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고지원,박하영,배정모,강준,조의주,이승은,강혜윤,홍민의,원재경,최윤라,김완섭,이아원,The Molecular Pathology Study Group of the Korean Society of Pathologists 대한병리학회 2023 Journal of Pathology and Translational Medicine Vol.57 No.5
Background: The importance of molecular pathology tests has increased during the last decade, and there is a great need for efficient training of molecular pathology for pathology trainees and as continued medical education. Methods: The Molecular Pathology Study Group of the Korean Society of Pathologists appointed a task force composed of experienced molecular pathologists to develop a refined educational curriculum of molecular pathology. A 3-day online educational session was held based on the newly established structure of learning objectives; the audience were asked to score their understanding of 22 selected learning objectives before and after the session to assess the effect of structured education. Results: The structured objectives and goals of molecular pathology was established and posted as a web-based interface which can serve as a knowledge bank of molecular pathology. A total of 201 pathologists participated in the educational session. For all 22 learning objectives, the scores of self-reported understanding increased after educational session by 9.9 points on average (range, 6.6 to 17.0). The most effectively improved items were objectives from next-generation sequencing (NGS) section: ‘NGS library preparation and quality control’ (score increased from 51.8 to 68.8), ‘NGS interpretation of variants and reference database’ (score increased from 54.1 to 68.0), and ‘whole genome, whole exome, and targeted gene sequencing’ (score increased from 58.2 to 71.2). Qualitative responses regarding the adequacy of refined educational curriculum were collected, where favorable comments dominated. Conclusions: Approach toward the education of molecular pathology was refined, which would greatly benefit the future trainees.
Molecular Testing for Gastrointestinal Cancer
이혜승,김우호,곽윤진,고지원,배정모,김경미,장미수,한혜승,김준미,김활웅,장희경,최영희,박지영,구미진,이민진,김정연,김희성,조미연,The Gastrointestinal Pathology Study Group of Korean Society of Pathol,The Molecular Pathology Study Group of Korean Society of 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.2
With recent advances in molecular diagnostic methods and targeted cancer therapies, several molecular tests have been recommended for gastric cancer (GC) and colorectal cancer (CRC). Microsatellite instability analysis of gastrointestinal cancers is performed to screen for Lynch syndrome, predict favorable prognosis, and screen patients for immunotherapy. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor has been approved in metastatic CRCs with wildtype RAS (KRAS and NRAS exon 2–4). A BRAF mutation is required for predicting poor prognosis. Additionally, amplification of human epidermal growth factor receptor 2 (HER2) and MET is also associated with resistance to EGFR inhibitor in metastatic CRC patients. The BRAF V600E mutation is found in sporadic microsatellite unstable CRCs, and thus is helpful for ruling out Lynch syndrome. In addition, the KRAS mutation is a prognostic biomarker and the PIK3CA mutation is a molecular biomarker predicting response to phosphoinositide 3-kinase/AKT/mammalian target of rapamycin inhibitors and response to aspirin therapy in CRC patients. Additionally, HER2 testing should be performed in all recurrent or metastatic GCs. If the results of HER2 immunohistochemistry are equivocal, HER2 silver or fluorescence in situ hybridization testing are essential for confirmative determination of HER2 status. Epstein-Barr virus–positive GCs have distinct characteristics, including heavy lymphoid stroma, hypermethylation phenotype, and high expression of immune modulators. Recent advances in next-generation sequencing technologies enable us to examine various genetic alterations using a single test. Pathologists play a crucial role in ensuring reliable molecular testing and they should also take an integral role between molecular laboratories and clinicians.
MOLECULAR CLONING AND CHARACTERIZATION OF A β-1,3-GLUCANASE INDUCED BY WOUNDING AND FUNGAL ELICITOR
Cheong, Yong-Hwa,Kim, Cha-Young,Chun, Hyun-Jin,Han, Chang-Deok,Hong, Jong-Chan,Bahk, Jeong-Dong,Cho, Moo-Je Plant Molecular Biology & Biotechnology Research C 1995 Plant molecular biology and biotechnology research Vol.1995 No.
Chung, Jun Ho 가톨릭 의과학연구원 2002 가톨릭 의과학연구원 국제학술대회 Vol.6 No.-
The use of RT-PCR to identify tumor-associated mRNA is currently believed to be the most sensitive means of identifying circulating tumor cells in cancer patients. One of the newer areas being explored in the management of cancer is the use of RT-PCR to analyze the blood of cancer patients for the detection of mRNA expressed in tumor cells. This technology may aid in three major areas in the management of cancer: 1) predicting which patients will have a favorable outcome following removal/treatment of the primary lesion, 2) more efficiently analyzing ways to follow the efficacy of therapy, and 3) detecting relapsing tumors at its very early stage.
Induction of Peripheral Tolerance in Dual TCR T Cells
Hah, Chae-Rim,Kim, Mi-Hyung,Kim, Kil-Hyoun 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14
Recently, the existence of T cells with dual T cell receptor (TCR) in the immune system is generally accepted, while it has been controversial whether signals through one TCR would affect the functions of the other. In this study T cells expressing two different TCR were obtained from cross hybrids of LCMV and AND TCR transgenic mice specific for the gp^(33) and peptide fragment of PCC (fPCC), respectively. Peptide stimulation demonstrated that the dual TCR T cells functioned independently in an antigenspecific manner. To examine whether the tolerance targeted for the one TCR affects the responsiveness of the other, the cross-hybrids were treated with gp^(33). Although T cells from F1 mice were rendered anergenic to gp^(33), no functional changes to fPCC were observed in terms of cellular proliferation and IL-2 secretion, suggesting that the dual TCR T cells remained reactive to fPCC. We therefore propose that signaling through the TCR is receptor-specific and 'negative dominance' of one TCR by tolerance induction is not applicable in this dual TCR system.