중풍환자에서 수족냉증과 적혈구변형능의 관련성 연구 = The Relationship between Coldness of Hands and Feet and the Erythrocyte Deformability in Stroke Patients

다국어 초록 (Multilingual Abstract)

Objectives : Coldness of hands and feet has been regarded to be associated with blood circulation. This study was performed to assess the correlation between erythrocyte deformability and coldness of hands and feet. Methods : 145 patients who had taken an erythrocyte deformability test were selected for this study among hospitalized patients within 4 weeks after their cerebral infarction at the Internal Medical Department at Kyunghee Oriental Medical Center from August 2008 to August 2009. We divided the selected patients into two groups, with and without of coldness of hands and feet groups. The two groups were compared on risk factors for atherosclerosis and examined for variables including erythrocyte deformability. Results : 1. On demographic variables of the patients, only body mass index was significantly lower in the coldness of hands and feet group than the control group. There was no significant difference of the rate of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, smoking, drinking and carotid artery stenosis between the two groups. 2. According to blood test, the coldness of hands and feet group showed significantly lower erythrocyte deformability index than the control group. 3. Body mass index and erythrocyte deformability index showed a close relationship with coldness of hands and feet in multivariate analysis. Conclusions : The correlation between the erythrocyte deformability and coldness of hands and feet in cerebral infarction patients were decreased erythrocyte deformability participated in the mechanism of coldness of hands and feet.

참고문헌 (Reference)

1 최환석, "수족부 감각이상자에서 레이노병의 유병률" 24 (24): 1085-1091, 2003

2 김철민, "수족냉증과 레이노병에 대한 일부 가정의의 인식도" 대한가정의학회 28 (28): 339-345, 2007

3 문준전, "상한론정해" 경희대학교 출판국 568-, 1996

4 이상엽, "레이노 현항; 가정의학 임상편" 계축문화사 628-633, 2002

5 S. Shin, "Validation and application of a microfluidic ektacytometer (RheoScan-D) in measuring erythrocyte Deformability" 37 : 319-328, 2007

6 Seh-yun Shin, "Rheological characteristics of erythrocytes incubated in glucose media" 38 : 153-161, 2008

7 American Diabetes Association, "Report of the expert committee on the Diagnosis and classification of Diabetes Mellitus" 20 : 1183-1197, 1997

8 Steven S.Segal, "Regulation of Blood Flow in the Microcirculation" 12 (12): 33-45, 2005

9 Seh-yun Shin, "Progresive impairment of erythrocyte deformability as indicator of microangiography in type 2 diabetes melitus" 36 : 253-256, 2007

10 Maricq HR, "Prevalence of scleroderma spectrum disorders in the general population of South Carolina" 32 : 998-1006, 1989

11 A.L.Herrick, "Pathogenesis of Raynaud's phenomenon" 44 : 587-596, 2005

12 H.H.Lipowsky, "Microvascular rheology and hemodynamics" 12 (12): 5-15, 2005

13 S.Simchon, "Influence of Reduced Red-Cell Deformability on Regional Blood-Flow" 253 : H898-H903, 1987

14 L.Dintenfass, "Hyperviscosity and Hyperviscosemia" MTP Press 1985

15 O.K.Baskurt, "Handbook of Hemorheology and Hemodynamics" ISO Press 34-71, 2007

16 Executive Summary of the Third Report of the National Cholesterol Education Program (NECP), "Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel Ⅲ)" 285 : 2486-2497, 2001

17 김동현, "Ektacytometer를 이용한 tert-Butyl Hydroperoxide, Verapamil 및 Ascorbate 처리 적혈구의 혈액유변학적 변형능 측정" 대한진단검사의학회 28 (28): 325-331, 2008

18 Qiao Yang, "Effects of Toki-shakuyaku-san on microcirculation of bulbar conjunctiva and hemorheological factor in patients with asymptomatic cerebral infarction" 21 : 170-173, 2004

19 Seventh Report of the Joint National Committee on the Prevention, "Detection, Evaluation, and Treatment of High Blood Pressure"

20 The societyof Modern Health Research, "Comprehensive Cold Hypersensitivity Treatment Method" Jinhwadang 7-, 1994