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Yu Xiao,Bing Wang,Yulian Chen,Lingqiang Chen,Zhenkai Lou,Zhiqiang Gong 대한척추신경외과학회 2023 Neurospine Vol.20 No.1
Objective: To identify potential risk factors for cerebrospinal fluid (CSF) leakage after craniovertebral junction (CVJ) anomaly surgery and to provide a reference for clinical practice. Methods: Sixty-six patients who underwent elective CVJ anomaly surgery during a 6-year period (April 2013 to September 2019) were retrospectively included. Research data were collected from the patients’ medical records and imaging systems. Patients were divided into CSF leak and no CSF leak groups. Univariate tests were performed to identify potential risk factors. For statistically significant variables in the univariate tests, a logistic regression test was used to identify independent risk factors for CSF leakage. Results: The overall prevalence of CSF leakage was 13.64%. Univariate tests showed that a basion-dental interval (BDI) > 10 mm and occipitalized atlas had significant intergroup differences (p < 0.05). Multivariate analysis indicated that a BDI > 10 mm was an independent risk factor for CSF leakage, and patients with CVJ anomalies with a BDI > 10 mm were more likely to have postoperative CSF leaks (odds ratio, 14.67; 95% confidence interval, 1.48–30.88; p = 0.004). Conclusion: It is necessary to maintain vigilance during CVJ anomaly surgery in patients with a preoperative BDI > 10 mm to avoid postoperative CSF leaks.
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Yu Xiao,Fen Li,Anyuan Zheng,Qibing Chen,Fuhai Chen,Xiang Cheng,Zezhang Tao 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.8
Even though nasopharyngeal carcinoma (NPC) is not common worldwide, it is a major public health burden in endemic areas. Distant metastasis often leads to a poor prognosis for NPC; therefore, new and effective anticancer strategies are needed. Ginkgolic acid (GA) is small-molecule compound existing in Ginkgo biloba that has various biologically relevant activities, including antitumor properties; however, its effects and mechanism of action in NPC are unknown. The effects of GA on NPC and such underlying mechanisms were investigated using 5–8F and CNE2 cells and NP69 human immortalized nasopharyngeal epithelial cells in this study. Moreover, the xenograft models were built to examine GA's effection in vivo. GA treatment decreased the survival and invasive capacity of 5–8F and CNE2 and induced their apoptosis, which varied with dose; this was accompanied by downregulation of B cell lymphoma (Bcl)2, upregulation of Bcl2-associated X protein, and activation of poly-ADP ribose polymerase, and caspase-9/-3. G0/G1 phase arrest was induced by GA in NPCs. It also reduced the expression of cyclin-dependent kinase 6 and its regulators cyclin D2 and cyclin D3. GA inhibited the activation of protein kinase B/nuclear factor signaling; this effect was potentiated with GA and 5-fluorouracil (5-FU), which also enhanced 5-FU-induced apoptosis. In summary, GA may be effective as an adjuvant to conventional chemotherapy drugs in preventing the progression of NPC.
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Yuxiao Wang,Guangyin Du,Songyu Liu,Dingwen Zhang 대한토목학회 2022 KSCE Journal of Civil Engineering Vol.26 No.10
The resonance probe compaction (RPC) method is an effective technique for particular soils, which mainly includes sandy and loess. However, the application of RPC on contaioning clay interlayer area has never been seen. In this study, a successful case of using the RPB method to treat the clay interlayer foundation is presented in detail. The test results of Huaiyan high-speed railway construction project are introduced. The test is divided into the laboratory test and the field test, mainly including standard penetration test (SPT), cone penetration test (CPT) and seismic wave cone penetration test (SCPT). The test results indicated that the cone resistance of silt and silty sand layers increased to an average of 2.13 times compared with an average of 4.39 MPa before treatment, and the sleeve friction whose initial average is 54.17 kPaincreased to an average of 1.74 times. The existence of the clay interlayer does not affect the consolidation and drainage of the silt layer and the silt sand layer, and after the construction, the excess pore water pressure around the vibration point can be dissipated by more than 90% within 15 minutes. After reinforcement, the standard penetration number of subsoil, increased by about 15% − 95% compared with an average of 19 blows before treatment and the clay particle content of some clay interlayers are reduced to less than 10%. The shear wave velocity of the subsoil in the treatment depth increased by about 15% − 48% compared with 140 m/s before treatment. The RPC method was successful for the coastal phase liquefaction foundations.
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( Yuxiao Dong ),( Juyoung Chang ) 한국디자인트렌드학회 2017 한국디자인포럼 Vol.56 No.-
Background This study primarily discusses the links and connections of imaginary creatures illustrations between two ancient books: "Classic of the Great Wilderness"(山海經) and "Strange Animals Book"(怪奇鳥獸圖卷). And this study compares and analyses their similarities, and investigates on their historical links between China and Japan. The main aim of this study is to find the relation between two books, to explore the value of those ancient books and to investigate their potential of application to contemporary design and other areas. Methods Literature research: By studying the imaginary creatures illustrations of two books in libraries and museums, and reviewed imaginary creatures that appear in "Classic of the Great Wilderness" and "Strange Animals Book", and then analysed them on a comprehensive and detailed basis. Case research: Representative creatures that appear in both Chinese and Japanese versions were selected for the analysis and comparison. Comparative research: By comparing the images of the imaginary creatures that appear in the two books, the study analyzed their links and relations, and then discussed their heritage in innovating and developing the traditional culture. Result By comparing the images of the imaginary creatures that appear in the two books, the study found the relation between them, identified their similarities, and analyzed their differences. The imaginary creatures in "Classic of the Great Wilderness" gave a big influence to the creation of "Strange Animals Book" as a reference. The imaginary creatures after the integration of the Japanese local imaginary creatures culture system and gradually evolved into a variety of Japanese imaginary creatures images that some are still active now. Although "Classic of the Great Wilderness" was written hundreds of years ago, it remains a creative gem that offers insight for innovation. A close correlation exists between valuable cultural inheritance and innovation. Conclusion According to the description and images of various imaginary creatures in "Classic of the Great Wilderness", the imaginary creatures are used as a reference in the creation of "Strange Animals Book" for depicting cultural elements from China. A number of them have been disseminated through local Japanese culture, and many classic Japanese monsters images are still well known today, such as Tengu(天狗). And with the evolution of these traditional images, they were known and loved by more people, and were used in various fields. Important traditional books such as “The Classic of the Great Wilderness” and "Strange Animals Book" are priceless sources for creating contemporary design and inspiration. Those ancient books left a great wealth on the art of thinking and imagination, so they are worth letting more people learn and study their mystery.
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( Yuxiao Dong ),( Juyoung Chang ) 한국디자인트렌드학회 2017 한국디자인포럼 Vol.54 No.-
Background This study primarily discusses the imaginary creatures and their illustrations found within the ancient Chinese book, “The Classic of the Great Wilderness (山海經)”. The main goal of this paper is to raise the people`s attention and understanding of "The Classic of the Great Wilderness". The purpose is to explore the value of this book and investigate its potential of application to contemporary design. Methods Three methods are used for this analysis. Literature research: Thoroughly analyzing "The Classic of the Great Wilderness" to achieve a comprehensive and detailed understanding, the paper analyzes the cultural characteristics and artistic features of traditional artistic images within the book. Character Analysis: This paper selects several representative images of interest, such as Gumiho, Emperor Jiang and tries to find similarities in the creative process of imagining these creatures. Comparative Research: by comparing the creatures image in“The Classic of the Great Wilderness”and the creatures in the film “Monster Hunt”and "monsters University". The similarities and differences are analyzed in order to inherit and develop the traditional culture. Result Although "The Classic of the Great Wilderness" was written many years before “Monster Hunt”and "Monster University" was created, similarities in design strongly connect the movie and the book. We can observe the extension of imagination from "The Classic of the Great Wilderness"” to “Monster Hunt.”and "Monster University". Conclusion Design consists of traditional and cultural elements. An important traditional book such as “The Classic of the Great Wilderness”is a priceless source for creating contemporary designs and a valuable source of inspiration. The mismatching of body parts, limbs and organs to creates monsters seems to be a universal cultural practice that has been going on since the ancient times. Discovering the book as a hidden creative gem from tradition can help us innovate. A close correlation exists between valuable cultural heritage and innovation.
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Yuxiao Zhu,Li Qian,Qing Liu,Jing Zou,Ying Zhou,Tao Yang,Gan Huang,Zhiguang Zhou,Yu Liu 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.2
Background: The detection of glutamic acid decarboxylase 65 (GAD65) autoantibodies is essential for the prediction and diagnosis of latent autoimmune diabetes in adults (LADA). The aim of the current study was to compare a newly developed electrochemiluminescence (ECL)-GAD65 antibody assay with the established radiobinding assay, and to explore whether the new assay could be used to define LADA more precisely. Methods: Serum samples were harvested from 141 patients with LADA, 95 with type 1 diabetes mellitus, and 99 with type 2 diabetes mellitus, and tested for GAD65 autoantibodies using both the radiobinding assay and ECL assay. A glutamic acid decarboxylase antibodies (GADA) competition assay was also performed to assess antibody affinity. Furthermore, the clinical features of these patients were compared. Results: Eighty-eight out of 141 serum samples (62.4%) from LADA patients were GAD65 antibody-positive by ECL assay. Compared with ECL-GAD65 antibody-negative patients, ECL-GAD65 antibody-positive patients were leaner (P<0.0001), had poorer β-cell function (P<0.05), and were more likely to have other diabetes-associated autoantibodies. The β-cell function of ECLGAD65 antibody-positive patients was similar to that of type 1 diabetes mellitus patients, whereas ECL-GAD65 antibody-negative patients were more similar to type 2 diabetes mellitus patients. Conclusion: Patients with ECL-GAD65 antibody-negative share a similar phenotype with type 2 diabetes mellitus patients, whereas patients with ECL-GAD65 antibody-positive resemble those with type 1 diabetes mellitus. Thus, the detection of GADA using ECL may help to identify the subtype of LADA.
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Proline Metabolism in Neurological and Psychiatric Disorders
Yuxiao Yao,Weiping Han 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.11
Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysregulated proline metabolism in neuronal dysfunction and consequently neurological and psychiatric disorders. We will discuss the association between genetic and protein function of enzymes in the proline pathway and the development of neurological and psychiatric disorders. We will conclude with a potential mechanism of proline metabolism in neuronal function and mental health.
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