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RISS 인기검색어
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- 저자 : Zhi Qiang Wu (검색결과 26 건)
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Wu, Qiang,Zhao, Yi-Bing,Sun, Zhi-Hua,Ni, Jing,Wu, Yu-Zhong,Shao, Heng-Hua,Qu, Jun-Wei,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Aim: To examine lymph nodes obtained after lipolysis and liposuction of subcutaneous fat of the inguinal region of female vulvar cancer patients to explore the feasibility of clinical application. Methods: The field of operation was on the basis of the range of the conventional resection of inguinal lymph nodes. We injected lipolysis liquid fanwise, started liposuction after 15-20 minutes; then the subcutaneous fatty tissue was sucked out clearly by suction tube. We selected the first puncture holes located on 2-3 cm part below anterior superior spine, the others respectively being located 3cm and 6cm below the first for puncturing into the skin, imbedding a trocar to intorduce $CO_2$ gas and the specular body, and excise the lymph nodes by ultrasonic scalpel. The surgical field chamber was set with negative pressure drainage and was pressured with a soft saline bag after surgery. Results: A lacuna emerged from subcutaneous of the inguinal region after lipolysis and liposuction, with a wide fascia easily exposed at the bottom where lymph nodes could be readily excised. The number of lymph nodes of ten patients excised within the inguinal region on each side was 4-18. The excised average number of lymph nodes was 11 when we had mature technology. Conclusion: Most of adipose tissue was removed after lipolysis and liposuction of subcutaneous tissue of inguinal region, so that the included lymph nodes were exposed and easy to excise by endoscope. This surgery avoided the large incision of regular surgery of inguinal region, the results indicating that this approach is feasible and safe for used as an alternative technology.
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( Zhi-qiang Ren ),( Yan Liu ),( Xiao-qiong Pei ),( Zhong-liu Wu ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.11
Ethyl (S)-3-hydroxy-3-(2-thienyl) propanoate ((S)-HEES) acts as a key chiral intermediate for the blockbuster antidepressant drug duloxetine, which can be achieved via the stereoselective bioreduction of ethyl 3-oxo-3-(2-thienyl) propanoate (KEES) that contains a 3-oxoacyl structure. The sequences of the short-chain dehydrogenase/reductases from Chryseobacterium sp. CA49 were analyzed, and the putative 3-oxoacyl-acyl-carrier-protein reductase, ChKRED12, was able to stereoselectively catalyze the NADPH-dependent reduction to produce (S)-HEES. The reductase activity of ChKRED12 towards other substrates with 3- oxoacyl structure were confirmed with excellent stereoselectivity (>99% enantiomeric excess) in most cases. When coupled with a cofactor recycling system using glucose dehydrogenase, the ChKRED12 was able to catalyze the complete conversion of 100 g/l KEES within 12 h, yielding the enantiopure product with >99% ee, showing a remarkable potential to produce (S)-HEES.
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Alternative accuracy for multiple ROC analysis
홍종선,Zhi Qiang Wu 한국데이터정보과학회 2014 한국데이터정보과학회지 Vol.25 No.6
The ROC analysis is considered for multiple class diagnosis. There exist many criteria to find optimal thresholds and measure the accuracy of diagnostic tests for k dimensional ROC analysis. In this paper, we proposed a diagnostic accuracy measure called the correct classification simple rate, which is defined as the summation of true rates for each classification distribution and expressed as a function of summation of sequential true rates for two consecutive distributions. This measure does not weight accuracy across categories by the category prevalence and is comparable across populations for multiple class diagnosis. It is found that this accuracy measure does not only have a relationship with Kolmogorov - Smirnov statistics, but also can be represented as a linear function of some optimal threshold criteria. With these facts, the suggested measure could be applied to test for comparing multiple distributions.
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Effects of enclosures on vegetation recovery and succession in Hulunbeier steppe, China
박기형,Zhi Qiang Qu,Qin Qin Wan,Guo Dong Ding,Bin Wu 한국산림과학회 2013 Forest Science And Technology Vol.9 No.1
Hulunbeier steppe is one of the four largest grasslands in China and is renowned for its excellent natural grassland conditions. However, its natural ecosystem has been continuously disrupted due to heavy land use, excessive stock-farming, and deforestation as human activities have expanded. Exclusion of human disturbance is one of the common measures used for ecological environment restoration in Chinese desert areas. This study aims to investigate whether the duration of enclosure affects vegetation recovery and succession processes. Plant distribution, coverage and biomass were measured and described in non-enclosure, 1-year, 5-year, and 10-year enclosure plots. Vegetation succession proceeded via three stages. In the first stage, annual plant communities, such as Agriophyllum squarrosum and Corispermum stauntonii, were dominant, while in the second stage renascent arboreal herbs, mainly Cleistogenes squarrosa and Artemisia frigid, predominantly occupied the vegetation community. In the third stage, transition vegetation such as Agropyron cristatum and C. squarrosa werepredominant. Relevant government authorities in the Hulunbeier region should educate the herders regarding the apposite management of enclosure and provide incentives for compliance. Future study design should focus on effective enclosure management including grazing rate control and plantation development in enclosure.
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Selective Removal of Al(III) from Rare Earth Solutions Using Peas-based Activated Carbon
Fu-Qiang An,Rui-Yan Wu,Zhi-Guo Yuan,Tuo-Ping Hu,Jian-Feng Gao 대한화학회 2017 대한화학회지 Vol.61 No.5
Efficiently removing Al(III) from rare earth is very significant because even trace amount of Al(III) can cause serious harm to the rare earth materials. In this paper, a nitrogen-containing activated carbon, AC-P700, was synthesized using peas as raw materials. The AC-P700 was characterized by surface area analyzer, FT-IR, and XPS methods. The adsorption and recognition properties of AC-P700 towards Al(III) were investigated, and the recognition mechanism was also analyzed. The BET special surface area of AC-P700 was 1277.1 m2·g−1, and the average pore diameter was 1.90 nm. The AC-P700 possesses strong adsorption affinity and excellent recognition selectivity towards Al(III). The adsorption capacity for Al(III) could reach to 0.53 mmol·g−1, and relative selectivity coefficients relative to La(III) and Ce(III) is 9.6 and 8.7, respectively. Besides, ACP700 possesses better regeneration ability and reusability.
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Selective Removal of Al(III) from Rare Earth Solutions Using Peas-based Activated Carbon
An, Fu-Qiang,Wu, Rui-Yan,Li, Min,Yuan, Zhi-Guo,Hu, Tuo-Ping,Gao, Jian-Feng Korean Chemical Society 2017 대한화학회지 Vol.61 No.5
Efficiently removing Al(III) from rare earth is very significant because even trace amount of Al(III) can cause serious harm to the rare earth materials. In this paper, a nitrogen-containing activated carbon, AC-P700, was synthesized using peas as raw materials. The AC-P700 was characterized by surface area analyzer, FT-IR, and XPS methods. The adsorption and recognition properties of AC-P700 towards Al(III) were investigated, and the recognition mechanism was also analyzed. The BET special surface area of AC-P700 was $1277.1m^2{\cdot}g^{-1}$, and the average pore diameter was 1.90 nm. The AC-P700 possesses strong adsorption affinity and excellent recognition selectivity towards Al(III). The adsorption capacity for Al(III) could reach to $0.53mmol{\cdot}g^{-1}$, and relative selectivity coefficients relative to La(III) and Ce(III) is 9.6 and 8.7, respectively. Besides, AC-P700 possesses better regeneration ability and reusability.
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Ni, Jing,Wu, Qiang,Sun, Zhi-Hua,Zhong, Jian,Cai, Yu,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11
Background: To investigate the inhibitory effect and the underlying mechanism of triptolide on cultured human endometrial carcinoma HEC-1B cells and corresponding xenograft. Materials and Methods: For in vitro studies, the inhibition effect of proliferation on HEC-1B cell by triptolide was determined by MTT assay; cell cycle and apoptosis of the triptolide-treated and untreated cells were detected by flow cytometry. For in vivo studies, a xenograft tumor model of human endometrial carcinoma was established using HEC-1B cells, then the tumor-bearing mice were treated with high, medium, and low-dose ($8{\mu}g$, $4{\mu}g$ and $2{\mu}g/day$) triptolide or cisplatin at $40{\mu}g/day$ or normal saline as control. The mice were treated for 10-15 days, during which body weight of the mice and volume of the xenograft were weighted. Then expression of Bcl-2 and vascular endothelial growth factor (VEGF) was analyzed by SABC immunohistochemistry. Results: Cell growth was significantly inhibited by triptolide as observed by an inverted phase contrast microscope; the results of MTT assay indicated that triptolide inhibits HEC-1B cell proliferation in a dose and time-dependent manner; flow cytometry showed that low concentration (5 ng/ml) of triptolide induces cell cycle arrest of HEC-1B cells mainly at S phase, while higher concentration (40 or 80 ng/ml) induced cell cycle arrest of HEC-1B cells mainly at G2/M phase, and apoptosis of the cells was also induced. High-dose triptolide showed a similar tumor-inhibitory effect as cisplatin (-50%); high-dose triptolide significantly inhibited Bcl-2 and VEGF expression in the xenograft model compared to normal saline control (P<0.05). Conclusions: triptolide inhibits HEC-1B cell growth both in vitro and in mouse xenograft model. Cell cycle of the tumor cells was arrested at S and G2/M phase, and the mechanism may involve induction of tumor cell apoptosis and inhibition of tumor angiogenesis.
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Alternative accuracy for multiple ROC analysis
Hong, Chong Sun,Wu, Zhi Qiang The Korean Data and Information Science Society 2014 한국데이터정보과학회지 Vol.25 No.6
The ROC analysis is considered for multiple class diagnosis. There exist many criteria to find optimal thresholds and measure the accuracy of diagnostic tests for k dimensional ROC analysis. In this paper, we proposed a diagnostic accuracy measure called the correct classification simple rate, which is defined as the summation of true rates for each classification distribution and expressed as a function of summation of sequential true rates for two consecutive distributions. This measure does not weight accuracy across categories by the category prevalence and is comparable across populations for multiple class diagnosis. It is found that this accuracy measure does not only have a relationship with Kolmogorov - Smirnov statistics, but also can be represented as a linear function of some optimal threshold criteria. With these facts, the suggested measure could be applied to test for comparing multiple distributions.
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Yan Zhou,Xin’an Wu,Guo-Qiang Zhang,Zhi Rao,Yang Yang,Qian Zhou,Hongyan Qin,Yuhui Wei 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.7
Venlafaxine (VLX) could be pumped out of the brain by P-glycoprotein (P-gp). Moreover, the expression of P-gp distributed in blood–brain barrier could be significantly induced by VLX. Thus, P-gp could be considered as the nature barrier for delivering of VLX to the brain. The aim of this study was to investigate whether the efflux function and increased expression of P-gp could be reversed by utilizing solid lipid nanoparticles (SLN). VLX solid lipid nanoparticles (VLX - SLN) were prepared and evaluated. Pharmacokinetics and brain distribution of VLX in different formulations were conducted after oral or intravenous administration. P-gp efflux function to VLX was evaluated by the brain uptake amount of VLX, while P-gp expression was investigated by Western blotting. Results indicated that the entrapment, mean size and zata potential of VLX - SLN was 74.9 ± 3.0 %, 186.3 ± 69.26 nm and -22.8 ± 7.78 mv, respectively. After vein injection of VLX formulations, the brain uptake amount of VLX from VLX - SLN was significantly higher than that of VLX solution, VLX solution with empty SLN (VLX? empty SLN) and VLX solution with Verapamil (VLX ? Ver), respectively. Furthermore, the protein mass of P-gp in VLX - SLN treated group was the lowest among all the investigated groups. These results indicated that SLN could overcome P-gp and achieve brain target by intravenous administration.
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