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Hot-Stamping Die-Cooling System for Vehicle Door Beams
Zhong-de Shan,Yong-sheng Ye,Mi-lan Zhang,Bao-yu Wang 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.
The need for lightweight automobiles has promoted the rapid development of hot stamping. The cooling system of the hotstamping die determines the performance of hot-stamped workpieces. By establishing a simplified hot-stamping model, we determined that the temperature–time curve of a workpiece is an exponential function. Our research results showed that the depth from the die surface to the cooling pipes has the biggest impact on the cooling rate and uniformity of the workpiece; the correct depth must be ensured to obtain a uniform quenching rate. By studying the cooling buffer flumes, we discovered that the water flow in the pipes becomes more uniform with increasing flume width. With an increase in the flume height, the water flow uniformity in the pipes first increased, and then decreased. In addition, augmenting the pipe diameter near the inlet improved the water flow uniformity in the pipes.
De-Jun Cheng,Jie Zhang,Zhong-Tai Hu,Sheng-Hao Xu,Xi-Feng Fang 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.10
This paper aims to propose a digital twin-driven (DTD) approach that consists of the machining data (MD) in twin data (TD), design of MD acquisition methodology, construction of intelligent algorithm, real-virtual data interaction analysis and fusion technology, which improvs the predictability and management of on-line quality control of marine diesel engine (MDE) critical parts. Firstly, this paper introduces the theoretical framework of DTD on-line quality control in machining process. Secondly, we construct the process of DTD on-line quality control and introduce the digital twin model of on-line quality control based on TD-driven; the operation of data-driven quality on-line control based on digital twin including description and modeling of MD; acquisition of MD based on digital twin; TD-driven on-line tool life prediction and data fusion on-line machining parameters optimization methods. Finally, a case study is applied to validate the accuracy and availability of the DTD approach. The proposed approach provides a new way for the on-line quality control of MDE critical parts in machining process.
Zhong-Ze Han,Hong-De Xu,Kwang-Ho Kim,Tae-Hwan Ahn,Jin-Sook Bae,Ji-Young Lee,Ki-Hyun Gil,Joo-Young Lee,Su-Jung Woo,Hyun-Jung Yoo,Hyun-Kul Lee,Kap-Ho Kim,Chan-Koo Park,Hu-Song Zhang,Si-Whan Song 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.2
The purpose of this paper is to provide reference data related to the body weight, food & water consumptions, urinalysis, hematology and serum biochemistry parameters and absolute & relative organ weights obtained from control Sprague-Dawley rats, used in the 4-week and 13-week repeated-dose toxicity studies conducted in our laboratory between 2005 and 2008. The mean, standard deviation, minimum and maximum range values for hematology and serum biochemistry parameters, data of absolute & relative organ weights, and the difference between sexes and study duration of week 4 versus 13 week are presented. The studies were conducted according to “the standards of Toxicity Study for Medicinal Products” (2005) and The KFDA Notification No. 2000-63 ‘Good Laboratory Practice (GLP)’ (2000) issued by KFDA. These data could be used as reference material of Sprague-Dawley rats by conducting the studies to evaluate the toxicological profile of pre-clinical toxicity studies.
Chlorogenic Acid-Enriched Extract of Ilex kudingcha C.J. Tseng Inhibits Angiogenesis in Zebrafish
Tao Zhong,Linghua Piao,김현정,Xian De Liu,Shengnan Jiang,Guomin Liu 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.12
Kudingcha is a particularly bitter tasting tea that has been widely used in China to eliminate fever and itching eyes, and to clear blood toxins. Kudingcha is considered of value for its potential anticancer effects that are attributed to the presence of characteristic bioactive ingredients. The chlorogenic acid (CGA) derivatives 3-0-caffeoylquinic acid, 5-0-caffeoylquinic acid, 3,5-0-dicaffeoylquinic acid, and 4,5-0-dicaffeoylquinic acid were separated from Ilex kudingcha C.J. Tseng extract by high-performance liquid chromatography (HPLC)–photodiode array detector (PDA) and HPLC-nuclear magnetic resonance (NMR). In Tg(flk1:EGFP) zebrafish embryos at 52 hours postfertilization (hpf), angiogenesis was significantly inhibited by kudingcha extract (KDCE) at concentrations of 400 and 500 μg/mL and CGA also showed significant inhibition in embryos treated with 80, 100, and 130 μg/mL. Endothelial cell apoptosis showed a dose-dependent increase in response to KDCE and CGA. CGA derivatives from KDCE could have potential as anticancer agents against tumor angiogenesis.