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Chu, Xiao,Zhu, Cheng-Chu,Liu, Hui,Wang, Jiao-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Purpose: To investigate the expression of hypoxia-inducible factor prolyl hydroxylase 3 (HIFPH3) in non-small cell lung cancer (NSCLC) and explore the correlation of HIFPH3 expression with lymph node metastasis and microvessel density (MVD). Materials and Methods: A total of 73 cases of NSCLC specimens, 24 cases of para-cancerous tissues, and 20 normal pulmonary tissues were collected for HIFPH3 and CD31 immunohistochmical (IHC) study. Microvessel density (MVD) of the NSCLC tissues was also determined based on the expression of CD31. Results: The expression of HIFPH3 in carcinoma tissue was statistically higher than para-cancerous and normal pulmonary tissues (${\chi}^2=48.806$, p<0.05). Compared withthe negative lymph node metastasis group, the lymph node metastasis group showed significantly higher HIFPH3 expression (${\chi}^2=6.300$, p<0.05). The strong HIFPH3+group displayed a significantly higher MVD than weak HIFPH3+ and HIFPH3- groups (p<0.05). No differences in positive HIFPH3 expression were noted regarding the tumor diameter, age, smoking status, gender of NSCLC patients, tumor size, histopathology, or differentiation. Conclusions: HIFPH3 expression in human NSCLC lesions is significantly higher than that in para-cancerous and normal lung tissues and is positively associated with lymph node metastasis and MVD.
Hong-Zheng Zhu,Gang Wang,Hong-Liang Wei,Hui-Juan Chu,Jing Zhu 한국고분자학회 2016 Macromolecular Research Vol.24 No.9
Herein, a metal-free 1,3-dipolar cycloaddition click reaction was used to prepare hydrogels. First, copolymer of N,N-dimethylacrylamide and 2-hydroxyethyl methacrylate was synthesized via free radical copolymerization with an initiator of 2,2'-azobisisobutyronitrile and a solution of 1,4-dioxane. Second, maleimide-functionalized polymer was obtained by a coupling reaction of the above synthesized copolymer and N-maleoyl alanine with a dehydrating agent of N,N'-dicyclohexylcarbodiimide. Similarly, azido-modified polymer was prepared by the reaction between azidoacetic acid and the as-prepared copolymer. Third, the hydrogels were obtained by the reaction of the azidomodified polymer and maleimide-functionalized copolymer without any initiator or catalyst. Gelation times of different conditions were measured by a cuvette inversion method. The samples of different steps were analysized by means of FTIR, NMR, SEM, etc. The swelling behaviour of the gels was investigated via a general gravimetric method. Finally, release mechanism was explored with a model drug molecule of 5-fluorouracil. It was found temperature, concentration and solvent had an impact on the gelation time. And the swelling behavior and drug-controlled release profiles of the hydrogels were relevant to the concentration of polymers used for the hydrogels.
Outage Constrained Robust Beamforming for Secure Broadcasting Systems With Energy Harvesting
Zhu, Zhengyu,Chu, Zheng,Wang, Zhongyong,Lee, Inkyu IEEE 2016 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.15 No.11
<P>In this paper, we investigate simultaneous wireless information and power transfer systems for multiuser multiple-input single-output secure broadcasting channels. Considering imperfect channel state information, we introduce a robust secure beamforming design, where the transmit power is minimized subject to the secrecy rate outage probability constraint for legitimate users and the harvested energy outage probability constraint for energy harvesting receivers. The original problem is non-convex due to the presence of the probabilistic constraints. With the aid of Bernstein-type inequalities, we transform the outage constraints into the deterministic forms. Based on a successive convex approximation (SCA) method, we propose a low-complexity approach, which reformulates the original problem as a second-order cone programming problem. Also, we prove the convergence of the SCA-based iterative algorithm. Simulation shows that the proposed scheme outperforms the conventional method with lower complexity.</P>
Zhu, Zhengyu,Wang, Zhongyong,Lee, Kyoung-Jae,Chu, Zheng,Lee, Inkyu The Korea Institute of Information and Commucation 2016 Journal of communications and networks Vol.18 No.2
In this paper, we address a new robust optimization problem in a multiuser multiple-input single-output broadcasting system with simultaneous wireless information and power transmission, where a multi-antenna base station (BS) sends energy and information simultaneously to multiple users equipped with a single antenna. Assuming that perfect channel-state information (CSI) for all channels is not available at the BS, the uncertainty of the CSI is modeled by an Euclidean ball-shaped uncertainty set. To optimally design transmit beamforming weights and receive power splitting, an average total transmit power minimization problem is investigated subject to the individual harvested power constraint and the received signal-to-interference-plus-noise ratio constraint at each user. Due to the channel uncertainty, the original problem becomes a homogeneous quadratically constrained quadratic problem, which is NP-hard. The original design problem is reformulated to a relaxed semidefinite program, and then two different approaches based on convex programming are proposed, which can be solved efficiently by the interior point algorithm. Numerical results are provided to validate the robustness of the proposed algorithms.
Zhu, Zhengyu,Huang, Sai,Chu, Zheng,Zhou, Fuhui,Zhang, Di,Lee, Inkyu IEEE 2019 IEEE systems journal Vol.13 No.1
<P>In this paper, we investigate a multiuser distributed antenna system with simultaneous wireless information and power transmission under the assumption of imperfect channel state information (CSI). In this system, a distributed antenna port with multiple antennas supports a set of mobile stations that can decode information and harvest energy simultaneously via a power splitter. To design robust transmit beamforming vectors and the power splitting factors in the presence of CSI errors, we maximize the average worst-case signal-to-interference-plus-noise ratio (SINR) while achieving an individual energy harvesting constraint for each mobile station. First, we develop an efficient algorithm to convert the max–min SINR problem to a set of “dual” min–max power balancing problems. Then, motivated by the penalty function method, an iterative algorithm based on semidefinite programming is proposed to achieve a local optimal rank-one solution. Also, to reduce the computational complexity, we present another iterative scheme based on the Lagrangian method and the successive convex approximation technique to yield a suboptimal solution. Simulation results are shown to validate the robustness and effectiveness of the proposed algorithms.</P>
An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae
Chu, De-Jie,Guo, Shui-Gen,Pan, Chun-Feng,Wang, Jing,Du, Yong,Lu, Xu-Feng,Yu, Zhu-Yuan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Objective: To assess induction effects of Chlamydia pneumoniae (Cpn) on lung cancer in rats. Methods: A lung cancer animal model was developed through repeated intratracheal injection of Cpn (TW-183) into the lungs of rats, with or without exposure to benzo(a)pyrene (Bp). Cpn antibodies (Cpn-IgA, -IgG, and -IgM) in serum were measured by microimmunofluorescence. Cpn-DNA or Cpn-Ag of rat lung cancer was detected through polymerase chain reaction or enzyme-linked immunosorbent assay. Results: The prevalence of Cpn infection was 72.9% (35/48) in the Cpn group and 76.7% (33/43) in the Cpn plus benzo(a)pyrene (Bp) group, with incidences of lung carcinomas in the two groups of 14.6% (7/48) and 44.2% (19/43), respectively (P-values 0.001 and <0.000 compared with normal controls). Conclusions: A rat model of lung carcinoma induced by Cpn infection was successfully established in the laboratory for future studies on the treatment, prevention, and mechanisms of the disease.
Secure Beamforming Designs for Secrecy MIMO SWIPT Systems
Zhu, Zhengyu,Chu, Zheng,Zhou, Fuhui,Niu, Hehao,Wang, Zhongyong,Lee, Inkyu IEEE 2018 IEEE wireless communications letters Vol.7 No.3
<P>In this letter, secure beamforming designs are investigated in a multiple-input multiple-output secrecy channels with simultaneous wireless information and power transfer. In order to achieve fairness among different multiple energy harvesting receivers, the minimum harvested energy is maximized under the secrecy rate requirements. In particular, in order to reduce the computational complexity of the semidefinite programming problem, a successive convex approximation (SCA) iterative algorithm is proposed in the perfect channel state information (CSI) case to obtain a near-optimal rank-one solution. Moreover, the original problem is extended to the imperfect CSI case by incorporating a norm-bounded error model, where an SCA-based iterative algorithm is also proposed. Simulation results reveal that the SCA-based iterative algorithm achieves the same performance as the semidefinite relaxation method with reduced complexity.</P>