Thermal and mechanical properties of poly(latic acid) reinforced with silanized basalt scales

Shan-Shan Yao,Ming-Zhan Gao,Zhao-Yang Feng,Fan-Long Jin,박수진 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.7

Biodegradable poly(lactic acid) (PLA)-based composites were prepared using PLA and basalt scale (BS) viaa solution-blending method. BS surfaces were treated using a silane coupling agent, and their surface properties werecharacterized by high-resolution scanning electron microscopy, energy-dispersive X-ray spectrometry, and X-ray photoelectronspectrometry. Moreover, the influence of BS content on the thermal properties, flexural properties, impactstrength, and morphology of the PLA/silane-coupling-agent-treated BS (KH-BS) composites was analyzed. The thermalstability of the composites significantly increased due to the addition of KH-BS. Impact strength tests showed thatthe impact strength of the PLA/KH-BS composite with 4 wt% KH-BS was 3.14 kJ/m2, which is 51% higher than that ofpristine PLA (2.07 kJ/m2). The analysis of the fracture surfaces of the composites after the impact strength tests revealeda rough morphology with numerous river-like micro-cracks. The study results demonstrate that the addition of KH-BSsignificantly improves the thermal stability and impact strength of PLA/KH-BS composites.

료저지구구석기문화연구회고여전망

신점산(Xin Zhan Shan),고옥재(Gu Yu Cai) 충북대학교 중원문화연구소 1996 동북아 구석기문화 Vol.- No.-

Significant Differences in the Clinicopathological Characteristics and Survival of Gastric Cancer Patients from Two Cancer Centers in China and Korea

Zhan Long Shen,송교영,Ying Jiang Ye,Qi Wei Xie,Bin Liang,Kewei Jiang,박조현,Shan Wang 대한위암학회 2015 Journal of gastric cancer Vol.15 No.1

Purpose: To compare the clinicopathological data and long-term survival of gastric cancer patients in China and Korea. Materials and Methods: Patients who had undergone gastrectomy for gastric cancer between 1998 and 2009 in 2 high-volume institutions in both China (n=1,637) and Korea (n=2,231) were retrospectively evaluated. Clinicopathological variables, overall survival (OS), progression-free survival (PFS), and surgery-related complications were assessed for all patients and compared between the 2 institutions. Results: Chinese patients included in the study were significantly older and had a significantly lower body mass index (BMI) than the Korean patients. Esophagogastric junction tumors were more frequent in Chinese patients. However, the number of patients with stage I gastric cancer, the number of harvested lymph nodes, and the number of total gastrectomies were significantly higher in the Korean population. Korean patients also presented with fewer undifferentiated tumors than Chinese patients. Furthermore, Korean patients had prolonged OS and PFS for stage III cancers only. BMI, tumor-node-metastasis (TNM) stage, tumor invasion, number of positive lymph nodes, and distant metastases were all independent factors affecting OS and PFS. Conclusions: Although China and Korea are neighboring Asian countries, the clinicopathological characteristics of Chinese patients are significantly different from those of Korean patients. Korean gastric cancer patients had longer OS and PFS than Chinese patients. Influencing factors included TNM stage, tumor invasion, and lymph node metastasis.

Significant Differences in the Clinicopathological Characteristics and Survival of Gastric Cancer Patients from Two Cancer Centers in China and Korea

Shen, Zhan Long,Song, Kyo Young,Ye, Ying Jiang,Xie, Qi Wei,Liang, Bin,Jiang, Kewei,Park, Cho Hyun,Wang, Shan The Korean Gastric Cancer Association 2015 Journal of gastric cancer Vol.15 No.1

Purpose: To compare the clinicopathological data and long-term survival of gastric cancer patients in China and Korea. Materials and Methods: Patients who had undergone gastrectomy for gastric cancer between 1998 and 2009 in 2 high-volume institutions in both China (n=1,637) and Korea (n=2,231) were retrospectively evaluated. Clinicopathological variables, overall survival (OS), progression-free survival (PFS), and surgery-related complications were assessed for all patients and compared between the 2 institutions. Results: Chinese patients included in the study were significantly older and had a significantly lower body mass index (BMI) than the Korean patients. Esophagogastric junction tumors were more frequent in Chinese patients. However, the number of patients with stage I gastric cancer, the number of harvested lymph nodes, and the number of total gastrectomies were significantly higher in the Korean population. Korean patients also presented with fewer undifferentiated tumors than Chinese patients. Furthermore, Korean patients had prolonged OS and PFS for stage III cancers only. BMI, tumor-node-metastasis (TNM) stage, tumor invasion, number of positive lymph nodes, and distant metastases were all independent factors affecting OS and PFS. Conclusions: Although China and Korea are neighboring Asian countries, the clinicopathological characteristics of Chinese patients are significantly different from those of Korean patients. Korean gastric cancer patients had longer OS and PFS than Chinese patients. Influencing factors included TNM stage, tumor invasion, and lymph node metastasis.

Tuning hydrophobic surface with vertically polymerised microflake structures fabricated using heptadecafluoro-1,1,2,2-tetrahydrodecyltrichlorosilane

박진영,박병락,Li Zhan,Weixiao Du,Baozhen Shan,Guojie Liu,황운봉 한국물리학회 2019 Current Applied Physics Vol.19 No.4

This work presents a facile fabrication method for vertical polymerised structures with a tuned superhydrophobic surface on an aluminium alloy. This method includes vertically polymerising heptadecafluoro- 1,1,2,2-tetra-hydrodecyltrichlorosilane (HDFS), which is used for self-assembled monolayer (SAM) coatings, wherein vertical polymerisation is normally considered a process defect. For fabricating the base structure, aluminium hydroxide was generated to form a nanostructure. HDFS was coated as an SAM and microflake fabrication was carried out on this surface for various lengths of time. Microflakes were fabricated by vertical polymerisation of HDFS through this process. Samples coated for 10–30 min showed the water contact angle (θC) of>168.3° and the lowest water sliding angle (θS) of<11.8°. After 30 min, the water droplet clung to the microstructure that increased in size beyond 1 μm, thereby increasing of θS. This micro/nano dual-scale-flake surface was achieved without any hazardous etching processes and can be facilely applied in various industrial fields that require superhydrophobic surfaces.

Improvement of hEGF Production with Enhanced Cell Division Ability Using Dissolved Oxygen Responses to Pulse Addition of Tryptone

Zhi-Yong Zheng,Xiaobei Zhan,Chi Chung Lin,Shan-Jing Yao 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.1

Tryptone has multiple and complex effects on cell physiology and process performance in pulse fed-batch cultivation of recombinant Escherichia coli. By applying feedback control of dissolved oxygen signal responding to pulse in the feed rate, the production of acetate was avoided and the optimization of production of recombinant human epidermal growth factor (hEGF) was successfully achieved. With the addition of an optimum amount of tryptone along with glucose in the pulse fed-batch cultivation of E. coli, the ability of the cell to divide and the stability of the plasmid within the bacteria were improved. Consequently, segregation of the cells into a viable but non-culturable physiological state was alleviated. Addition of tryptone also enhanced cell respiration before and after hEGF expression and thus further benefited the production of recombinant hEGF. Excessive addition of tryptone resulted in low sensitivity of the oscillation of dissolved oxygen signal and poor operability of pulse fed-batch cultivation as this led to an accumulation of acetate, which weakened the dissolved oxygen signal responses. Consequently, the production of recombinant protein was considerably reduced. By combining the process performance and the positive effect of complex media pulse addition on bacterial metabolism, the optimal production conditions of hEGF were successfully determined. A high cell density of 91 g/L dry cell weight was obtained under these optimal production conditions. Furthermore, a high level of 0.24 g/L hEGF was attained leading to a 32.6% increase in product yield as compared to the controls.

Study on the Social Adaptation of Chinese Children with Down Syndrome

Yan-xia Wang,Shan-shan Mao,Chun-hong Xie,Yu-feng Qin,Zhi-wei Zhu,Jian-ying Zhan,Jie Shao,Rong Li,Zheng-yan Zhao 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.3

Immune and Anti-oxidant Functions of Ethanol Extracts of Scutellaria baicalensis Georgi in Mice Bearing U14 Cervical Cancers

Peng, Yong,Guo, Cong-Shan,Li, Pan-Xia,Fu, Zhan-Zhao,Gao, Li-Ming,Di, Ya,Ju, Ya-Kun,Tian, Ru,Xue, Jia-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10

Background: The objective was to study the effect of Scutellaria baicalensis Georgi ethanol extracts (SBGE) on immune and anti-oxidant function in U14 tumor-bearing mice. Materials and Methods: U14 tumor-bearing mice were randomly divided into eight groups: a control group, a cyclophosphamide (CTX) group, three dose groups of SBGEI (high, medium, low), and three dose groups of SBGEII (high, medium, low). After two weeks, the thymus and spleen weight indices of mice bearing U14 cervical cancer were calculated. Enzyme linked immunosorbent assays (ELISA) was used to determine the levels of serum IL-2, TNF-${\alpha}$, IL-8, and PCNA. MDA activity and SOD activity in plasma were measured with detection kits. Results: In the SBGE groups, thymus weight and spleen weight indices of U14 tumor-bearing mice were significantly higher than in the control group or CTX group (p<0.05). Compared to control group, the levels of serum IL-2 and TNF-${\alpha}$ in U14 tumor-bearing mice increased significantly, whereas the contents of serum IL-8 and PCNA decreased (p<0.05). The activity of SOD increased with the growing dose of SBGE, while the activity of MDA decreased significantly in the highe-rdose groups of SBGE. Conclusions: These findings suggested that SBGE, especially at high dose, 1000 mg/kg, showed significant immune and anti-oxidant effects infU14 tumor-bearing mice, which might be the mechanisms of SBGE inhibition of tumor growth.

An improved Maxwell creep model for salt rock

Wang, Jun-Bao,Liu, Xin-Rong,Song, Zhan-Ping,Shao, Zhu-Shan Techno-Press 2015 Geomechanics & engineering Vol.9 No.4

The creep property of salt rock significantly influences the long-term stability of the salt rock underground storage. Triaxial creep tests were performed to investigate the creep behavior of salt rock. The test results indicate that the creep of salt rock has a nonlinear characteristic, which is related to stress level and creep time. The higher the stress level, the longer the creep time, the more obvious the nonlinear characteristic will be. The elastic modulus of salt rock decreases with the prolonged creep time, which shows that the creep damage is produced for the gradual expansion of internal cracks, defects, etc., causing degradation of mechanical properties; meanwhile, the creep rate of salt rock also decreases with the prolonged creep time in the primary creep stage, which indicates that the mechanical properties of salt rock are hardened and strengthened. That is to say, damage and hardening exist simultaneously during the creep of salt rock. Both the damage effect and the hardening effect are considered, an improved Maxwell creep model is proposed by connecting an elastic body softened over time with a viscosity body hardened over time in series, and the creep equation of which is deduced. Creep test data of salt rock are used to evaluate the reasonability and applicability of the improved Maxwell model. The fitting curves are in excellent agreement with the creep test data, and compared with the classical Burgers model, the improved Maxwell model is able to precisely predict the long-term creep deformation of salt rock, illustrating our model can perfectly describe the creep property of salt rock.

Sorafenib Continuation after First Disease Progression Could Reduce Disease Flares and Provide Survival Benefits in Patients with Hepatocellular Carcinoma: a Pilot Retrospective Study

Fu, Si-Rui,Zhang, Ying-Qiang,Li, Yong,Hu, Bao-Shan,He, Xu,Huang, Jian-Wen,Zhan, Mei-Xiao,Lu, Li-Gong,Li, Jia-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: Sorafenib is a promising drug for advanced hepatocellular carcinoma (HCC); however, treatment may be discontinued for multiple reasons, such as progressive disease, adverse events, or the cost of treatment. The consequences of sorafenib discontinuation and continuation are uncertain. Materials and Methods: We retrospectively analyzed 88 HCC patients treated with sorafenib from July 2007 to January 2013. Overall survival (OS), post-disease progression overall survival (pOS), and time to disease progression (TTP) were compared for survival analysis. Cox proportional hazard regression was performed to assess the effect of important factors on OS in the overall patient population and on pOS in patients who continued sorafenib treatment. Results: Sorafenib was discontinued and continued in 24 and 64 patients, respectively. The median OS (355 vs 517 days respectively; p=0.015) and median post-PD OS (260 vs 317 days, respectively; p=0.020) were statistically different between the discontinuation and continuation groups. Neither the median time to first PD nor the time to second PD were significantly different between the 2 groups. In the discontinuation group, 3 of the 24 patients (12.5%) suffered disease outbreaks. In Cox proportional hazard regression analysis after correction for confounding factors, BCLC stage (p=0.002) and PD site (p=0.024) were significantly correlated with pOS in patients who continued sorafenib treatment. Conclusions: Sorafenib discontinuation may cause HCC flares or outbreaks. It is advisable to continue sorafenib treatment after first PD, particularly in patients with Barcelona Clinic Liver Cancer stage B disease or only intrahepatic PD.