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        Anti-Inflammatory and Cicatrizing Activities of a Carbohydrate Fraction Isolated from Sugary Kefir

        M.E.C. Moreira,M.H. Dos Santos,G.P.P. Zolini,A.T.B. Wouters,J.C.T. Carvalho,J.M. Schneedorf 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2

        Kefir is an association of microrganisms generally grown in milk, with known probiotic activities identifiedfrom its soured suspensions. Aqueous media are also able to grow kefir, but little is known about the probiotic properties ofits fermented products. This work aimed to evaluate some probiotic properties of a carbohydrate fraction isolated from sug-ary kefir (sugary kefir carbohydrate [SKC]). Anti-inflammatory activity of the isolated fraction of carbohydrate was testedboth in vitro(cellular respirometry and macrophage culture) and in vivo (50% effective dose, rat paw edema, vascular per-meability, and cicatrizing test). The results indicated no significant difference for oxygen uptake or macrophage culture be-tween control and test groups. Rat paw edema, however, showed a significant inhibitory activity by 30. 4% and 54 . 8%(P. .001) for carrageenan and dextran, respectively. In the cicatrizing test, animals treated with SKC cream also presentedless trauma after treatments as compared to the negative control group (P. .05). The overall data suggested the SKC as anatural product that could be used as a constituent of an anti-inflammatory compound.

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