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Yusuke Uchinami(Yusuke Uchinami ),Koichi Yasuda(Koichi Yasuda ),Hideki Minatogawa(Hideki Minatogawa ),Yasuhiro Dekura(Yasuhiro Dekura ),Noboru Nishikawa(Noboru Nishikawa ),Rumiko Kinoshita(Rumiko Kino 대한방사선종양학회 2024 Radiation Oncology Journal Vol.42 No.1
Purpose: To investigate the clinical significance of adaptive radiotherapy (ART) in locally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT). Materials and Methods: Eligible patients were treated with concurrent chemoradiotherapy using IMRT. Planning computed tomography in ART was performed during radiotherapy, and replanning was performed. Since ART was started in May 2011 (ART group), patients who were treated without ART up to April 2011 (non-ART group) were used as the historical control. The Kaplan-Meier method was used to calculate overall survival (OS), locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and distant metastasis-free survival (DMFS). LRFS for the primary tumor (LRFS_P) and regional lymph node (LRFS_LN) were also studied for more detailed analysis. Statistical significance was evaluated using the log-rank test for survival. Results: The ART group tended to have higher radiation doses. The median follow-up period was 127 months (range, 10 to 211 months) in the non-ART group and 61.5 months (range, 5 to 129 months) in the ART group. Compared to the non-ART group, the ART group showed significantly higher 5-year PFS (53.8% vs. 81.3%, p = 0.015) and LRFS (61.2% vs. 85.3%, p = 0.024), but not OS (80.7% vs. 80.8%, p = 0.941) and DMFS (84.6% vs. 92.7%, p = 0.255). Five-year LRFS_P was higher in the ART group (61.3% vs. 90.6%, p = 0.005), but LRFS_LN did not show a significant difference (91.9% vs. 96.2%, p = 0.541). Conclusion: Although there were differences in the patient backgrounds between the two groups, this study suggests the potential effectiveness of ART in improving locoregional control, especially in the primary tumor.
Yusuke Mizuuchi,Yoshitaka Tanabe,Masafumi Sada,Koji Tamura,Kinuko Nagayoshi,Shuntaro Nagai,Yusuke Watanabe,Sadafumi Tamiya,Kohei Nakata,Kenoki Ohuchida,Toru Nakano,Masafumi Nakamura 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.5
Purpose: Preoperative sarcopenia worsens postoperative outcomes in various cancer types including colorectal cancer. However, we often experienced postoperative anastomotic leakage in muscular male patients such as Judo players, especially in rectal cancer surgery with lower anastomosis. It is controversial whether the whole skeletal muscle mass impacts the potential for anastomotic failure in male rectal cancer patients. Thus, the purpose of this study was to clarify whether skeletal muscle mass impacts anastomotic leakage in rectal cancer in men. Methods: We reviewed the medical charts of male patients suffering from rectal cancer who underwent colo-procto anastomosis below the peritoneal reflection without a protective diverting stoma. We measured the psoas muscle area and calculated the psoas muscle index. Results: One hundred ninety-seven male rectal cancer patients were enrolled in this study. The psoas muscle index was significantly higher in patients with anastomotic leakage (P<0.001). Receiver operating characteristic curve determined the optimal cut-off value of the psoas muscle index for predicting anastomotic leakage as 812.67 cm2/m2 (sensitivity of 60% and specificity of 74.3%). Multivariate analysis revealed that high psoas muscle index (risk ratio [RR], 3.933; P<0.001; 95% confidence interval [CI], 1.917–8.070) and super low anastomosis (RR, 2.792; P=0.015; 95% CI, 1.221–6.384) were independent predictive factors of anastomotic leakage. Conclusion: This study showed that male rectal cancer patients with a large psoas muscle mass who underwent lower anastomosis had a higher rate of postoperative anastomotic leakage.
Hyper-Raman scattering of SrTi18O3
Yusuke Minaki,Yuhji Tsujimi,Makoto Nakanishi,Mika Kobayashi,Mitsuru Itoh,Ruiping Wang,Toshirou Yagi 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.IV
Hyper-Raman scattering experiment has been performed in the SrTi(18Ox 16O1..x)3 single crystal plate with x = 0:87. Raman inactive ferroelectric Eu Slater mode is directly detected in the tetragonal phase. The mode clearly shows a softening behavior and seems to cause the ferroelectric transition at Tc = 26 1 K.
Yusuke Sato 아시아영어교육학회 2021 The Journal of Asia TEFL Vol.18 No.2
This study examined the effects of three different types of corrective feedback (CF) on the acquisition of declarative/procedural knowledge of the English past tense in a foreign language (FL) classroom setting. The participants comprised Japanese university students, and five classes were assigned to recasts, explicit correction, metalinguistic prompt, task-only, and test control groups. The first three groups performed tasks designed to elicit past-tense forms and received CF. The task-only group performed the tasks without any CF, while the test control group completed pretests and posttests only. Participants’ declarative and procedural knowledge of the past tense was measured at the pretest, immediate posttest, and delayed posttest. The results generally showed that recasts and explicit correction were effective for the development of declarative knowledge of the structures, while metalinguistic prompts were beneficial for the development of procedural knowledge. Thus, metalinguistic prompts would be one of the best types of feedback to provide in an FL classroom setting to help learners develop procedural knowledge of past-tense forms. However, to effectively develop their declarative knowledge of past-tense forms, recasts and explicit correction should also be provided.
Conservative Loan Loss Allowance and Bank Lending
Yusuke TAKASU,Makoto NAKANO 한국유통과학회 2019 The Journal of Asian Finance, Economics and Busine Vol.6 No.3
The purpose of this study is to investigate the relation between conservative loan loss accounting practice of banks, defined as accounting behavior that increases loan loss allowances against expected credit losses, and bank lending. Furthermore, we specify the macroeconomic conditions reflecting debtors’ borrowing environments and analyze how these conditions affect the relation between conservative loan loss allowances and bank lending. Although existing literature reports that accounting conservatism has a direct effect on non-financial firms’ investment behavior, there is little evidence about an effect of conservatism on banks’ lending behavior. By exploiting data showing the links between individual Japanese firms and their individual lenders to control both loan demand and supply, we estimate OLS regressions to test the relationships among conservative loan loss allowance, bank lending, and macroeconomic conditions using a unique dataset containing bank–firm–year observations between 2001 and 2013. We find banks that have conservative loan loss allowances tend to provide fewer loans to firms with financing needs when macroeconomic conditions are good and these conservative banks are likely to provide more loans to firms when macroeconomic conditions are bad. Our findings suggest that reflecting expected credit loss into loan loss allowances can mitigate the procyclical behavior of banks.
NPI licensing and the logic of the syntax-semantics interface
Yusuke Kubota,Robert Levine 경희대학교 언어정보연구소 2021 언어연구 Vol.38 No.2
In this paper, we propose an explicit syntax-semantics interface of NPI licensing in Hybrid TLG. Hybrid TLG is a version of categorial grammar that inherits properties of both lexicalist and derivational variants of generative grammar, and it has been shown in our previous research (summarized in Kubota and Levine 2020) that it offers elegant analyses for a number of complex phenomena at the interface of syntax and semantics (especially in the domains of coordination and ellipsis) that turn out to be highly problematic for other grammatical theories. In the present paper, we extend our work to NPI licensing and report on some initial results suggesting that the flexible and systematic architecture of Hybrid TLG turns out to be successful in this domain too. Specifically, our approach captures interactions between NPI licensing (or polarity sensitivity) and other complex phenomena at the syntax-semantics interface including the scopal properties of modal auxiliaries, Gapping, and VP fronting.
( Yusuke Watanabe ),( Atsunori Tsuchiya ),( Shuji Terai ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1
Cirrhosis is a chronic condition that can lead to liver failure. Currently, the viable option for decreasing mortality is liver transplantation. However, transplant surgery is highly invasive. Therefore, cell-based therapy has been developed as an alternative. Based on promising findings from preclinical research, some new trials have been registered. One of them was autologous bone marrow cell infusion therapy and found that ameliorating liver fibrosis activated liver regeneration. Now, majority of trials focus on low-immunogenicity mesenchymal stem cells (MSCs) appropriate for allogeneic administration. However, despite about 20 years of research, only a limited number of cell-based therapies have entered routine practice. Furthermore, potential shortcomings of cell-based therapy include a limit on the number of cells, which may be administered, as well as their failure to infiltrate target organs. On the other hand, these research show that MSCs act as “conducting cells” and regulate host cells including macrophages via extracellular vesicles (EVs) or exosome signals, leading to ameliorate liver fibrosis and promote regeneration. Therefore, the concept of cell-free therapy, which makes use of cell-derived EVs or exosomes, is attracting attention. Cell-free therapies may be safely administered in large doses and are able to infiltrate target organs. However, development of cell-free therapy exhibits its own set of challenges and such therapy may not be completely curative in the context of liver disease. This review describes the history of cell-based therapy research and recent advances in cell-free therapy, as well as discussing the need for more effective therapies. (Clin Mol Hepatol 2021;27:70-80)