Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner

Ziyu Song,Meng Jin,Shenglong Wang,Yanzuo Wu,Qi Huang,Wangda Xu,Yongsheng Fan,Fengyuan Tian The Korean Society of Ginseng 2024 Journal of Ginseng Research Vol.48 No.2

Background: Deposition of immune complexes drives podocyte injury acting in the initial phase of lupus nephritis (LN), a process mediated by B cell involvement. Accordingly, targeting B cell subsets represents a potential therapeutic approach for LN. Ginsenoside compound K (CK), a bioavailable component of ginseng, possesses nephritis benefits in lupus-prone mice; however, the underlying mechanisms involving B cell subpopulations remain elusive. Methods: Female MRL/lpr mice were administered CK (40 mg/kg) intragastrically for 10 weeks, followed by measurements of anti-dsDNA antibodies, inflammatory chemokines, and metabolite profiles on renal samples. Podocyte function and ultrastructure were detected. Publicly available single-cell RNA sequencing data and flow cytometry analysis were employed to investigate B cell subpopulations. Metabolomics analysis was adopted. SIRT1 and AMPK expression were analyzed by immunoblotting and immunofluorescence assays. Results: CK reduced proteinuria and protected podocyte ultrastructure in MRL/lpr mice by suppressing circulating anti-dsDNA antibodies and mitigating systemic inflammation. It activated B cell-specific SIRT1 and AMPK with Rhamnose accumulation, hindering the conversion of renal B cells into plasma cells. This cascade facilitated the resolution of local renal inflammation. CK facilitated the clearance of deposited immune complexes, thus reinstating podocyte morphology and mobility by normalizing the expression of nephrin and SYNPO. Conclusions: Our study reveals the synergistic interplay between SIRT1 and AMPK, orchestrating the restoration of renal B cell subsets. This process effectively mitigates immune complex deposition and preserves podocyte function. Accordingly, CK emerges as a promising therapeutic agent, potentially alleviating the hyperactivity of renal B cell subsets during LN.

VCPU-PCPU Mapping with Various Selection Permission in Cloud Computing

Ziyu Fang,Cheulwoo Ro 한국정보통신학회 2018 2016 INTERNATIONAL CONFERENCE Vol.10 No.1

The effective allocation of resources is important in the virtual system. This paper mainly describes the different processing power, how to carry out the effective allocation of resources and performance analysis in models with selectable permissions and fully free random allocation of resources. The PCPUs have different processing speed, and the VCPUs have the different number of cores in order to simulate the real environment. Compared with VCPU-PCPU mapping with full selection permission, VCPU-PCPU mapping with various selection permission is more efficient and stable in most cases.

2P-587 충전제 탄산칼슘과 이산화티탄의 혼합및 개질에 따른 종이 물성과 광학적 성질

( Ziyue Mo ),조준형,( Lijun Wang ) 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1

The current data shows that the consumption of inorganic filler in papermaking process is in a increasing trend. For the sake of reduction of cost, this inorganic filler was added to the papermaking as the core material, meanwhile, the smoothness, opacity and other property can be improved. Especially, GCC, PCC, TiO₂ are the most common filler for increasing the paper opacity. Although the paper made by TiO₂ let paper get higher opacity than GCC, PCC, the high cost is its weakness. There are many advanced composite and material made from raw material. The less new material is used in the paper, the better property is got. In this study, not only to further improve paper opacity but also to cut down the cost, PCC and GCC were surface modified with TiO₂ through Hibridizer. While the material made though this process was adding in the papermaking process, the optical property and strength property can be commanded, especially opacity.

The associations of obesity phenotypes with the risk of hypertension and its transitions among middle-aged and older Chinese adults

Ziyue Sheng,Shang Lou,Jin Cao,Weidi Sun,Yaojia Shen,Yunhan Xu,Ziyang Ren,Wen Liu,Qian Yi,Peige Song 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: This study aimed to investigate the associations of obesity phenotypes with hypertension stages, phenotypes, and transitions among middle-aged and older Chinese. METHODS: Using the 2011-2015 waves of the China Health and Retirement Longitudinal Study, we conducted a cross-sectional analysis included 9,015 subjects and a longitudinal analysis included 4,961 subjects, with 4,872 having full data on the hypertension stage and 4,784 having full data on the hypertension phenotype. Based on body mass index and waist circumstance, subjects were categorized into 4 mutually exclusive obesity phenotypes: normal weight with no central obesity (NWNCO), abnormal weight with no central obesity (AWNCO), normal weight with central obesity (NWCO), and abnormal weight with central obesity (AWCO). Hypertension stages were classified into normotension, pre-hypertension, stage 1 hypertension, and stage 2 hypertension. Hypertension phenotypes were categorized as normotension, pre-hypertension, isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic-diastolic hypertension (SDH). The association between obesity phenotypes and hypertension was estimated by logistic regression. A comparison between different sexes was conducted by testing the interaction effect of sex. RESULTS: NWCO was associated with normal→stage 2 (odds ratio [OR], 1.95; 95% confidence interval [CI], 1.11 to 3.42), maintained stage 1 (OR, 1.62; 95% CI, 1.14 to 2.29), and normal→ISH (OR, 1.39; 95% CI, 1.05 to 1.85). AWCO was associated with normal→stage 1 (OR, 1.75; 95% CI, 1.40 to 2.19), maintained stage 1 (OR, 2.77; 95% CI, 2.06 to 3.72), maintained stage 2 (OR, 2.80; 95% CI, 1.50 to 5.25), normal→ISH (OR, 1.56; 95% CI, 1.20 to 2.02), and normal→SDH (OR, 2.54; 95% CI, 1.72 to 3.75). An interaction effect of sex existed in the association between obesity phenotypes and hypertension stages. CONCLUSIONS: This study highlights the importance of various obesity phenotypes and sex differences in hypertension progression. Tailored interventions for different obesity phenotypes may be warranted in hypertension management, taking into account sex-specific differences to improve outcomes.

Removal of PAHs in contaminated soil using electrical resistance heating: removal efficiency and alteration of soil properties

Ziyu Han,Wentao Jiao 대한환경공학회 2019 대한환경공학회 학술발표논문집 Vol.2019 No.-

Friction-induced exfoliation of graphene sheets through varying a coating layer thickness

Ziyu Cong(총자우),Seungjun Lee(이승준) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.4

Radar-absorbing Performances of Camouflage Fabrics with 3D Warp-knitted Structures

Ziyu Zhao,Pibo Ma,Haitao Lin,Fenglin Xia 한국섬유공학회 2020 Fibers and polymers Vol.21 No.3

In this paper, 3D warp-knitted camouflage fabrics were fabricated with two kinds of bottom structure. Polyesterand coating treated PE flat wire were used as raw materials. The samples were manufactured by the RD6N warp-knittingmachine. The properties of camouflage fabrics were tested and analyzed. Results show that the lowest reflection loss of 2 cmheight of 3D warp-knitted camouflage fabrics with mesh was -38.49 dB at 15.45 GHz. And the 3D warp-knitted camouflagefabric has excellent absorption performance, tensile breaking strength and flame retardant property. The findings havetheoretical and practical significance for the applications of 3D warp-knitted camouflage fabrics.

A Study on the Return Phenomenon of China Overseas Talent Studying in the Post-Epidemic Era

Ziyu Zhang,Huang Yang,Yuzhu Duan KOREA INSTITUTE FOR HUMANITIES AND SOCIAL SCIENCES 2024 Journal of Global Area Studies Review(GAS) Vol.3 No.1

China has been committed to attracting and retaining overseas Chinese students in order to promote innovation and development in the country. The Central Organization Department has developed a series of policies and initiatives aimed at supporting overseas Chinese students in their innovation and entrepreneurship in China. However, covid-19 has had an impact on the phenomenon of overseas Chinese students returning home, which has also raised concerns. Objective: This study aims to explore the policy initiatives of the Central Organization Department and the changing trends of the phenomenon of overseas Chinese students returning home, with a view to providing useful references for China in attracting and retaining overseas Chinese students. Methods: Through literature review and policy analysis, an in-depth analysis was conducted on the policy initiatives of the Central Organization Department and the phenomenon of overseas Chinese students returning to China. Results: The study found that the Central Organization Department set strategic goals in supporting key national innovation projects, focusing on supporting innovation and entrepreneurship of top overseas Chinese students in China. Meanwhile, the phenomenon of overseas Chinese students returning to China after COVID-19 shows a certain trend of change. Conclusion: Research findings indicate that the COVID-19 pandemic has spurred a wave of overseas Chinese students’ returning to China which increases the domestic supply of talent. Governments and educational institutions should provide more support to those graduates adapting to the domestic employment market. What’s more, overseas Chinese students should actively seek opportunities, enhance their competitiveness, adapt flexibly to market changes, and prepare for future career aspirations.

Structural analysis of BNNT-reinforced aluminum composites: a molecular dynamics simulation

Ziyu Cong(총자우),Seungjun Lee(이승준) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12

Net-Zero Energy Building Optimization Based on Simulation by African Vulture Optimization Algorithm: Cases of Italy

Wang Ziyu,Yin Haoyu,Baniotopoulos Charalampos,Zafetti Nicholas 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.6

Obtaining the optimum integration of design policies is the target in net-zero energy buildings. This is designed to solve the energy operation problems in a specific building. A multi-objective optimization method is proposed in this paper for net-zero energy building operation optimization to achieve the best design solution among Pareto set solutions. This method is based on simulation and includes simulation of the building, optimization, multi-criteria decision-making approach, and sensitivity analysis to confirm the validity of the optimum results. Some cases of Italy with various climatic conditions are selected to be investigated in terms of the cost-efficiency potential to optimize the net-zero energy building design. To improve this design and to help decision-making in the early design steps of the building, the presented method can be efficient. For the minimization of the electrical, and thermal demands and also life cycle costs while obtaining net-zero energy balance, an optimization algorithm called African Vulture Optimization Algorithm is proposed. Also, to achieve an optimum solution, the Elimination and Choice Expressing the Reality method is used in the Pareto set. Based on the best design variables and their related objective functions, in comparison to the base case, the yearly thermal loads lowered from 18.9 to 33.5% by optimum designs, and the solar domestic hot water electrical power use lowered up to 7.6% and the life cycle cost is decreased up to 14.7%.