http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Ziyu Fan (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Ziyu Song,Meng Jin,Shenglong Wang,Yanzuo Wu,Qi Huang,Wangda Xu,Yongsheng Fan,Fengyuan Tian The Korean Society of Ginseng 2024 Journal of Ginseng Research Vol.48 No.2
Background: Deposition of immune complexes drives podocyte injury acting in the initial phase of lupus nephritis (LN), a process mediated by B cell involvement. Accordingly, targeting B cell subsets represents a potential therapeutic approach for LN. Ginsenoside compound K (CK), a bioavailable component of ginseng, possesses nephritis benefits in lupus-prone mice; however, the underlying mechanisms involving B cell subpopulations remain elusive. Methods: Female MRL/lpr mice were administered CK (40 mg/kg) intragastrically for 10 weeks, followed by measurements of anti-dsDNA antibodies, inflammatory chemokines, and metabolite profiles on renal samples. Podocyte function and ultrastructure were detected. Publicly available single-cell RNA sequencing data and flow cytometry analysis were employed to investigate B cell subpopulations. Metabolomics analysis was adopted. SIRT1 and AMPK expression were analyzed by immunoblotting and immunofluorescence assays. Results: CK reduced proteinuria and protected podocyte ultrastructure in MRL/lpr mice by suppressing circulating anti-dsDNA antibodies and mitigating systemic inflammation. It activated B cell-specific SIRT1 and AMPK with Rhamnose accumulation, hindering the conversion of renal B cells into plasma cells. This cascade facilitated the resolution of local renal inflammation. CK facilitated the clearance of deposited immune complexes, thus reinstating podocyte morphology and mobility by normalizing the expression of nephrin and SYNPO. Conclusions: Our study reveals the synergistic interplay between SIRT1 and AMPK, orchestrating the restoration of renal B cell subsets. This process effectively mitigates immune complex deposition and preserves podocyte function. Accordingly, CK emerges as a promising therapeutic agent, potentially alleviating the hyperactivity of renal B cell subsets during LN.
-
Experimental Study on Bond Behavior between Section Steel and RAC under Full Replacement Ratio
Chao Liu,Ziyu Fan,Xiaona Chen,Chao Zhu,Haiyang Wang,Guoliang Bai 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.3
Nine specimens of steel reinforced recycled concrete are designed to explore the effect of four factors as the cover thickness of section steel, the embedded length of section steel, the recycled aggregate concrete strength, and the lateral stirrup ratio on bond slip between section steel and recycled aggregate concrete. The test results show that the failure modes of recycled aggregate concrete are as similar as normal concrete; three formulas are proposed for the bond stress between section steel and recycled aggregate concrete, which are fitting well. The mathematical model of bond stress-slip is established through analysis, and the predicted curve is close to the test curve. The research results provide the basis for the numerical simulation analysis of the bond slip for the recycled aggregate concrete under the full replacement ratio.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
