Eighty chemicals including pesticides synthetic estrogens, raw materials used in industry were applied to E-Screen assay in this study. MCF-7 cell, used in E-Screen assay, is known to be proliferated by addition of estrogens and have been widely used ...
Eighty chemicals including pesticides synthetic estrogens, raw materials used in industry were applied to E-Screen assay in this study. MCF-7 cell, used in E-Screen assay, is known to be proliferated by addition of estrogens and have been widely used to defect estrogen-like chemicals. Nine of 80 chemicals showed proliferative activity in a dose-dependent manner. Six of these 9 chemicals were hsted as EDCs in Strategic Programs on Environmental Endocrine Disruptors by Environmental Agency. Government of Japan Four chemicals were recognized to have proliferative activities in this study.