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Yang, Eun Joo,Shin, Eun-Kyoung,Shin, Hyung-Ik,Lim, Jae-Young Springer International ; Springer 2014 Supportive Care in Cancer Vol.22 No.10
<P>The purpose of this study was to construct a clinical instrument to measure functioning in breast cancer survivors using the International Classification of Functioning, Disability and Health (ICF) categories for body functions, activity and participation, and environmental factors, based on a Rasch analysis.</P>
Lee, Jong Hoon,Kim, Sung Hwan,Jang, Hong Seok,Chung, Hyuk Jun,Oh, Seong Taek,Lee, Doo Seok,Kim, Jun-Gi Springer International ; Springer-Verlag, distribu 2013 International journal of colorectal disease Vol.28 No.4
<P>This study was conducted to evaluate the significance of carcinoembryonic antigen (CEA) level as a predictor for tumor response to chemoradiotherapy (CRT) and a prognosticator for survival in Asian patients with advanced rectal cancer.</P>
Kim, Jin C,Yu, Chang S,Lim, Seok-B,Kim, Chan W,Park, In J,Yoon, Yong S Springer International ; Springer-Verlag, distribu 2015 International journal of colorectal disease Vol.30 No.10
<P>We evaluated the current practice of ultra-low anterior resection (uLAR) in patients with lower rectal cancer and compared uLARs using mostly transabdominal approach with or without intersphincteric resection (ISR).</P>
Segmental hair analysis and estimation of methamphetamine use pattern.
Han, Eunyoung,Yang, Heejin,Seol, Ilung,Park, Yunshin,Lee, Bongwoo,Song, Joon Myong Springer International ; Springer 2013 International journal of legal medicine Vol.127 No.2
<P>The aim of this study was to investigate whether the results of segmental hair analysis can be used to estimate patterns of methamphetamine (MA) use. Segmental hair analysis for MA and amphetamine (AP) was performed. Hair was cut into the hair root, consecutive 1?cm length segments and 1-4?cm length segments. Whole hair was also analyzed. The hair samples were incubated for 20?h in 1?mL methanol containing 1?% hydrochloric acid after washing the hair samples. Hair extracts were evaporated and derivatization was performed using trifluoroacetic anhydride in ethylacetate at 65?C for 30?min. Derivatized extract was analyzed by gas chromatography/mass spectrometry. The 15 subjects consisted of 13 males and two females and their ages ranged from 25 to 42 (mean, 32). MA and AP concentrations in the whole hair ranged from 3.00 to 105.10?ng/mg (mean, 34.53) and from 0.05 to 4.76?ng/mg (mean, 2.42), respectively. Based on the analysis of the 1?cm length segmental hair, the results were interpreted in a way to distinguish between continuous use of MA (n?=?10), no recent but previous use of MA (n?=?3), and recent but no previous use of MA (n?=?2). Furthermore, the individuals were interpreted as light, moderate, and heavy users based on concentration ranges previously published.</P>
Kim, Kyung-Yong,Kwon, Younghyuk,Bazarragchaa, Munkhtsetseg,Park, Ae-Ja,Bang, Hyowon,Lee, Won-Bok,Lee, Junyoung,Lee, Kwang-Ho,Kim, Bum-Joon,Kim, Kijeong Springer International ; Springer 2013 International journal of legal medicine Vol.127 No.1
<P>Allelic dropout due to stochastic variation in degraded small quantity DNA appears to be one of the most serious genotyping errors. Most methods require PCR replication to address this problem. The small amounts of valuable samples are often a limitation for such replications. We report a real-time PCR-based amelogonin Y (AMELY) allele dropout estimation model in an AMEL-based gender typing. We examined 915 replicates of AMELY-positive modern male DNA with varying amounts of DNA and humic acid. A male-specific AMEL fragment (AMELy) dropped out in 143 genuine male replicates, leading to gender typing errors. By graphing a scatter plot of the crossing point versus the end cycle fluorescence of the male replicates, a standard graph model for the estimation of the AMELy allele dropout was constructed with the dropout-prone and dropout-free zones. This model was then applied to ancient DNA (aDNA) samples. Nine samples identified as female were found in the dropout-prone zone; with higher DNA concentrations, six were shifted to the dropout-free zone. Among them, two female identifications were converted to male. All the aDNA gender was confirmed by sex-determination region Y marker amplification. Our data suggest that this model could be a basic approach for securing AMELy allele dropout-safe data from the stochastic variation of degraded inhibitory DNA samples.</P>
Pack, Seung-Chul,Kim, Hye-Ran,Lim, Sang-Woo,Kim, Hwan-Young,Ko, Jung-Yun,Lee, Ki-Sang,Hwang, David,Park, Seong-Il,Kang, Hoon,Park, Sang-Wook,Hong, Gun-Young,Hwang, Se-Min,Shin, Myung-Geun,Lee, Soong Springer International ; Springer-Verlag, distribu 2013 International journal of colorectal disease Vol.28 No.1
<P>The purpose of present study was to investigate the methylation status of the promoter region in five genes (mothers against decapentaplegic homolog 4, fragile histidine triad protein, death-associated protein kinase 1, adenomatous polyposis coli (APC), and E-cadherin), which are known to be involved in the pathogenesis of colorectal cancer (CRC) and its clinicopathological significance.</P>
Oh, Heung-Kwon,Lee, Hye Seung,Lee, Jin Ho,Oh, Se Heang,Lim, Jae-Young,Ahn, Soyeon,Kang, Sung-Bum Springer International ; Springer-Verlag, distribu 2015 International journal of colorectal disease Vol.30 No.4
<P>Basic fibroblastic growth factor (bFGF), a member of the heparin-binding growth factor family, regulates muscle differentiation. We investigated whether coadministration of autologous myoblasts and bFGF-loaded polycaprolactone beads could improve sphincter recovery in a dog model of fecal incontinence (FI). FI was induced by resecting 25 % of the posterior anal sphincter in ten mongrel dogs. One month later, the dogs were randomized to receive either PKH-26-labeled autologous myoblasts alone (M group, five dogs) or autologous myoblasts and bFGF-loaded polycaprolactone beads (MBG group, five dogs). The outcomes included anal manometry, compound muscle action potentials (CMAPs) of the pudendal nerve, and histology. The increase in anal contractile pressure over 3 months was significantly greater in the MBG group (from 4.85 to 6.83 mmHg) than that in the M group (from 4.94 to 4.25 mmHg), with a coefficient for the difference in recovery rate of 2.672 (95 % confidence interval [CI] 0.962 to 4.373, p = 0.002). The change in the CMAP amplitude was also significantly greater in the MBG group (from 0.59 to 1.56 mV) than that in the M group (from 0.81 to 0.67 mV) (coefficient 1.114, 95 % CI 0.43 to 1.80, p = 0.001). Labeled cells were detected in 2/5 (40 %) and 5/5 (100 %) dogs in the M and MBG groups, respectively. Coadministration of bFGF-loaded PCL beads and autologous myoblasts improved the recovery of sphincter function in a dog model of FI and had better outcomes than cell-based therapy alone.</P>
Adipose-derived stem cells on the healing of ischemic colitis: a therapeutic effect by angiogenesis.
Joo, Hyun Ho,Jo, Hye Jung,Jung, Tae Doo,Ahn, Min Sung,Bae, Ki Beom,Hong, Kwan Hee,Kim, Jeong,Kim, Jong Tae,Kim, Sun Hee,Yang, Young Il Springer International ; Springer-Verlag, distribu 2012 International journal of colorectal disease Vol.27 No.11
<P>There has been no specific treatment for ischemic colitis. We verified the effects of adipose-derived stem cells (ASCs) on ischemia-induced colitis in a rat model.</P>
DNA methylation-specific multiplex assays for body fluid identification.
An, Ja Hyun,Choi, Ajin,Shin, Kyoung-Jin,Yang, Woo Ick,Lee, Hwan Young Springer International ; Springer 2013 International journal of legal medicine Vol.127 No.1
<P>Recent advances in whole-genome epigenetic analysis indicate that chromosome segments called tissue-specific differentially methylated regions (tDMRs) show different DNA methylation profiles according to cell or tissue type. Therefore, body fluid-specific differential DNA methylation is a promising indicator for body fluid identification. However, DNA methylation patterns are susceptible to change in response to environmental factors and aging. Therefore, we investigated age-related methylation changes in semen-specific tDMRs using body fluids from young and elderly men. After confirming the stability of the body fluid-specific DNA methylation profile over time, two different multiplex PCR systems were constructed using methylation-sensitive restriction enzyme PCR and methylation SNaPshot, in order to analyze the methylation status of specific CpG sites from the USP49, DACT1, PRMT2, and PFN3 tDMRs. Both multiplex systems could successfully identify semen with spermatozoa and could differentiate menstrual blood and vaginal fluids from blood and saliva. Although including more markers for body fluid identification might be necessary, this study adds to the support that body fluid identification by DNA methylation profiles could be a valuable tool for forensic analysis of body fluids.</P>
Kim, Hye Jin,Choi, Gyu-Seog,Park, Jun Seok,Park, Soo Yeun Springer International ; Springer-Verlag, distribu 2013 International journal of colorectal disease Vol.28 No.1
<P>Recently, a single-stapled technique (SST) was performed instead of the conventional double-stapled technique (DST) in laparoscopic low anterior resection for anastomosis, by placement of intracorporeal purse-string sutures on the distal rectum with transanal specimen extraction. This study aimed to compare the short-term outcomes between the two anastomotic techniques.</P>