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Jo, Sung Duk,Nam, Gi-Hoon,Kwak, Gijung,Yang, Yoosoo,Kwon, Ick Chan ELSEVIER SCIENCE BV AMSTERDAM 2017 Nano Today Vol. No.
<P><B>Abstract</B></P> <P>Although cancer immunotherapy, represented by chimeric antigen receptor (CAR) T-cell therapy and immune checkpoint-blockade therapies, has shown durable outcomes, the percentage of patients that respond to these approaches remains modest to date. However, encouraging recent advances suggest that nanotechnology has the potential to enhance the efficacy of such immunotherapies by improving the delivery, biodistribution, and release-kinetics of immunostimulatory small molecules and biologics in targeted tissues. A variety of synthetic nanoparticles, including polymeric nanoparticles, liposomes and inorganic nanoparticles, can be engineered according to their intended uses in cancer immunotherapy. Notably, nature-derived nanoparticles have emerged as a new class of immunotherapeutics. In this review, we describe state-of-the-art strategies for cancer immunotherapy using designed nanoparticles. We also highlight key translational challenges and opportunities in this rapidly growing field.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Review recent progress in nanotechnology with the potential to enhance the efficacy of cancer immunotherapies by improving delivery to specific target tissues. </LI> <LI> Discuss the characteristics and design parameters of nanoparticle delivery systems that should be considered to maximize efficacy of immunotherapies. </LI> <LI> Overview a variety of nanoparticle platforms, including polymeric and inorganic nanoparticles, liposomes, and nature-derived nanoparticles which can be engineered according to intended uses in cancer immunotherapy. </LI> <LI> Highlight translational challenges and opportunities in the field of nanoparticle-mediated cancer immunotherapy. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Noh, Seung-hyun,Moon, Seung Ho,Shin, Tae-Hyun,Lim, Yongjun,Cheon, Jinwoo ELSEVIER SCIENCE BV AMSTERDAM 2017 Nano Today Vol. No.
<P><B>Abstract</B></P> <P>Magnetic nanoparticle (MNP)-mediated heating systems have emerged as an effective strategy for the fine control of biological systems from hyperthermia to cell signaling in a spatiotemporally controlled fashion. To achieve satisfactory performance, advanced design concepts have been developed to tailor the magnetism that directly affects the heating properties of nanoparticles. In this review, we focus on recent advances in magnetism-engineered nanoparticles. Fundamental principles of magnetic heating mechanisms and related key magnetic parameters are discussed first to provide instructive guidelines for the design of MNPs with enhanced heating efficiency. Then, we highlight recent progress in MNPs for optimized heat generation with unique design approaches to control magnetism. Finally, we discuss highly effective biomedical application studies such as dual-mode magnetic hyperthermia, magnetothermally triggered drug delivery, and the magnetothermal control of cellular activities.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Basic principles of heat dissipation of magnetic nanoparticles. </LI> <LI> Nanoparticle design considerations for tuning the magnetism that governs magnetic heating efficiency, such as specific loss power (<I>SLP</I>). </LI> <LI> Emerging approaches for the use of heat-generating nanoparticles for dual-mode magnetic hyperthermia, magnetothermally triggered drug delivery, and the magnetothermal control of cellular activities. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>