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Yang, Eun Joo,Shin, Eun-Kyoung,Shin, Hyung-Ik,Lim, Jae-Young Springer International ; Springer 2014 Supportive Care in Cancer Vol.22 No.10
<P>The purpose of this study was to construct a clinical instrument to measure functioning in breast cancer survivors using the International Classification of Functioning, Disability and Health (ICF) categories for body functions, activity and participation, and environmental factors, based on a Rasch analysis.</P>
Cho, K.R.,Choi, J.S.,Hahn, W.,Kim, D.S.,Park, J.S.,Lee, D.S.,Kim, K.B. Springer International ; Springer-Verlag New York 2008 European journal of cardio-thoracic surgery Vol.34 No.4
Objective: We evaluated the potency of therapeutic angiogenesis using intramyocardial injection of naked DNA expressing two isoforms of hepatocyte growth factor (pCK-HGF-X7) in a porcine myocardial infarction model. Methods: Four weeks after left anterior descending coronary artery ligation, 14 pigs were allocated to pCK-Null (negative control, n=7) or pCK-HGF-X7 (n=7) treatment groups. Gated myocardial single photon emission computed tomography was performed 4 and 8 weeks following coronary ligation. The effect of pCK-HGF-X7 on capillary density in the gene-injected myocardium was examined by histological analysis using alkaline phosphatase staining. Results: Segmental myocardial perfusion of the underperfused area (@?70%) from coronary ligation increased in the pCK-HGF-X7 group (p=0.051), without significant differences in changes over time between the two groups (p=0.54). Systolic wall thickening (p=0.001), left ventricular end-diastolic (p=0.045) and end-systolic volumes (p=0.009), and left ventricular ejection fraction (p=0.041) changed in both groups without significant differences in changes over time between the two groups. The increase in the left stoke volume was higher in the pCK-HGF-X7 group than in the pCK-Null group (p=0.008). Histological analysis showed that capillary density was significantly higher in the pCK-HGF-X7 group than the pCK-Null group (p<0.001). Conclusion: Intramyocardial injection of pCK-HGF-X7 induced significant angiogenesis at infarct-border zone, and increased the left ventricular stroke volume probably caused by reverse remodeling process.
Oh, Heung-Kwon,Lee, Hye Seung,Lee, Jin Ho,Oh, Se Heang,Lim, Jae-Young,Ahn, Soyeon,Kang, Sung-Bum Springer International ; Springer-Verlag, distribu 2015 International journal of colorectal disease Vol.30 No.4
<P>Basic fibroblastic growth factor (bFGF), a member of the heparin-binding growth factor family, regulates muscle differentiation. We investigated whether coadministration of autologous myoblasts and bFGF-loaded polycaprolactone beads could improve sphincter recovery in a dog model of fecal incontinence (FI). FI was induced by resecting 25 % of the posterior anal sphincter in ten mongrel dogs. One month later, the dogs were randomized to receive either PKH-26-labeled autologous myoblasts alone (M group, five dogs) or autologous myoblasts and bFGF-loaded polycaprolactone beads (MBG group, five dogs). The outcomes included anal manometry, compound muscle action potentials (CMAPs) of the pudendal nerve, and histology. The increase in anal contractile pressure over 3 months was significantly greater in the MBG group (from 4.85 to 6.83 mmHg) than that in the M group (from 4.94 to 4.25 mmHg), with a coefficient for the difference in recovery rate of 2.672 (95 % confidence interval [CI] 0.962 to 4.373, p = 0.002). The change in the CMAP amplitude was also significantly greater in the MBG group (from 0.59 to 1.56 mV) than that in the M group (from 0.81 to 0.67 mV) (coefficient 1.114, 95 % CI 0.43 to 1.80, p = 0.001). Labeled cells were detected in 2/5 (40 %) and 5/5 (100 %) dogs in the M and MBG groups, respectively. Coadministration of bFGF-loaded PCL beads and autologous myoblasts improved the recovery of sphincter function in a dog model of FI and had better outcomes than cell-based therapy alone.</P>
Pack, Seung-Chul,Kim, Hye-Ran,Lim, Sang-Woo,Kim, Hwan-Young,Ko, Jung-Yun,Lee, Ki-Sang,Hwang, David,Park, Seong-Il,Kang, Hoon,Park, Sang-Wook,Hong, Gun-Young,Hwang, Se-Min,Shin, Myung-Geun,Lee, Soong Springer International ; Springer-Verlag, distribu 2013 International journal of colorectal disease Vol.28 No.1
<P>The purpose of present study was to investigate the methylation status of the promoter region in five genes (mothers against decapentaplegic homolog 4, fragile histidine triad protein, death-associated protein kinase 1, adenomatous polyposis coli (APC), and E-cadherin), which are known to be involved in the pathogenesis of colorectal cancer (CRC) and its clinicopathological significance.</P>
Choi, Yoo A,Yoo, Sang Hoon,Song, Youn Mi,Kim, Se Young,Nam, Yunju,Choi, Sooa,Kong, Bong Han,Yoon, Hye Eun,Hong, Yu Ah,Chang, Yoon Kyung,Yang, Chul Woo,Kim, Suk Young,Hwang, Hyeon Seok Springer International ; Springer-Verlag, distribu 2015 International journal of colorectal disease Vol.30 No.7
<P>The immunochemical fecal occult blood test (iFOBT) is a useful method to screen for lower gastrointestinal (GI) bleeding-related lesions. However, few studies have investigated the diagnostic utility of iFOBT in chronic kidney disease (CKD).</P>
Lee, Seunghoon,Jerng, Ui Min,Liu, Yan,Kang, Jung Won,Nam, Dongwoo,Lee, Jae-dong Springer International ; Springer 2014 Supportive care in cancer Vol.22 No.5
<P>Among cancer patients, cancer-related fatigue (CRF) is one of the most common symptoms and adversely affects physical ability and quality of life even several years after treatment. This study aims to evaluate the current evidence for moxibustion in patients with CRF.</P>
Jung, Hee-Won,Kim, Jin Won,Kim, Ji-Yeon,Kim, Sun-Wook,Yang, Hyun Kyung,Lee, Joon Woo,Lee, Keun-Wook,Kim, Duck-Woo,Kang, Sung-Bum,Kim, Kwang-Il,Kim, Cheol-Ho,Kim, Jee Hyun Springer International ; Springer 2015 SUPPORTIVE CARE IN CANCER Vol.23 No.3
<P>The purpose of this study was to elucidate the effect of decreased muscle mass on the toxicity and survival of patients with colon cancer treated with adjuvant chemotherapy after surgery.</P>
Results of an extracardiac pericardial-flap lateral tunnel Fontan operation
Park, H.K.,Youn, Y.N.,Yang, H.S.,Yoo, B.W.,Choi, J.Y.,Park, Y.H. Springer International ; Springer-Verlag New York 2008 European journal of cardio-thoracic surgery Vol.34 No.3
Objective: Extracardiac pericardial-flap lateral tunnel Fontan operation has the theoretical advantage of growth potentiality of the extracardiac tunnels. The mid-term results of this technique and morphologic change of the lateral tunnel were studied. Methods: Clinical data were reviewed in 42 patients who underwent extracardiac pericardial-flap lateral tunnel Fontan operation between November 1993 and December 2004. The age was 2.8+/-1.5 years and the body weight was 12.3+/-3.2kg. Extracardiac tunnel was constructed using the pedicled pericardium with the base undetached. By reviewing the follow-up cardiac angiograms (2.3+/-1.4 years postoperatively), ratios of diameter and cross-sectional area of the lateral tunnel to those of inferior vena cava were obtained. Results: There were 4 surgical mortalities (10%). Postoperative morbidity included prolonged pleural effusion in 5 patients and heart block in 1 patient. Follow-up was possible in 37 patients and the follow up duration was 3.8+/-2.2 years. There were two late deaths due to ventricular dysfunction and sudden death of unknown causes. Two patients required reoperation due to subaortic stenosis and stenosis between inferior vena cava and lateral tunnel. In one patient, bradyarrhythmia was observed but there was no thromboembolic complication. Follow-up anteroposterior and lateral diameter ratio were 1.1+/-0.5 and 1.2+/-0.5. The cross-sectional area ratio was 2.6+/-2.3. In 5 patients, fusiform dilatation of the lateral tunnel was observed, but in the remaining patients, the lateral tunnel preserved tubular morphology with good hemodynamics. Conclusions: Extracardiac pericardial-flap lateral tunnel Fontan operation is relatively simple and feasible even in patients with previous median sternotomies. The mid-term results were acceptable, and the lateral tunnel demonstrated a tendency to preserve its tubular shape. However in some patients, dilatation of the pericardial-flap tunnel was observed during follow up. Longer follow-up is required to determine the morphologic changes of the lateral tunnel and the value of this technique.
Hwang, In-Chang,Kim, Yong-Jin,Kim, Kyung-Hee,Lee, Seung-Pyo,Kim, Hyung-Kwan,Sohn, Dae-Won,Oh, Byung-Hee,Park, Young-Bae Springer International ; Springer-Verlag New York 2013 European journal of cardio-thoracic surgery Vol.43 No.1
<P>The prognostic value of B-type natriuretic peptide (BNP) for surgical outcome in patients with mitral regurgitation (MR) has not been studied. The purpose of this study was to determine the prognostic value of BNP in patients with chronic severe MR, undergoing mitral valve surgery.</P>