : 136-142, 2015

      40 Perlis RH, "Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report" 2010

      41 Kim YJ, "Benzodiazepine prescription patterns for the elderly patients at ambulatory care in korea" 1 : 59-66, 2008

      42 Johnson E, "Antipsychotic treatment patterns and hospitalizations among adults with schizophrenia" 101 : 304-311, 2008

      43 Furukawa TA, "Antidepressants plus benzodiazepines for major depression" 2001

      44 Schorr SG, "A cross-sectional study of prescribing patterns in chronic psychiatric patients living in sheltered housing facilities" 46 : 146-, 2008

      45 Service HIRA, "2018 prescribing status of insurance payment drug"

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