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Lithium Carbonate가 白鼠 賢臟에 미치는 影響에 關한 電子顯微鏡的 硏究
이형영,이무석,이귀행,임영진,노승호 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.2
To investigate the effects of lithium carbonate on rat (Sprague-Dawley) kidney cells, light and electron microscopic observation were made. Experimental rats received daily intraperitoneal injections of lithium carbonate in doses of 30 or 150mg/kg. These animals were killed on 6.13.20.30 days after the first injection. 1) In the distal convoluted tuble, the 30mg/kg lithium carbonate dosages caused progressive mitochondrial swelling, dilatation of cisternae of rough endoplasmic reticulum, generalized reduction of cell organelles, irregular basal infolding and diiatation of Golgi apparatus. In the proximal tuble, same dose of lithium carbonate caused appearance of lyscsomes, mitochondrial swelling, dilatation of cisternae of rough endoplasmic reticulum, and appearance of dense bodies. These cellular changes were more marked with the lapse of time. 2) In the distal convoluted tuble, the 150mg/kg lithium carbonate dosages produced destruction of basal infolding(which was more severe compared with those 30mg/kg dosage), many vesicles in cytoplasm and cytoplasmic swelling. In the proximal tuble, the same dosages of lithium caused appearance of lysosome, mitochondrial swelling, loss of mitochondrial crest, appearance of many vesicles. These celluar changes were also more marked with the lapse of time. 3) The present study demonstrated that usual dosage of lithium carbonate do affect the structure of the rat kidney.
권영규,이병욱,Kwon, Yung-Kue,Lee, Byung-Wook 대한한의정보학회 2005 大韓韓醫情報學會誌 Vol.11 No.1
Objective We wish that oriental medicine theses can now be searched for by computer. So we have studied thesaurus and keywords in OMIS(Oriental Medicine Information System) Methodologies We have compared the keyword with the Thesaurus in the OMIS. So We have analyzed those into the agreement rate and the disagreement rate. Repeatedly, we have analyzed the agreement rate and the disagreement rate in chronological order. Conclusions 1. As the most of authors don't know about thesaurus, So many keywords disagree with thesaurus. 2. Because thesaurus system is very difficult to general authors. So system administors must build synonym data base, if many authors easily use thesaurus system. 3. We have to require institute editor to modify editorial policy. Presently most of institute require only one foreign language keywords, but it must be required foreign and Korean language keywords. 4. We must study not only oriental medicine thesaurus but also the other science thesaurus.