풍향에 따른 아파트 단지내 기체유동 및 온도 분포해석

변용섭,조재광,엄태인,장재덕,이상길 大田産業大學校 2000 한밭대학교 논문집 Vol.17 No.1

In this study, velocity and temperature profiles are calculated on the apartment complex at Dunsan area in Taejon using FLUENT code based on computational fluid dynamics (CFD). Input weather conditions which maximum atmospheric is 38.6℃, wind speed is 1.7m/sec, wind direction is west-south-west and maximum wall of apartment is 58.0℃ in summer are used to calculate the results. The simulation results are as follow ; First. velocity vectors at vertical cross section of apartment complex are influenced by the thermal buoyancy force in hot wall of apartment due to weak wind speed in the case of wind direction : west-south-west, south-west, west. Second, temperature profiles at vertical cross section of apartment complex are strongly influenced by the wind direction. Atmospheric temperature in wide area is higher 1℃ in south-west wind direction than west wind direction. Calculation results show that island in enormous apartment complex in summer. Third, temperature profiles at horizontal cross section of apartment complex present wider and more definite high temperature area than at vertical cross section of apartment complex according to wind direction. This consequence shows the effect of convective heat transfer in the rear heated wall of apartment is dominant by solar radiation. Fourth, It is necessary that an arrangement of apartments with a view of wind direction and distance of each apartments to reduce heat island in apartment and industrial factory complex in the condition of same apartment direction and area capacity. And an arrangement of apartments considering wind direction is able to enhance convective heat transfer between heated wall and wind.

Celay/In-Ceram, Conventional In-Ceram, Empress 2 전부도재관의 변연적합도에 관한 비교 연구

양재호,여인성,이선형,한중석,이재봉,Yang, Jae-Ho,Yeo, In-Sung,Lee, Sun-Hyung,Han, Jung-Suk,Lee, Jai-Bong 대한치과보철학회 2002 대한치과보철학회지 Vol.40 No.2

There have been many studies about marginal discrepancy of single restorations made by various systems and materials. But many of statistical inferences are not definite because of sample size, measurement number, measuring instruments. etc. The purpose of this study was to compare the marginal adaptations of the anterior single restorations made by different systems and to consider more desirable statistical methods in analysing the marginal fit. The in vitro marginal discrepancies of three different all-ceramic crown systems (Celay In-Ceram. Conventional In-Ceram. IPS Empress 2 layering technique) and one control group (PFM) were evaluated and compared. The crowns were made from one extracted maxillary central incisor prepared with a 1mm shoulder margin and $6^{\circ}$ taper walls by milling machine. 10 crowns per each system were fabricated. Measurements or a crown were recorded at 50 points that were randomly selected for marginal gap evaluation. Non-parametric statistical analysis was performed for the results. Within the limits of this study, the following conclusions were drawn: 1 Mean gap dimensions and standard deviations at the marginal opening for the maxillary incisor crowns were $98.2{\pm}40.6{\mu}m$ for PFM, $83.5{\pm}18.7{\mu}m$ for Celay In-Ceram, $104.9{\pm}44.1{\mu}m$ for conventional In-Ceram, and $45.5{\pm}11.5{\mu}m$ for IPS Empress 2 layering technique. The IPS Empress 2 system showed the smallest marginal gap (P<0.05). The marginal openings of the other three groups were not significantly different (P<0.05). 2 The marginal discrepancies found in this study were all within clinically acceptable standards ($100\sim150{\mu}m$). 3. When the variable is so controlled that the system may be the only one, mean value is interpreted to be the marginal discrepancy of a restoration which is made by each system and standard deviation is to be technique-sensitivity of each one. 4. From the standard deviations. the copy-milling technique (Celay/In-Ceram) was not considered to be technique-sensitive in comparison with other methods. 5. Parametric analysis is more reliable than non-parametric one in interpretation of the mean and standard deviation. The sample size of each group has to be more than 30 to use parametric statistics. The level of clinically acceptable marginal fit has not been established. Further studies are needed.

내경동맥 지배 영역의 급성 허혈성 뇌졸중 환자에서 초 선택적 국소적 Urokinase주입술

김인규,김명규,김재규,조기현,김세종 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

In_xGa_1-xN/GaN 다중양자우물 구조의 광학적 성질 연구

김기홍,김인수,박헌보,배인호,유재인,장윤석,Kim, Ki-Hong,Kim, In-Su,Park, Hun-Bo,Bae, In-Ho,Yu, jae-In,Jang, Yoon-Seok 한국진공학회 2009 Applied Science and Convergence Technology Vol.18 No.1

$In_xGa_{1-x}N$/GaN 다중양자우물 구조의 EL 특성을 온도와 주입전류 변화에 따른 특성을 조사하였다 저전류와 고전류 주입시 EL 효율의 온도 의존 변화는 매우 다르게 나타나는데, 이러한 온도와 전류의 변화에 의한 독특한 EL 효율의 변화는 내부전기장의 존재 하에 순방향 바이어스에 기인한 외부전기장의 영향인 것으로 볼 수 있다. 그리고 $In_xGa_{1-x}N$/GaN 다중양자우물 구조에서 In 성비의 증가는 발광파장위치의 적색이동을 보였다. 15K에서 주입 전류의 증가에 따라 녹색 양자우물 구조는 80 meV와 청색 양자우물 구조는 22 meV의 청색 편이를 하였다. 이는 전류의 증가에 의해 단위 시간당 생성되는 캐리어 수가증가하게 되고 그에 따라 subband가 급격히 채워지는 band filling 현상이 일어나게 되어 짧은 파장에서 재결합이 증가하기 때문이다. 그리고 청색과 녹색 다중 양자우물구조의 짧은 파장 쪽으로의 편이 차이는 In 농도에 기인한 것으로 In 농도가 높으면 양자우물 깊이가 증가되어 더 강한 양자속박효과가 작용하여 캐리어 구속력이 증가하기 때문 것으로 볼 수 있다. Temperature and injection current dependence of electroluminescence(EL) spectral intensity of the $In_xGa_{1-x}N$/GaN multi-quantum wells(MQW) have been studied over a wide temperature range and as a function of injection current level. It is found that a temperature-dependent variation pattern of the EL efficiency under very low and high injection currents shows a drastic difference. This unique EL efficiency variation pattern with temperature and current can be explained field effects due to the driving forward bias in presence of internal(piezo and spontaneous polarization) fields. Increase of the indium content in $In_xGa_{1-x}N$/GaN multiple quantum wells gives rise to a redshift of 80 meV and 22 meV for green and blue MQW, respectively. It can be explained by carrier localization by potential fluctuation of multiple quantum well and MQW structures also shows a keen difference owing to the different indium content in InGaN/GaN MQW.

<i>In vitro</i> and <i>in vivo</i> evaluation of a novel polymer-free everolimus-eluting stent by nitrogen-doped titanium dioxide film deposition

Park, Dae Sung,Bae, In-Ho,Jeong, Myung Ho,Lim, Kyung Seob,Sim, Doo Sun,Hong, Young Joon,Lee, So-Youn,Jang, Eun Jae,Shim, Jae-Won,Park, Jun-Kyu,Lim, Han Chul,Kim, Han Byul Elsevier 2018 Materials Science and Engineering C Vol.91 No.-

<P><B>Abstract</B></P> <P>Inflammation and thrombosis are linked to the use of polymer-based drug-eluting stents (DES). The aim of this study was to develop a polymer-free everolimus (EVL)-eluting stent using nitrogen-doped titanium dioxide (N-TiO<SUB>2</SUB>) and verify its efficacy by <I>in vitro</I> and <I>in vivo</I> assessment in a porcine coronary model. Various analytical approaches such as scanning electron microscopy and atomic force microscopy, electron spectroscopy, Fourier transform infrared spectrometry and contact angle measurement were employed for the characterization. As a part of biocompatibility assessment, platelet adhesion and smooth muscle cell (SMC) proliferation were examined. Bare metal stent (BMS), N-TiO<SUB>2</SUB> stent, everolimus-eluting N-TiO<SUB>2</SUB> (N-TiO<SUB>2</SUB>-EVL) stent, and commercialized EVL-eluting stent (EES) were randomly placed in forty coronary arteries in twenty pigs. After four weeks of implantation, the stents were subjected to histological and quantitative analysis. The N-TiO<SUB>2</SUB> film used in this study was well coated without any cracks or peeling. Surface hydrophilicity (88.8% of angle decrement) could be associated with the decrease in surface roughness post N-TiO<SUB>2</SUB> deposition (37.0%). The platelet adhesion on the N-TiO<SUB>2</SUB> surfaces was less than that on the BMS surface. The proliferation of SMC was suppressed in the N-TiO<SUB>2</SUB>-EVL group (30.2%) but not in the BMS group. In the animal study, the percent area restenosis was significantly decreased in the N-TiO<SUB>2</SUB>-EVL group compared to that in the BMS group. The results (BMS; 47.0 ± 11.00%, N-TiO<SUB>2</SUB>-EVL; 31.7 ± 10.50%, and EES; 29.1 ± 11.21%, <I>n</I> = 10, <I>p</I> < 0.05) were almost at par with those of the commercialized EVL-eluting stent. The introduction of N-TiO<SUB>2</SUB> deposition during fabrication of polymer-free DES may be an efficient accessorial process for preventing in-stent restenosis and thrombosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> N-TiO<SUB>2</SUB> surfaces can help to reduce the platelet adhesion. </LI> <LI> In porcine model, N-TiO<SUB>2</SUB> everolimus decreased in-stent restenosis and fibrin deposition. </LI> </UL> </P>

Poster Session : PS 1015 ; GI Motility : Pegylated-Photosensitizer Enhances the Effi cacy of Photodynamic Therapy Through Escaping of ATPBinding Cassette Subfamily G Member 2 in Pancreatic Cancer Cells

( Jae Myung Park ),( In Wook Kim ),( Ju Hee Kim ),( Tayyaba Hasan ),( Myung Gyu Choi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Porphyrin-based photosensitizers are most commonly used in photodynamic therapy (PDT). However, these drugs are exported extracellularly by a cell-membrane transporter, the ATP-binding cassette subfamily G member 2 (ABCG2), decreasing the PDT-induced cytotoxicity in cancer treatment. In this study, we showed that intracellular level of a porphyrin was increased by its Pegylated form, which enhance the PDT-induced cytotoxicity. Methods: Pancreatic cancer cells, AsPC-1 and MIA PaCa-2, were selected. We also used ABCG2-overexpressed MIA Paca-2 cells. We pretreated them with chlorine e6 (Che6) or its pegylated-Che6, then irradiated with a diode laser emitting at 670 nm wave length with total radiation dose of 6 J/cm2. We measured the intracellular level of Che6 and peglated-Che6 with fl uorescence meter, FACS and confocal microscope. Cell viability and survival was analyzed by MTT assay and clonogenic survival assay, respectively. Singlet oxygen level was quantified with photomultiplier-tube based singlet oxygen detection system. In-vivo PDT effects were investigated with AsPC-1 cell-bearing BALC/nude mice of the Che6 and pegylated-Che6. Results: The intracellular level of Che6 was higher in MIA PaCa-2 than AsPC-1 and MIA PaCa-2/ABCG2 cells. However, intracellular level of Che6 was increased by its pegylated form in AsPC-1 and MIA PaCa2/ABCG2 cells. Cell viability after PDT was signifi cantly decreased in MIA PaCa-2 compared to AsPC-1 and MIA PaCa-2/ABCG2. However, PDT using pegylated-Che6 caused the similar cytotoxicity among the three cancer cell lines. The production level of singlet oxygen was higher in pegylated-Che6 than Che6-treated cells. The tumor volume after PDT using pegylated-Che6 was signifi cant smaller than that of Che6 in AsPC-1-xenograft mouse model. Conclusions: Pegylated-photosensitizer escaped ABCG2 function, which suggests potential improvement of ABCG2-related resistant to porphyrin-based PDT in cancer treatment in pancreatic cancers.

공군사관생도의 심폐능력에 따른 심리 · 생리요인 비교

김인기(In-ki Kim),김건희(Gun-hee Kim),송성우(Sung-woo Song),최가람(Ga-ram Choi),엄장원(Jang-won Eom),곽재준(Jae-jun Kwak),유영남(Young-nam You),정덕화(Deok-hwa Jeong),강지훈(Ji-hun Kang) 육군사관학교 화랑대연구소 2019 한국군사학논집 Vol.75 No.2

The purpose of this study was to analyze the differences in psychological and physiological factors between groups by classifying groups based on the 3km running record of fourth grade Air Force Academy cadets. Among the top 46 Air Force Academy cadets who wanted to participate in the study, the study conducted an open survey of the top 13 and the bottom 15 who wanted to provide the data prior to the study. The subjects of the experiment and in-depth interview were studied by a total of 18 people, 9 of each upper and lower members who wished to participate in the study. Psychological factors were structured through inductive content analysis of data extracted from in-depth interviews, and physiological factors were conducted to verify differences between groups of body composition and cardiopulmonary function. The psychological factors of the upper and lower groups were found to be general areas of performance strategy, achievement motivation, emotional response, military spirit, situation perception, and basic physical strength. In the detailed areas, the subjects were also examined in 15 areas including physical fitness indicators, confidence, condition control, task orientation, and positive self-perception. As a result of comparison between upper and lower groups, the upper group was 2.2 times higher than the lower group and the lower group was 1.7 times higher than the upper group in the military spirit and performance strategy of the general area response rate. In general area response, the ratio of mental strength and confidence was different in the general area of military spirit. In addition, the upper group in the achievement motivation showed a high percentage of task tendency at 47%, while the lower group showed a high rate of zero motivation at 50%. In the emotional response, the upper group showed an equal ratio, while the lower group showed an 81% ratio of negative emotions. In the overall response by sub-region, the negative emotions of the subgroup were high at 28%. In the body composition, BFM showed a statistically significant difference between upper and lower groups, and Weight, FFM, and SMM did not show any significant difference between groups. In cardiopulmonary capacity, VO2max showed a statistically significant difference between upper and lower groups, and VE and LT did not show significant differences between groups.

Anthracycline제재로 치료받은 종양환아에서 QT분산

고재곤,김영휘,박인숙,서종진,문형남 대한소아과학회 2001 小兒科 Vol.44 No.8

Treadmill 부하 Program 영역이 성인비만여성의 신체조성에 미치는 영향

이석인,박재석 중앙대학교 스포츠과학연구소 2003 體育硏究 Vol.- No.18

The purpose of this study is to compare the difference between the treadmill load during the oxygen-consuming exercise and constant velocity oxygen-consuming treadmill program through controlling the velocity after setting the treadmill load during the oxygen-consuming exercise in several stages subjecting the adult fat women group(Fat)30%, N=10), and then to provide the basic data to develop the adequate treadmill exercise program which can decrease the fat risk with the base of the change of the physical composition(body weight, body fat rate, body fat volume, total fat rate, and body water volume) of the adult fat women group. The 10 minutes of the warming-up exercise, 10 minutes of the summary exercise, and the main exercise(treadmill load program, constant velocity treadmill program) was set as 25 ~ 45 minutes according to the individual difference, and the subject people were asked to walk or run according to the treadmill program, and the intensity of the exercise was applicable to 65 ~ 90% of the maximum cardiac pulse frequency, that is, in the extent of 65 ~ 90% of HRmax the program was executed. In order to examine the difference between before and after the exercise, the paired t-test was applied, and in order to examine the influence on effects of the individual group(group), between before and after the event(time), and group and the interaction between before and after the event(group x time), the two-way ANOVa which is the examination for the average difference of the estimated variable was executed, and the acceptance standard for the proposition was set up as P〈.05. 1. In the group of the treadmill load program, the body weight was decreased between before and after the exercise(P〈.01), and in the group of the constant velocity treadmill program, the body weight was decreased between before and after the exercise(P〈.05). Additionally, the influence on the body weight in each group didnot show the meaningful difference statistically among those groups, but there was very meaningful difference between before and after the exercise(P〈.001), and there was no meaningful difference in the interaction about between the before and after exercise and among groups. 2. In the group of the treadmill load program, the body fat rate was decreased between before and after the exercise(P〈.05), and in the group of the constant velocity treadmill program, the body fat rate was decreased between before and after the exercise, but there was no meaningful difference. Additionally, the influence on the body fat rate in each group did not show the meaningful difference statistically among those groups, but there was very meaningful difference between before and after the exercise(P〈.01), and there was no meaningful difference in the interaction about between the before and after exercise and among groups. 3. In the group of the treadmill load program, the body fat volume was decreased between before and after the exercise(P〈.01), and in the group of the constant velocity treadmill program, the body fat volume was decreased between before and after the exercise(P〈.05). Additionally, the influence on the body fat volume in each group did not show the meaningful difference statistically among those groups, but there was very meaningful difference between before and after the exercise(P〈.001), and there was no meaningful difference in the interaction about between the before and after exercise and among groups. 4. In the group of the treadmill load program, the body fat volume was increased between before and after the exercise(P〈.01), and in the group of the constant velocity treadmill program, the body fat volume was decreased between before and after the exercise(P〈.05), but there was no meaningful difference. Additionally, the influence on the body fat volume in each group did not show the meaningful difference statistically among those groups, and there was no meaningful difference in the interaction about between the before and after exercise and among groups. 5. In the group of the treadmill load program, the body water volume was decreased between before and after the exercise, and in the group of the constant velocity treadmill program, the body water volume was decreased between before and after the exercise, but there was no meaningful difference. Additionally, the influence on the body water volume in each group did not show the meaningful difference statistically among those groups, and there was no meaningful difference in the interaction about between the before and after exercise and among groups.

뇌의 신경교종과 수막종에서 성장촉진 인자와 증식세포핵항원(PCNA)에 관한 연구

심재갑,김인선,구병삼 고려대학교 의과대학 1992 고려대 의대 잡지 Vol.29 No.1

A recent revolutionary study in molecular biology leads to understand that growth factors are necessary for normal development and the function of the cells. It has also found that many of the growth factors or their respective receptors are related to products of transforming viral genes and normal cellular counterparts called proto-oncogenes. The activation of proto-oncogenes results in growth factor secretion or growth factor receptor expression. The concommitant expression of growth factors and of their receptors results in autocrine growth stimulation, related to the development of human cancers. In this study, the presence of estrogen receptor (ER-D_(5)) and epidermal growth factor receptor(EGFR). expression of c-myc protein. and the positivity of proliferating cell nuclear antigen (PCNA) were evaluated in 26 cases of low grade (13) and high grade (7) astrocytomas and glioblastoma multiforme (6), and 22 cases of meningiomas, by immunohistochemical staining on paraffin sections. The results are summerized as follows : 1. ER-D_(5) was positive in 9 among 22 cases of meningioma (40.9%), and in 4 among 26 cases of astrocytoma and glioblastoma multiforme (19.2%). 2. EGFR was positive in 20 of 22 meningiomas (90.9%), and 20 of 26 astrocytomas and glioblastoma multiforme than in low grade tumors. 3. C-myc protein was positive in all, except one, meningiomas and all malignant astrocytomas and glioblastoma multiforme. However, it was only positive in 8 among 13 cases of low grade astrocytoma (61.5%). The positivity was higher in the meningotheliomatous type of meningiomas than in other histologic types, and also higher in malignant astrocytomas and glioblastoma multiforme than in low grade astrocytomas. 4. The PCNA-positive cells were absent or rarely seen in one case of meningiomas and 8 of 13 cases of low grade astrocytomas. The proportion of positive cells was higher in the meningotheliomatous type of meningiomas than in others, and higher in malignant astrocytomas and glioblastoma multiforme than in low grade astrocytomas. 5. There was a positive correlation between the expressibility of EGFR, c-myc protein, and PCNA. The degree of positivity was higher in malignant forms of glial tumors.