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Yun Lyul Lee,Hyeok Yil Kwon,Hyung Seo Park,Hyoung Jin Park 대한생리학회-대한약리학회 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.1
<P> Aim of this study was to investigate if pancreatic polypeptide (PP) reduced the insulin action via the intra-pancreatic cholinergic nerves in the isolated rat pancreas. The pancreas was isolated from rats and perfused with intra-arterial infusion of modified Krebs-Henseleit solution containing 2.5 mM glucose at a flow rate of 1.2 ml/min. Simultaneous intra-arterial infusion of insulin (100 nM) resulted in potentiation of the pancreatic flow rate and amylase output which were stimulated by cholecystokinin (CCK, 14 pM). These potentiating actions of insulin on the CCK-stimulated pancreatic exocrine secretion were completely abolished by administration of rat PP. Vesamicol, a potent inhibitor of vesicular acetylcholine storage, and tetrodotoxin (TTX) also significantly reduced the combined actions of insulin and CCK. Administration of carbamylcholine, an acetylcholine agonist, completely restored the vesamicol- or TTX-induced inhibition of the potentiation between insulin and CCK. Also rat PP failed to attenuate the restoring effect of carbamylcholine. Electrical field stimulation (15-30 V, 2 msec and 8 Hz) resulted in a significant increase in the pancreatic flow rate and amylase output in voltage-dependent manner. Effects of electrical field stimulation were augmented by endogenous insulin. Rat PP also suppressed the pancreatic exocrine secretion stimulated by electrical field stimulation. These observations strongly suggest that PP inhibits the potentiating actions of insulin on CCK-stimulated pancreatic exocrine secretion by suppression of the intra-pancreatic cholinergic activity in the isolated rat pancreas.
Lee, Yun-Lyul,Kwon, Hyeok-Yil,Park, Hyung-Seo,Park, Hyoung-Jin The Korean Society of Pharmacology 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.1
Aim of this study was to investigate if pancreatic polypeptide (PP) reduced the insulin action via the intra-pancreatic cholinergic nerves in the isolated rat pancreas. The pancreas was isolated from rats and perfused with intra-arterial infusion of modified Krebs-Henseleit solution containing 2.5 mM glucose at a flow rate of 1.2 ml/min. Simultaneous intra-arterial infusion of insulin (100 nM) resulted inpotentiation of the pancreatic flow rate and amylase output which were stimulated by cholecystokinin (CCK, 14 pM). These potentiating actions of insulin on the CCK -stimulated pancreatic exocrine secretion were completely abolished by administration of rat PP. Vesamicol, a potent inhibitor of vesicular acetylcholine storage, and tetrodotoxin (TTX) also significantly reduced the combined actions of insulin and CCK. Administration of carbamylcholine, an acetylcholine agonist, completely restored the vesamicol- or TTX-induced inhibition of the potentiation between insulin and CCK. Also rat PP failed to attenuate the restoring effect of carbamylcholine. Electrical field stimulation (15-30 V, 2 msec and 8 Hz) resulted in a significant increase in the pancreatic flow rate and amylase output in voltage-dependent manner. Effects of electrical field stimulation were augmented by endogenous insulin. Rat PP also suppressed the pancreatic exocrine secretion stimulated by electrical field stimulation. These observations strongly suggest that PP inhibits the potentiating actions of insulin on CCK -stimulated pancreatic exocrine secretion by suppression of the intra-pancreatic cholinergic activity in the isolated rat pancreas.
송아지 설사에 영향을 미치는 사육밀도 및 축사 방위와의 상관관계에 관한 연구
이윤렬 ( Yun Lyul Lee ),이학림 ( Hak Rim Lee ),안재범 ( Jae Bum Ahn ),송지예 ( Ji Ye Song ),장재진 ( Jae Jin Jang ),이민재 ( Min Jae Lee ) 한국동물위생학회 2007 韓國家畜衛生學會誌 Vol.30 No.1
This study was conducted to determine the effective environmental control measures in preventing calf diarrheal disease in farms. It was found that the high numbers of calves in a cow house was directly related with the high incidence rate of diarrheal diseases. When the number of calves was increased in a cow house, it was difficult to reduce the diarrheal diseases of calves. It was revealed that the incidence rates of calf diarrheal disease were dramatically reduced when the delivery house which faced south. The periodical changes of bedding materials seemed beneficial good to control the possible resident infectious agents, including pathogenic viruses and bacteria. The control of the delivery time was important for reduction of calf diarrhea. It was revealed that September and October were the best time as the delivery period. In order to use old cow house as a delivery house, it should be sterilized by the disinfectant and the flame. When the diarrheal feces were removed as soon as possible, the transmission of diarrheal diseases among calves in the same house was reduced. When the diarrheal feces were not disposed, the incidence rate of diarrhea reached up to 50%. When the morbid calves were not quarantined, the incidence rate of diarrhea was 100%. In contrast, when the diseased calves were quarantined from other calves, the incidence rate of diarrhea was reduced, remarkably. The mean recovery time from the diarrhea of the treated calves in the southern cow house was much faster than that in the north cow house. The treatment of calves in a clean and well-ventilated cow house with dry bedding was more effective than that in a cold, wet, and dark house. It could be postulated that the most important environmental factor in the reduction of diarrheal diseases of calves is the blocking of the entry of the infectious agents. The complete sanitation and control of the delivery house in the using farm is more important than building a new cow house, for prevention of calf diarrheal diseases.
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 간세포암종의 진단 및 치료 후 추적 관찰에서 혈청 PIVKA-2의 임상적 효용성
윤영준 ( Yun Yeong Jun ),한광협 ( Han Gwang Hyeob ),김철 ( Kim Cheol ),전재윤 ( Jeon Jae Yun ),문영명 ( Mun Yeong Myeong ),한창훈 ( Han Chang Hun ),최혜진 ( Choe Hye Jin ),이경률 ( Lee Gyeong Lyul ),김현숙 ( Kim Hyeon Sug ) 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
( Yun Soo Hong ),( Yang Won Min ),( Poong Lyul Rhee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Multiple rapid swallow (MRS) during esophageal manometry is a simple provocative maneuver, which could predict esophageal peristaltic reserve. We aimed to assess the value of MRS in patients with ineffective esophageal motility. Methods: Between November 2013 and July 2014, a total of 36 patients showing ineffective esophageal motility (IEM) on esophageal manometry were included in the study. We analyzed contractions after MRS. If a contraction after MRS stronger than that of single swallow, MRS was considered normal. The patients were classifi ed as having normal/abnormal MRS and differences between groups were tested in terms of proportions of gastroesophageal refi ux disease (GERD), pathologic acid exposure (PAE) and pathologic bolus exposure (PBE) and total AE and BE times (%). PAE and PBE was defi ned as an intraesophageal pH of <4 for more than 4.2% and refi uxate in contact with distal impedance electrodes for more than 1.4% of the recording time, respectively. Results: After exclusion of 4 patients with unavailable MRS results, 32 were analyzed. Of them, 15 patients (46.9%) had abnormal post-MRS response. The proportion of GERD, PAE and PBE did not show statistically signifi cant differences between the two groups (abnormal MRS group vs normal MRS group, 46.7% vs 35.3%, P=0.513; 40.0% vs 8.3%, P=0.135; 60.0% vs 33.3%, P=0.391). Total AE and BE time (%) was longer in abnormal MRS group than normal MRS group although it did not reach statistical signifi cance (4.2% vs 1.6%, P=0.125 and 3.7% vs 1.4%, P=0.237, respectively). Conclusions: Our results show that ineffective esophageal motility patients with abnormal post-MRS response have a tendency to be accompanied by more prolonged acid and/or bolus refi ux than those with normal response. Further large scaled study is warranted to confi rm out results in the future.
Two Distinct Types of Hypercontractile Esophagus: Classic and Spastic Jackhammer
( Yun Soo Hong ),( Yang Won Min ),( Poong-lyul Rhee ) 대한간학회 2016 Gut and Liver Vol.10 No.5
Hypercontractile esophagus (nicknamed jackhammer esophagus) is a recently defined disease within the esophageal motility disorders classification. Responses to treatments for jackhammer esophagus have been inconsistent in previous trials, possibly due to its heterogeneous manifestation. Thus, we reviewed 10 patients diagnosed with jackhammer esophagus and compared their clinical and manometric features at baseline. Additionally, manometric and symptomatic responses after treatment with known smooth muscle relaxants, including anticholinergic drugs (cimetropium bromide and scopolamine butylbromide) and a phosphodiesterase-5 inhibitor (sildenafil) were compared. We observed two distinct subgroups in the findings: one with hypercontractility and normal distal latencies ("classic jackhammer esophagus," n=7) and the other with hypercontractility and short distal latencies ("spastic jackhammer esophagus," n=3). The two types also differed in their responses to medications in that symptoms improved upon treatment with an anticholinergic agent in classic jackhammer esophagus patients, while spastic jackhammer esophagus was unresponsive to both the anticholinergic drugs and the phosphodiesterase-5 inhibitor. In conclusion, hypercontractile esophagus may be a heterogeneous disease with different underlying pathophysiologies. We introduced two novel terms, "classic jackhammer esophagus" and "spastic jackhammer esophagus," to distinguish the two types. (Gut Liver 2016;10:859-863)