Angelica sinensis Supercritical Fluid CO2 Extract Attenuates D-Galactose-Induced Liver and Kidney Impairment in Mice by Suppressing Oxidative Stress and Inflammation

Zhi-Zhun Mo,Zhi-Xiu Lin,ZiRen Su,Lin Zheng,Hui-Lin Li,JianHui Xie,Yan-Fang Xian,Tie-Gang Yi,Shui-Qing Huang,Jian-Ping Chen 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.9

Angelica sinensis (AS, Danggui in Chinese) is an important herbal component of various traditional formulae for the management of asthenia and its tonic effects. Although AS has been shown to ameliorate cognitive damage and nerve toxicity in D-galactose (D-gal)-elicited senescent mice brain, its effects on liver and kidney injury have not yet been explored. In this work, mice were subjected to hypodermic injection with D-gal (200 mg/kg) and orally gavaged with AS (20, 40, or 80 mg/kg) once a day for 8 successive weeks. Results revealed that AS significantly improved liver and kidney function as assessed by organ index and functional parameters. In addition, AS pretreatment effectively ameliorated the histological deterioration. AS attenuated the MDA level and markedly enhanced the activities and gene expressions of antioxidative enzymes, namely Cu, Zn-SOD, CAT, and GPx. Furthermore, AS markedly inhibited the D-gal-mediated increment of expressions of inflammatory cytokines iNOS, COX-2, IκBα, p-IκBα, and p65 and promoted the IκBα expression level in both hepatic and renal tissues. In sum, AS pretreatment could effectively guard the liver and kidney of mice from D-gal-induced injury, and the underlying mechanism was deemed to be intimately related to attenuating oxidative response and inflammatory stress.

중국 수묵화를 활용한 월분패 치파오의 패션디자인 연구

니모쯔 ( Mo Zhi Ni ),서승희 ( Seung Hee Suh ) 한국기초조형학회 2014 기초조형학연구 Vol.15 No.3

본 연구는 1930년대 월분패에 나타난 치파오의 디자인분석과 중국의 수묵화에서 보여 지는 여백, 농담의 특징을 부가적으로 활용하여, 현대적 감각에 맞는 치파오 패션디자인 작품제시를 연구 목적으로 하였다. 중국의 문호개방으로 인해 근대 서양의 광고형식이 중국에 유입되기 시작하여 월분패가 가장 번성하였던 1930년대를 연구범위로 제한하였으며, 수집한 213장의 월분패를 대상으로 분석하였다. 이를 통해 1930년대 월분패 속에 나타난 치파오의 형태를 디자인 구성요소 별로 분석하고 중국 수묵화에 대한 고찰을 토대로 하여, 치파오의 대표적인 디자인 구성요소인 매듭단추, 옆트임, 바이어스 트리밍을 활용한 디자인, 각각 2점씩 총 6점을 작품 제작하여 제시하였다. 즉, 월분패에 나타난 치파오 분석을 통한 치파오의 독특한 전통적 디자인 구성요소와, 수묵화의 동양적인 특성을 현대적 디자인에 응용하였다. 본 연구는 중국전통의 복식과 예술을 결합한 새로운 현대 패션디자인으로 제작함으로써, 전통문화요소를 현대적으로 발전 활성화시킬 수 있는 가능성을 제시하고자 하는 데 연구의 의의가 있다. The purpose of this study was to produce the fashion design onto which a traditional characteristic was grafted and which was in harmony with a modern style, by examining the design of Qipao, presented in the Yuefenpai (unique Chinese calendar) in the 1930s, and using such characteristics of Chinese ink-and-wash painting as blank and color depth. This study only dealt with the Yuefenpai in the 1930s, since with the open-door policy of China, Western civilization and its modern styles of advertisement had been flooding into China at that time and therefore the distribution of Yuefenpai came to the climax. In this regard, this study collected and analyzed 213 Yuefenpais in the 1930s, based on the results of analysis on the form of Qipaos, presented in Yuefenpais in the 1930s. By its design components, together with the analysis on Chinese ink-and-wash paintings, six modern fashion design works were produced, focusing on such typical design elements as knot buttons, side-opening and bias trimming (two works per element). The significance of this study seems to be in that as it applied the unique and traditional elements of Qipaos and the Oriental characteristics of ink-and-wash paintings to the modern design, based on the examination on Qipaos in Yuefenpais, namely by working out of modern fashion design works that combining Chinese traditional form of costumes and arts, it presented the potential of developing and activating traditional cultural elements in the modern design works.

Spin-resolved photoemission study of epitaxially grown MoSe₂ and WSe₂ thin films

Mo, Sung-Kwan,Hwang, Choongyu,Zhang, Yi,Fanciulli, Mauro,Muff, Stefan,Hugo Dil, J,Shen, Zhi-Xun,Hussain, Zahid IOP 2016 Journal of Physics, Condensed Matter Vol.28 No.45

<P>Few-layer thick MoSe<SUB>2</SUB> and WSe<SUB>2</SUB> possess non-trivial spin textures with sizable spin splitting due to the inversion symmetry breaking embedded in the crystal structure and strong spin–orbit coupling. We report a spin-resolved photoemission study of MoSe<SUB>2</SUB> and WSe<SUB>2</SUB> thin film samples epitaxially grown on a bilayer graphene substrate. We only found spin polarization in the single- and trilayer samples—not in the bilayer sample—mostly along the out-of-plane direction of the sample surface. The measured spin polarization is found to be strongly dependent on the light polarization as well as the measurement geometry, which reveals intricate coupling between the spin and orbital degrees of freedom in this class of material.</P>

Associations of hypoxia inducible factor-1a gene polymorphisms with susceptibility to digestive tract cancers: a case–control study and meta-analysis

Zhi-Hai Ni,Xian-Jun Liang,Jing-Gang Mo,Yi Zhang,Jian-Hua Liang,Yu-Sha Yang,Yong Zhou,Zhao-Hua Li,Jian-Liang Zhang,Yin-Lu Ding,Peng Zhang,Jin-Qing Wang 한국유전학회 2015 Genes & Genomics Vol.37 No.11

We aim to investigate the correlations of hypoxia inducible factor-1a (HIF-1a) C1772T (rs11549465) and G1790A (rs11549467) gene polymorphisms with digestive tract cancers. A sum of 267 digestive tract cancers patients were hospitalized in Taizhou Central Hospital of Zhejiang Province as case group between December 2012 and December 2014. Additionally, 275 healthy people who had a physical examination in our hospital at the same time were selected as control group. Polymerase chain reaction-restriction fragment length polymorphism was utilized for detecting allele and genotype frequency of different locus in case and control group. Meta-analysis was performed using Comprehensive Metaanalysis 2.0 (Biostat Inc., Englewood, New Jersey, USA). Our result showed statistical significance only exists in family history of cancer between case and control group (P\0.05). Both C1772T (rs11549465) and G1790A (rs11549467) polymorphisms showed positive correlations with an increasing risk of digestive tract cancers. The frequencies of TT genotype of C1772T (rs11549465) and GA, AA genotypes of G1790A (rs11549467) polymorphisms in case group were evidently higher compared with the controls (all P\0.05). Besides, the comparison of allele and dominant models of HIF-1a C1772T (rs11549465) and G1790A (rs11549467) between two groups showed a significant difference (all P\0.05). Meta-analysis results further confirmed that the onset risk of digestive tract cancers may be improved under allele and dominant models of HIF-1a C1772T (rs11549465) and G1790A (rs11549467) (all P\0.05). Single nucleotide polymorphisms of HIF-1a C1772T (rs11549465) and G1790A (rs11549467) may play a role in development of digestive tract cancers.

Active Fault Tolerant Control Scheme for Satellite Attitude Systems: Multiple Actuator Faults Case

Zhi-Feng Gao,Zepeng Zhou,Guoping Jiang,Mo-Shu Qian,Jin-Xing Lin 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.4

In this paper, an active fault tolerant control (FTC) design approach is proposed for the satellite attitude systems with exogenous disturbance and multiple actuator faults. Firstly, the nonlinear attitude system model of rigid satellite with multiple actuator faults is given. Next, an actuator fault diagnosis scheme, including a fault detection module and a fault estimation module, is given so as to detect the time of unknown actuator faults occurred and obtain their estimation values. Then, a terminal sliding mode-based fault tolerant attitude controller is designed using backstepping control technique, which guarantees that the closed-loop attitude systems of rigid satellite are asymptotically stable in the presence of multiple actuator faults. Numerical simulations illustrate the good performance of active FTC proposed in this study.

Incidence of Thymoma in Myasthenia Gravis: A Systematic Review

Zhi-Feng Mao,Xue-An Mo,Yong-Rong Lai,Maree L. Hackett 대한신경과학회 2012 Journal of Clinical Neurology Vol.8 No.3

Background and Purpose Myasthenia gravis (MG) is usually comorbid with thymoma. More accurate estimates of the incidence thymoma in MG will help inform patients and their physicians, facilitate health policy discussions, provide etiologic clues, and optimize the management of MG. Methods We conducted a systematic review search of relevant English-language studies published between 1960 and 2012 using MEDLINE and Embase. We identified additional studies by reviewing the bibliographies of the retrieved articles and hand searched the main neurology journals. Only incidence studies and case series of unselected MG patients in which information about thymoma were included. Results Out of 2206 potentially relevant studies, 49 met the inclusion criteria. Although there was a considerable degree of heterogeneity, the pooled estimate of the incidence of thymoma in MG was 21% (95% confidence interval, 20-22%). The pooled incidence was significantly higher for surgery-based studies than for population- and hospital-based studies. A large proportion of the reported thymomas were noninvasive. Furthermore, thymoma appears to occur significantly more frequently among male MG patients and those older than 40 years at the onset of MG. Conclusions Thymoma is common in MG patients, but appears to be found more often in male MG patients and those older than 40 years at the onset of MG. Further research is needed to expand our understanding of these association conditions

Effects of Cu²⁺ on alkaline phosphatase from <i>Macrobrachium rosenbergii</i>

Wang, Zhi-Jiang,Ma, Wenming,Yang, Jun-Mo,Kang, Yani,Park, Yong-Doo Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.117 No.-

<P><B>Abstract</B></P> <P>To gain insight into the effect of Cu<SUP>2+</SUP> on the activity and structure of alkaline phosphatase (ALP) from <I>Macrobrachium rosenbergii</I>, the enzyme was purified using ammonium sulfate fractionation, Sephacryl S-200, and DEAE anion exchange chromatography. We studied Cu<SUP>2+</SUP>-mediated inhibition and aggregation of ALP, and found that Cu<SUP>2+</SUP> significantly inactivated ALP activity with an <I>IC</I> <SUB>50</SUB> of 1.47 ± 0.02 mM. We further revealed that Cu<SUP>2+</SUP> reversibly inhibited ALP in a mixed-type manner with <I>K</I> <SUB>i</SUB> = 0.41 ± 0.02 mM. Time-interval kinetics showed that the inhibition followed first-order reaction kinetics. This process was associated with conformational changes and significant transient free-energy change. Spectrofluorometry results showed that Cu<SUP>2+</SUP> induced ALP tertiary structural changes, including the exposure of hydrophobic surfaces that directly induced ALP aggregation. The results provide new information regarding ALP from <I>M. rosenbergii</I>.</P>

INVESTIGATION OF OCCUPANT LOWER EXTREMITY INJURES UNDER VARIOUS OVERLAP FRONTAL CRASHES

Fuhao Mo,Shuyong Duan,Xiaoqing Jiang,Sen Xiao,Zhi Xiao,Wei Shi,Kai Wei 한국자동차공학회 2018 International journal of automotive technology Vol.19 No.2

Objective: With widely usage of restraint system, fatal injuries to occupants have been largely limited while non-fatal lower extremity injuries have not been effectively improved. The present study aims to investigate occupant lower extremity injuries under realistic impact environments. Methods: A biofidelic lower extremity model, a dummy model and a car cab model were combined to set up a realistic impact environment. Three typical frontal impact groups were simulated. Occupant global lower kinematics, long bone axial force and bending moment were presented to in-depth investigate lower extremity injury mechanism and tolerance. Results: Various overlap frontal impacts cause totally different lower extremity kinematics in the combination of structural invasion and restraint system effects. The femur fracture occurred at a small axial force of 7.57 kN combing a substantial bending moment peak of 172 Nm. Ankle joint injuries were found in 100 % and 25 % overlap impacts that present large tibial axial force and joint rotation angle. Conclusions: Overall results indicate that a coupling threshold of femur axial force and bending moment is of rationality to predict global femur fracture. The ankle joint injury occurrence is significantly related to the coupling effects of tibia axial force and excessive self-kinematics.

Proteomic analyses for profiling regulated proteins/enzymes by <i>Fucus vesiculosus</i> fucoidan in B16 melanoma cells: A combination of enzyme kinetics functional study

Wang, Zhi-Jiang,Zheng, Li,Yang, Jun-Mo,Kang, Yani,Park, Yong-Doo Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.112 No.-

<P><B>Abstract</B></P> <P>Fucoidans are complex sulfated polysaccharides that have a wide range of biological activities. Previously, we reported the various effects of <I>Fucus vesiculosus</I> fucoidan on tyrosinase and B16 melanoma cells. In this study, to identify fucoidan-targeted proteins in B16 melanoma cells, we performed a proteomics study and integrated enzyme kinetics. We detected 19 candidate proteins dysregulated by fucoidan treatment. Among the probed proteins, the enzyme kinetics of two candidate enzymes, namely lactate dehydrogenase (LDH) as an upregulated protein and superoxide dismutase (SOD) as a downregulated enzyme, were determined. The enzyme kinetics results showed that <I>Fucus vesiculosus</I> fucoidan significantly inhibited LDH catalytic function while it did not affect SOD activity even at a high dose, while only slightly decreased activity (up to 10%) at a low dose. Based on our previous and present observations, fucoidan could inhibit B16 melanoma cells growth via regulating proteins/enzymes expression levels such as LDH and SOD known as cell survival biomarkers. Interestingly, both expression level and enzyme catalytic activity of LDH were regulated by fucoidan, which could directly induce the apoptotic effect on B16 melanoma cells along with SOD downregulation. This study highlights how combining proteomics with enzyme kinetics can yield valuable insights into fucoidan targets.</P>

神性环保:云南少数民族生态哲学解析

?之?(Wu Zhi-qing),墨?金(Mo Jing-jin) 동아인문학회 2013 동아인문학 Vol.24 No.-

운남 소수민족의 원신종교 신앙은 “만물에 종교가 있다”는 것을 기조로 삼아 “천, 지, 인이 조화롭게 공존한다”는 소박한 사상을 내포하고 있고, “만약 인간이 자연을 존중하지 않으면 신령으로부터 벌을 받는다”는 일종의 환경보호의 정신을 확연히 나타내고 있다. 그 중의 신비로운 일면을 제거하면 많은 이념이 현재의 생태윤리와 자연스럽게 합치되고 있다. 본고는 이러한 사상에 대해 분석하였다.