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Antimutagenic Effects of Lycopene and Tomato Purée
Zdeňka Polívková,Petr Šmerák,Hana Demová,Milan Houška 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6
Several health benefits, including protection from tumors at various anatomic sites, such as the lungs, stomach, and prostate gland, have been attributed to tomatoes and tomato-based products. Among tomato carotenoids, lycopene is the most active antioxidant, although it has many other biological effects, but data on its antimutagenic effects are scarce and often discrepant. The aim of our work was to determine the protective effects of lycopene, with regard to mutagenicity, via two indirect mutagens/carcinogens—2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and aflatoxin B1 (AFB1) and the direct mutagen/carcinogen N-nitroso-N-methylurea (MNU)—using the Ames and micronucleus tests. The significant, dose-dependent, antimutagenic effects of two concentrations of lycopene (30μg and 300μg per plate) were demonstrated at various concentrations of both AFB1 and IQ in two strains of Salmonella typhimurium (TA98 and TA100). The protective effects of lycopene relative to MNU were lower in comparison to its protective effects relative to AFB1 and IQ. Mice treated for 3 days with different doses of lycopene (either 25 or 50mg/kg of body weight) prior to administration of individual mutagens resulted in a significant reduction of micronuclei numbers in the micronucleus test. Tomato purée (tested using the Ames test and AFB1) revealed a much stronger, dose-dependent, antimutagenic effect compared with corresponding doses of pure lycopene. Results indicate that lycopene has antimutagenic effects, although the effects are lower than that of tomato purée, which contains a complex mixture of bioactive phytochemicals. The antimutagenic effect is connected with the chemoprotective role of lycopene, tomatoes, and tomato products in the prevention of carcinogenesis.
Influence of feed on anti-inflammatory and antioxidant effects of Zophobas morio
Pečová Martina,Pospiech Matej,Javůrková Zdeňka,Ljasovská Simona,Dobšíková Radka,Tremlová Bohuslava 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.4
In this study, the antioxidant and anti-inflammatory effects of superworm as one of the potential species for the food industry were investigated. This type of insect was bred on three different types of feed and, at the end of the breeding experiment, the total polyphenols (TPC), antiradical activity, degree of hydrolysis, and antiinflammatory effects of the peptides were determined. The highest value of polyphenols content was demon strated in whole enzymatically hydrolysed insects (W), especially in the group fed on soy feed (Wso = 4.2014 ± 0.27 mg GAE/100 g). This group also achieved the highest antiradical activity, as measured by ABTS and DPPH, and the highest anti-inflammatory effect, as measured by COX inhibition. Insects fed on soy feed are unsuitable for food despite their high polyphenol content and antioxidant activity, as high mortality occurs. The largest length in a worm breeding experiment was identified in the group fed the control diet (co = 4.93 ± 0.27 cm) and the heaviest weight in the group on the maize diet (ma = 0.77 ± 0.11 g).