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Research on the development of venture capital and high-tech industry in China’s western regions
ZhengJun,Zhou Yunlan 한국경영교육학회 2011 한국경영교육학회 학술발표대회논문집 Vol.2011 No.12
One of the important aspect of China’s further implementing the western development under the new condition is paying more emphasis on ecological and environmental protection. Learning experience and lessons from the past economic development, we can get the conclusion that the technology progress is one of the powerful weapons to deal with environmental issues and development bottleneck. Using the data, this paper has analyzed the present situation and existing problem of the aspect of venture capital and high-tech industry development in China’s western regions, then put forward some ideas to solve the relevant issues and to promote better development of venture capital and high-tech industries in China’s western regions and take the sustainable development road from the aspect of increasing the state’s related efforts to support western region, increasing funding in the Science and technology, perfecting the multi-level capital market to improve the venture capital’s exiting mechanism and so on.
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Zheng Jun,Huang Ju,Zhang Liang,Wang Mengna,Xu Lihong,Dou Xiaoyun,Leng Xiaojing,Fang Mingxiao,Sun Yang,Wang Zhigang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Although programmed cell death protein 1 (PD-1)/ programmed cell death-ligand protein 1 (PD-L1) checkpoint blockade immunotherapy demonstrates great promise in cancer treatment, poor infiltration of T cells resulted from tumor immunosuppressive microenvironment (TIME) and insufficient accumulation of anti-PD-L1 (αPD-L1) in tumor sites diminish the immune response. Herein, we reported a drug-loaded microbubble delivery system to overcome these obstacles and enhance PD-L1 blockade immunotherapy.Docetaxel (DTX) and imiquimod (R837)-loaded microbubbles (RD@MBs) were synthesized via a typical rotary evaporation method combined with mechanical oscillation. The targeted release of drugs was achieved by using the directional "bursting" capability of ultrasound-targeted microbubble destruction (UTMD) technology. The antitumor immune response by RD@MBs combining αPD-L1 were evaluated on 4T1 and CT26 tumor models.The dying tumor cells induced by DTX release tumor-associated antigens (TAAs), together with R837, promoted the activation, proliferation and recruitment of T cells. Besides, UTMD technology and DTX enhanced the accumulation of αPD-L1 in tumor sites. Moreover, RD@MBs remolded TIME, including the polarization of M2-phenotype tumor-associated macrophages (TAMs) to M1-phenotype, and reduction of myeloid-derived suppressor cells (MDSCs). The RD@MBs + αPD-L1 synergistic therapy not only effectively inhibited the growth of primary tumors, but also significantly inhibited the mimic distant tumors as well as lung metastases.PD-L1 blockade immunotherapy was enhanced by RD@MBs delivery system.
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Zhengjun Mao,Xiaokang Wang,Ning An,Xiaojun Li,Rongyu Wei 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.10
The water disaster susceptible areas in loess multi-arch tunnels were studied. Taking Lishi multi-arch tunnel as an example, the tunnel is located in Luliang City, Shanxi Province, China, with a total length of 180 m. It is the first loess multi-arch tunnel in China. The groundwater recharge in the tunnel site is dominated by rainfall, and the surrounding rock of the tunnel is unsaturated. Considering the lateral recharge of groundwater, in this study, midas geo-technical analysis system was adopted to simulate the construction process of a middle pilot tunnel–bilateral pilot tunnel of a loess multi-arch tunnel, accounting for fluid-solid coupling. The variations in the surrounding rock stress and seepage fields of loess multi-arch tunnels during the construction process were studied. A water disaster susceptible area in a loess multi-arch tunnel was confirmed based on the catastrophe area of the displacement, stress, gross head, pore water pressure, and seepage velocity. The result show that the water disaster susceptible areas for loess multi-arch tunnels during the construction period mainly concentrated in the mid-partition, arch springs of the left and right tunnels, and the tunnel face.
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Biochemical Adaptation to the Freezing Environment - the Biology of Fish Antifreeze Proteins
Zhengjun Li,Qingsong Lin,Woon-Kai Low,Megan Miao,Choy L. Hew 한국해양과학기술원 2003 Ocean and Polar Research Vol.25 No.3s
Many organisms are known to survive in icy environments. These include both over wintering terrestrial insects and plants as well the marine fish inhabiting high latitudes. The adaptation of these organisms is both a fascinating and important topic in biology. Marine teleosts in particular, can encounter ice-laden seawater that is approximately 1oC colder than the colligative freezing point of their body fluids. These animals produce a unique group of proteins, the antifreeze proteins (AFPs) or antifreeze glycoproteins (AFGPs) that absorb the ice nuclei and prevent ice crystal growth. Presently, there are at least four different AFP types and one AFGP type that are isolated from a wide variety of fish. Despite their functional similarity, there is no apparent common protein homology or ice-binding motifs among these proteins, except that the surface-surface complementarity between the protein and ice are important for binding. The remarkable diversity of these proteins and their odd phylogenetic distribution would suggest that these proteins might have evolved recently in response to sea level glaciations just 1-2 million years ago in the northern hemisphere and 10-30 million years ago around Antarctica. Winter flounder, Pleuronectes americanus, has been used as a popular model to study the regulation of AFP gene expression. It has a built-in annual cycle of AFP expression controlled negatively by the growth hormone. The signal transduction pathways, transcription factors and promoter elements involved in this process have been studied in our laboratory and these studies will be presented.
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SOC ESTIMATION OF Li-ION BATTERY BASED ON IMPROVED EKF ALGORITHM
Zhengjun Huang,Yongshou Fang,Jianjun Xu 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.2
The state of charge (SOC) is one of the important performance indicators of battery, which provides an important basis for the management and control of Battery Management System (BMS). In view of the characteristics of lithium iron phosphate battery, considering the model accuracy and calculation amount, the equivalent circuit model of improved PNGV was selected. Based on that, an improved Extended Kalman Filter (EKF) algorithm was adopted to estimate the state of charge (SOC) of Li-ion battery, which covariance matrix was modified by the Levenberg-Marquardt method. At the end of this paper, the SOC estimation algorithm was verified by MATLAB simulations. The results show that compared with the standard EKF, the improved EKF has higher estimation accuracy and anti-interference ability, and has better convergence in the estimation process.
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Biochemical Adaptation to the Freezing Environment - the Biology of Fish Antifreeze Proteins
Li, Zhengjun,Li, n Qingsong,Low Woon-Kai,Miao Megan,Hew Choy L. Korea Institute of Ocean ScienceTechnology 2003 Ocean and Polar Research Vol.25 No.4
Many organisms are known to survive in icy environments. These include both over wintering terrestrial insects and plants as well the marine fish inhabiting high latitudes. The adaptation of these organisms is both a fascinating and important topic in biology. Marine teleosts in particular, can encounter ice-laden seawater that is approximately $1^{\circ}C$ colder than the colligative freezing point of their body fluids. These animals produce a unique group of proteins, the antifreeze proteins (AFPs) or antifreeze glycoproteins (AFGPs) that absorb the ice nuclei and prevent ice crystal growth. Presently, there are at least four different AFP types and one AFGP type that are isolated from a wide variety of fish. Despite their functional similarity, there is no apparent common protein homology or ice-binding motifs among these proteins, except that the surface-surface complementarity between the protein and ice are important for binding. The remarkable diversity of these proteins and their odd phylogenetic distribution would suggest that these proteins might have evolved recently in response to sea level glaciations just 1-2 million years ago in the northern hemisphere and 10-30 million years ago around Antarctica. Winter flounder, Pleuronectes americanus, has been used as a popular model to study the regulation of AFP gene expression. It has a built-in annual cycle of AFP expression controlled negatively by the growth hormone. The signal transduction pathways, transcription factors and promoter elements involved in this process have been studied in our laboratory and these studies will be presented.
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Differentiation of Streptococcus thermophilus Strains in Commercial Direct Vat Set Yoghurt Starter
Chengjie Ma,Zhengjun Wu,Zhengjun Chen,Zhaoping Du,Kejie Sun,Aimin Ma 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.4
Based on inhibition of acid production, 100individual colonies of Streptococcus thermophilus isolated from commercial Direct Vat Set yoghurt starter DVS-M were typed into 2 groups of sensitive and insensitive to phage ϕ001, which was isolated from the lysis culture of the turbidity test. The ratio between the sensitive and insensitive isolates in DVS-M was calculated at 3:2. Whole-cell protein profile (WCPP) and randomly amplified polymorphic DNA (RAPD) analysis showed that both WCPP and RAPD patterns between sensitive and insensitive isolates were distinct, whereas isolates with the same sensitivity or insensitivity shared common WCPP and RAPD patterns. It suggested that all the sensitive isolates belong to one S. thermophilus strain and all the insensitive isolates belong to another one. This study revealed that DVS-M yoghurt starter consists of 2 S. thermophilus strains with different phage sensitivity.
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Ying Huang,Zhengjun Cheng 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.10
Herein, we have reported the synthesis of boron-, sulfur-, and nitrogen-co-doped carbon dots (B/S/ N-CDs) by one-step hydrothermal method using D-(+)-maltose monohydrate, boracic acid, and thiocarbamide as the precursors. The prepared B/S/N-CDs possess good water dispersibility, excellent pH stabilities, and resistance to photobleaching. Furthermore, the transmission electron microscope image indicates that the B/S/N-CDs are homogeneously spherical and show good dispersion. Noticeably, the B/S/N-CDs show bright blue photoluminescence with a quantum yield of 8.9% in aqueous solution and can be used as a potent photoluminescent probe for selective and sensitive detection of sunset yellow (SY). Compared with other food colors, SY can dramatically quench the fluorescence of B/S/N-CDs. Meanwhile, the fluorescence intensity displays a good linear response with SY concentration in the range of 0–70 μM (R2 = 0.9980) and the detection limit is as low as 4.65 nM. The B/S/N-CDs can also be applied for the detection of SY in mineral water and business drink with satisfactory recovery. Our study has demonstrated that the B/S/N-CDs may have wide application values inmedical detection, environmental monitoring, and related researches.
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