크롬 노출 근로자의 말초혈액 임파구내 소핵출현에 관한 연구 = Micronuclei in Peripheral Blood Lymphocytes of Chromate Workers

다국어 초록 (Multilingual Abstract)

Objectives: The goal of this study is to observe the associations between the chrome concentrations (blood and urine) and number of lymphocyte with micronuclei among workers exposed to chrome. Additionally to test appropriateness of micronuclei test for biologic monitoring markers such as urine or blood chrome.
Methods: Twenty-seven pairs of subjects exposed to chromate environment and non-exposed were matched with age and smoking habit, and all subjects were composed of male workers only.
Results: In control group, age-related increment in number of cultured lymphocytes with micronuclei was observed statistically significant. But, in exposed group, similar results were revealed without statistically significance. Number of lymphocytes with micronuclei was significantly increased with the increment of blood or urinary Cr concentration. The number of lymphocytes with micronuclei were highly correlated with age and smoking habit in control group. But, in chromate exposed group, age and logarithmic converted concentration of urinary Cr were significantly correlated with appearance of micronuclei. In both of control and exposed group, age, urinary concentration of Cr and logarithmic converted concentration of blood Cr were thought to be important variables.
Conclusions: There was close relationship between the micronuclei assay for evaluation of mutagenesis and biological exposure markers such as blood or urinary Cr concentration of chromate workers. And obtained results suggested that further studies for establishing age-related reference frequencies of the micronuclei appearance for general people of Korean were needed to clarify physical increment with aging.