<P>Roots of <I>Asparagus cochinchinesis</I> have been widely used to treat fever, cough, kidney disease, breast cancer, inflammatory and brain disease, although the effects of their fermented products have not been assessed until now...
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=A107661339
2017
-
SCIE
학술저널
4986-4994(9쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Roots of <I>Asparagus cochinchinesis</I> have been widely used to treat fever, cough, kidney disease, breast cancer, inflammatory and brain disease, although the effects of their fermented products have not been assessed until now...
<P>Roots of <I>Asparagus cochinchinesis</I> have been widely used to treat fever, cough, kidney disease, breast cancer, inflammatory and brain disease, although the effects of their fermented products have not been assessed until now. To investigate the anti-inflammatory effects on macrophages of a butanol extract from <I>A. cochinchinensis</I> roots fermented with <I>Weissella cibaria</I> (BAW), alterations in the inducible nitric oxide synthase (iNOS)-mediated cyclooxygenase-2 (COX-2) induction pathway and inflammatory cytokine expression were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells following pretreatment with BAW. Briefly, <I>W. cibaria</I> was selected from two bacterial strains for the fermentation of <I>A. cochinchinensis</I> roots based on its hyaluronidase inhibition and NO suppression rates. Following fermentation with <I>W. cibaria</I>, the level of various key components including total phenols and protodioscin were significantly enhanced in BAW. In addition, BAW exhibited high free radical scavenging activity (IC<SUB>50</SUB>=31.62 µg/ml) and induced a decrease of intracellular ROS production in RAW264.7 cells following DCFH-DA staining. Significant suppressions in the expression level of important members of the iNOS-mediated COX-2 induction pathway and the phosphorylation of mitogen-activated protein kinase members were detected. The expressions of pro-inflammatory and anti-inflammatory cytokines were recovered in BAW pretreated RAW264.7 cells. Overall, these results suggest that BAW may suppress inflammatory responses through differential regulation of the iNOS-mediated COX-2 induction pathway and inflammatory cytokine expressions in LPS-activated RAW264.7 cells.</P>