Background/Aims Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients. Methods We c...
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https://www.riss.kr/link?id=A106414936
Sumire Mori (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan) ; Toshihiko Tomita (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan) ; Kazuki Fujimura (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan) ; Haruki Asano (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan) ; Tomohiro Ogawa (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan) ; Takahisa Yamasaki (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan) ; Takashi Kondo (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan) ; Tomoaki Kono (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan) ; Katsuyuki Tozawa (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan) ; Tadayuki Oshima (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan) ; Hirokazu Fukui (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan) ; Takeshi Kimura (Department of Pharmacy, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan) ; Jiro Watari (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan) ; Hiroto Miwa (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan)
2019
English
KCI등재,SCIE,SCOPUS
학술저널
563-575(13쪽)
1
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Background/Aims Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients. Methods We c...
Background/Aims
Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients.
Methods
We conducted a randomized, double-blind placebo-controlled study. Thirty-four female patients with mild to moderate constipation were randomly assigned to either placebo (n = 17) or MgO group (n = 17) 0.5 g × 3/day for 28 days. Primary endpoint was overall improvement over the 4-week study period. Secondary endpoints were changes from baseline in spontaneous bowel movement (SBM), response rates of complete spontaneous bowel movement (CSBM), stool form, colonic transit time (CTT), abdominal symptom, and quality of life.
Results
One patient failed to complete the medication regimen and was omitted from analysis: data from 16 placebo and 17 MgO patients were analyzed. The primary endpoint was met by 25.0% of placebo vs 70.6% of MgO group (P = 0.015). MgO significantly improved SBM changes compared to placebo (P = 0.002). However, MgO did not significantly improved response rates of CSBM compared to placebo (P = 0.76). In addition, MgO significantly improved Bristol stool form scale changes (P < 0.001) and significantly improved CTT compared to the placebo group (P < 0.001). MgO significantly improved the Japanese version of the patient assessment of constipation quality of life (P = 0.003).
Conclusion
Our placebo-controlled study demonstrated that MgO was effective treatment for improving defecation status and shortened CTT in Japanese CC patients with mild to moderate symptoms.
다국어 초록 (Multilingual Abstract)
Background/Aims Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients. Methods We conducted ...
Background/Aims
Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients.
Methods
We conducted a randomized, double-blind placebo-controlled study. Thirty-four female patients with mild to moderate constipation were randomly assigned to either placebo (n = 17) or MgO group (n = 17) 0.5 g × 3/day for 28 days. Primary endpoint was overall improvement over the 4-week study period. Secondary endpoints were changes from baseline in spontaneous bowel movement (SBM), response rates of complete spontaneous bowel movement (CSBM), stool form, colonic transit time (CTT), abdominal symptom, and quality of life.
Results
One patient failed to complete the medication regimen and was omitted from analysis: data from 16 placebo and 17 MgO patients were analyzed. The primary endpoint was met by 25.0% of placebo vs 70.6% of MgO group (P = 0.015). MgO significantly improved SBM changes compared to placebo (P = 0.002). However, MgO did not significantly improved response rates of CSBM compared to placebo (P = 0.76). In addition, MgO significantly improved Bristol stool form scale changes (P < 0.001) and significantly improved CTT compared to the placebo group (P < 0.001). MgO significantly improved the Japanese version of the patient assessment of constipation quality of life (P = 0.003).
Conclusion
Our placebo-controlled study demonstrated that MgO was effective treatment for improving defecation status and shortened CTT in Japanese CC patients with mild to moderate symptoms.
참고문헌 (Reference)
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3 Turner-Bowker DM, "Usefulness of the SF-8 health survey for comparing the impact of migraine and other conditions" 12 : 1003-1012, 2003
4 Lembo AJ, "Two randomized trials of linaclotide for chronic constipation" 365 : 527-536, 2011
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6 Tsunoda A, "The translation and validation of the Japanese version of the patient assessment of constipation quality of life scale" 46 : 414-421, 2016
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Prevalence and Severity of Fecal Incontinence in Veterans
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
2010-05-11 | 학술지명변경 | 한글명 : 대한소화관 운동학회지 -> Journal of Neurogastroenterology and Motility (JNM)외국어명 : Korean Journal of Neurogastroenterology and Motility -> Journal of Neurogastroenterology and Motility (JNM) | |
2010-05-10 | 학회명변경 | 한글명 : 대한소화관운동학회 -> 대한소화기 기능성질환∙운동학회 | |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2006-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2005-05-24 | 학회명변경 | 영문명 : The Korean Society Of Gastrointestinal Motility -> The Korean Society of Neurogastroenterology and Motility | |
2004-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 2.36 | 0.65 | 1.69 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
1.19 | 1.03 | 0.459 | 0.23 |