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Syed Zama Ali,Michael John Clarke,Anbalagan Kannivelu,Dinesh Chinchure,Sivasubramanian Srinivasan 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.3
Extramedullary pulmonary hematopoiesis is a rare entity with a limited number of case reports in the available literature only. We report the case of a 66-year-old man with known primary myelofibrosis, in whom a Technetium-99m sulfur colloid bone marrow scan with single-photon emission computed tomography (SPECT)/CT revealed a pulmonary hematopoiesis asthe cause of pulmonary hypertension and severe tricuspid regurgitation. To the best of our knowledge, this is the first description of Technetium-99m sulfur colloid SPECT/CT imaging in this rare condition.
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Enhanced electrochemical strain in polypyrrole films
Takaharu Nakashima,Devendra Kumar,Wataru Takashima,Tetsuji Zama,Susumu Hara,Shingo Sewa,Keiich Kaneto 한국물리학회 2005 Current Applied Physics Vol.5 No.2
Electrochemomechanical characteristics of polypyrrole (PPy) lms, electrodeposited from tetra-n-butylammonium triuorometh-ane-sulfonate dissolved in methyl benzoate (PPyFMS), have been investigated using a simultaneous measurement of electrochem-omechanical deformation (ECMD) with cyclic voltammetry (CV) by comparing with PPy lms deposited fromp-phenol sulfonate inaqueous media (PPyPPS). The ECMD magnitude of PPyFMS lm was reached around 9% at 1st cycle and was decreased to beabout 3.2% at 20th cycle with electrochemical cycling in 1 M NaPF6. While in 1 M NaCl solution, the ECMD magnitude was1.9% at 20th cycle in CV measurement. In the case for the PPyPPS lm, ECMD magnitude at 20th cycle was around 0.8% and1.1% in 1 M NaPF 6 and 1 M NaCl solutions, respectively. The results indicate that the combination of electrolytes employed inboth the electrodeposition and the device actuation plays the very important role for achieving the enhancement of ECMD magn-itudes. In the case of ECMD behaviors, it was found that the electrolyte used in the lm actuation determines the ECMD charac-teristics..
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Meriem Laraba,Sana Hazar Tachour,Hanene Belbache,Nassima Boubekri,Radja Djebbari,Fadila Benayache,Samir Benayache,Djamila Zama 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.4
Doxorubicin (DOX) is a potent anticancer drug; its use has been limited by its hepatotoxicity, which is due to free radicals generation. This work aims to investigate whether the n-butanol soluble part of the 70% methanol extract of the aerial parts of Moricandia arvensis, alleviates doxorubicin-induced hepatotoxicity. According to the literature data, Moricandia arvensis (Brassicaceae) is renowned for its richness in flavonoid and phenolic acid glycosides. In this work, we have rightly assessed the total phenolic and flavonoid contents of the studied extract (n-butanol extract). The results obtained (TPC: 86.25 ± 0.00 μg GAE/mg; TFC: 22.54 ± 0.01 μg QE/mg) encouraged us to continue our investigations. Wistar albino rats were orally administered with n-butanol extract of M. arvensis (50 mg/kg and 100 mg/kg body weight) or vitamin E as a standard antioxidant (100 mg/kg) for 10 days; and DOX (15 mg/kg on the 8th day that was intraperitoneally injected. At the end of the experiment, blood and liver samples were analyzed for biomarker levels and histopathological changes. Liver homogenates were used to determine oxidative stress parameters such as malondialdehyde (MDA), glutathione peroxidase ( GPX) and glutathione (GSH) activity. DOX-administered rats significantly increased different levels of the serum biochemical parameters, increased TBARS level, decreased GPx activity and GSH level in the liver. In addition, M. arvensis (50 mg/ kg and100 mg/kg) n-butanol extract treatments significantly decreased the level of TBARS, increased GSH level and GPx activity compared to the DOX-treated rats (p < 0.01). The histological study revealed the hepatoprotective effects of the tested extract on DOX-induced toxicity. This was demonstrated by the preservation of hepatic architecture as well as a reduction in structural and functional changes in the liver. The obtained results indicate a protective action of n-butanol extract of M. arvensis that could be the result of the inhibition of reactive oxygen species (ROS) generation. This may be the result of the presence of phenolic compounds in M. arvensis plant.
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