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ceRNA network of lncRNA MIR210HG/miR-377-3p/LMX1A in malignant proliferation of glioma cells
Yu Zhikuan,Che Ningwei,He Yeting,Zhang Bo 한국유전학회 2022 Genes & Genomics Vol.44 No.12
Background: Glioma represents the most heterogeneous and malignant form of brain tumor with a poor prognosis. The long non-coding RNA (LncRNA)-mediated competing endogenous RNA (ceRNA) network plays a regulatory role in cancer progression. Objectives: The present study was conducted to expound on the role of lncRNA MIR210 host gene (MIR210HG)-mediated ceRNA mechanism in the malignant proliferation of glioma cells and provide a novel theoretical basis for the treatment of glioma. Methods: Expression levels of lncRNA MIR210HG, microRNA (miR)-377-3p, and LIM homeobox transcription factor 1 alpha (LMX1A) in glioma tissues and cells were determined by reverse-transcription quantitative polymerase chain reaction. Then, cell proliferation was assessed by cell counting kit-8 and colony formation assays. After that, the subcellular localization of lncRNA MIR210HG was analyzed by subcellular fractionation assay and the bindings of miR-377-3p to lncRNA MIR210HG and LMX1A were analyzed by the dual-luciferase assay. Glioma cells were transfected with si-MIR210HG, miR-377-3p inhibitor, or overexpressed-LMX1A vectors to evaluate their effects on the malignant proliferation of glioma cells. Results: LncRNA MIR210HG was elevated in glioma tissues and cells and inhibition of lncRNA MIR210HG reduced the proliferation potential of glioma cells. LncRNA MIR210HG targeted and inhibited miR-377-3p and miR-377-3p targeted and inhibited LMX1A transcription. miR-377-3p downregulation or LMX1A overexpression reversed the inhibition of silencing lncRNA MIR210HG on glioma cell proliferation. Conclusion: LncRNA MIR210HG was upregulated in glioma tissues and cells and inhibition of lncRNA MIR210HG suppressed glioma cell proliferation through promoting miR-377-3p and repressing LMX1A.
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Effects of metal-molecule interface conformations on the electron transport of single molecule
Ping Bai,Er Ping Li,Chee Ching Chong,Zhikuan Chen 한국물리학회 2006 Current Applied Physics Vol.6 No.3
The electron transport eects of molecule locations on the metal interface are investigated through metalmoleculemetal systemsusing the rst principles method, based on density functional theory with norm conserving non-local pseudopotentials and non-equilib-rium Green’s functions. Three kinds of moleculemetal interface conformations are studied. These include locating the molecule on thetop, at the hollow site and on the bridge of metal surface atoms. AumoleculeAu open systems are constructed and numerically exam-sion functions of constructed systems are calculated and analyzed. Simulated results show that the on-atom contact exhibits the bestmoleculemetal coupling when an external bias lower than 1.4 V is applied. The bridge contact has a similar coupling as the hollow con-tact with a small dierence at larger external bias. This may partially explain why experimental results have poor repeatability.
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