실험적 진폐증에서 투여약제에 따른 면역학적 병리학적 조직변화

윤임중,임현우,노영만,오상용,정장영,임영,김경아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1993 韓國의 産業醫學 Vol.32 No.2

To access the effects of some drugs such as piperazine phosphare, azathioprine and allopurinol in the experimental pneumoconiosis, 263 rats weighted 240-320 gm was divided into the control and eight experimental groups. To each group, the turbid solution mixed free silica, talc and natural coal dust of 50 mg in 0.8 ml saline were instilled intratracheally. At the begining and 5th week of experiment, piperazine phosphate(8mg/week orally), aspirin(1.5mg/day intramuscularly), azathioprine(25mg/day orally) and allopurinol(1.5mg/day orally) were administered simultaneously, while the dust turbid solution was only given to the control group. For each group the change of body weight. dry right lung weight, cellularity including total cell, macrophage, lymphocyte and neurtrophil in bronchoalveolar lavage fluid, superoxide ion, hydroxyproline, leukotriene B₄, tumor necrotsis factor, prostaglandin E₂were examined, and observed the pathological chages in lung tissue. The results were as follow : 1. The larger amount of their instilled dust and the longer observation period, the severer pathological findings were found in the lung tissue of each experimental group. 2. The body and dry right lung wight was not significantly changed in the experimental groups compared with the control group. 3. The number of total cell in bronchoalveolar lavage fluid was markedly less in the experimental group than the control one, while no significant difference was found in the percent alveolar macrophages and lymphocytes in both groups. However, the percent of neutrophiles was usually lower than in the control group. 4. The amount of superoxide ion was frequently less in the experimental group compared with the control one. 5. The amount of hydroxyproline was significantly lower in the experimental group than in the control one. 6. The amount of leukotriene B₄was usually less in the drug administered group than in the control one. 7. The amount of tumor necrotic factor was also frequently lower in each experimental group than in the control one. 8. The amount of prostaglandin E₂was usually higher in each experimental group than in the control one.

등척성 운동 시 요추의 각도에 따른 중앙주파수와 토크의 특성

박경희,권오윤,장근,강성재,김영호 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.2

Fatigue is the decline in force produced as a result of prolonged muscle activity. Localized muscle fatigue can be identified by a shift toward low in the frequency components of the EMG signal, typically represented by a fall in the median frequency. Previous studies show that a shortened muscle developes a higher fatigue than elongated muscles. The purpose of this study was to investigate the time-related change of median frequency and torque during maximal isometric back extension exercises at different exercise angles (0˚, 12˚, 36˚, 72˚). Twenty healthy subjects (mean age = 24.35 ± 2.70) were evaluated in this study. Median frequency was extracted from the EMG signals by fast Fourier transform (FFT). Initial median frequency and the slope of median frequency change over time were computed from linear regression analysis. Pearson's product moment correlation was used to quantify the relationship between scope of median frequency and torque. The results were as follows: 1) Significant differences in y-intercepts of torque regression equation with respect to exercise angle were shown. However, there were no differences in the slopes of the median frequency and torque, and y intercept of the median frequency among exercise angles. 2) There was no significant correlation between slope of median frequency and torque. 3) But there was moderate correlation between median frequency and torque at each exercise angle. In conclusion, the exercise angle during maximal isometric back extension exercise is not a direct effect on slope of median frequency and torque. But results showed that median frequency and torque shift were highly correlated in all subjects.

새로운 백금착체인 tetrachloro [bis(2-chloroethyl)ethylenediamine-N,N']platinum(IV)과 cisplatin이 마우스의 면역반응에 미치는 영향

표명윤,유경미,최지선,오현정 숙명여자대학교 약학연구소 1993 약학논문집-숙명여자대학교 Vol.9 No.-

Effects of a new platinum complex, tetrachloro-[bis(2-chloroethyl) ethylenediamine-N,N']platinum(IV)[PtCl₄-2(CEen)] and cisplatin on the immune response were investigated. Male ICR mice were treated at the respective LD50(20% or 60% LD50) of cisplatin and PtCl₄-2(CEen). The results were as following : LD50 of PtCl₄-2(CEen) for male ICR mouse was 122.5mg/kg(i.p.) and higher than cisplatin(16.3mg/kg, i.p.). Body-, spleen-, thymus-, liver-weight, number of WBC and RBC were reduced dependently on the dose and day of administeration of cisplatin and PtCl₄-2(CEen). But these toxicities produced by PtC^-^CEen) appeared to be relatively less and to improve faster than by cisplatin. The titers of hemagglutinin and hemolysin to SRBC in mice received cisplatin and PtCl₄-2(CEen) were decreased significantly and independently on the day of antigen injection. Cisplatin and PtCl₄-2(CEen) stimulated significantly contact hypersensitivity to DNFB when administered prior to sensitization(DNFB), but suppressed slightly when administered after sensitization.

근관 전색재의 방사선 불투과성에 관한 비교연구

김태민,김서경,황인남,황윤찬,강병철,윤숙자,이재서,오원만 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.1

This study was performed to assess the radiopacity of a variety of root canal sealers according to the Specification concerning root canal sealers. Ten materials including Tubli-Seal™, Kerr Pulp Canal Sealer™, AH 26^(R), AH plus^(R), AH plus jet™, Ad seal™, Sealapex™, NOGENOU™, ZOB seal™, Epiphany™, and dentin were evaluated in this study. In the first part. densitometric reading of an each step of aluminum step wedge on occlusal film was performed at different voltage and exposure time. In the second part, ten specimens were radiographed simultaneously with an aluminum step wedges on the occlusal films under decided condition. The mean radiographic density values of the materials were transformed into radiopacity expressed equivalent thickness of aluminum (mm Al). The following results were obtained 1 Among the various conditions, the appropriate voltage and exposure time that meet the requirement density was 60 kVp at 0.2 s 2 All of the materials had greater radiopacity than 3 mm Al requirement of ANSI/ADA specification No. 57 (2000) and ISO No. 6876 (2001) standards. 3 The radiopacity of materials increased as thickness of materials increased. 4 The mm Al value of each specimen at 1mm in thickness has a significant difference in the statistics. It suggests that root canal sealers have a sufficient radiopacity that meet the requirement. 다양한 근관전색제는 방사선 사진상 주위 해부학적 구조와 구별될 만한 방사선 불투과성을 나타내야 한다 따라서 이런 물질들이 근관에 충전될 때의 방사선 불투과성 정도를 평가해야 할 필요성이 대두되고 있다. 본 실험에서는 다양한 근관전색제들의 방사선 불투과성을 평가하고자, 방사선 노출조건에 따른 aluminium step wedge에 대한 광학 밀도를 알아보고, 그 중 적절한 노출조건을 선택하여 수종의 근관 전색재의 방사선 불투과성 정도를 알루미늄 두께로 환산하여 비교해 보고자 한다. 방사선 불투과성의 기준을 위해 11개의 step으로 구성된 aluminum step wedge을 사용하여, 60kVP, 70kVp관전압 상태에서 각각 0.2, 0.3, 0.4초 그리고 0.2, 0.3, 0.33초의 꼭 노출시간으로 교합필름상에서 방사선 촬영후 적절한 노출 조건을 구하였다. 직경 5mm 각각의 두께 0.5, 1.0, 1.5, 2.0, 2.5, 3.0 mm인 10종 (Tubli-Seal™, Kerr pulp Canal Sealer™, AH26^(R), AHplus^(R), AH plus jet starter kit™, Ad seal™, Sealapex™, Nogenol root canal sealer™, ZOB seal™, Epiphany™)의 근관전색재 시편을 각 재료와 두께당 10개씩 제작한 후, 동일한 두께의 상아질 시편, aluminum step wedge와 함께 정해진 노출시간에 따라 방사선 촬영을 하였다. 모든 필름은 자동현상기로 현상하였다. 시편의 방사선 흑화도를 densitometer로 5회 반복 측정 후, 평균값을 구하여 알루미눔 두께로 환산하였다.얻어진 정보를 분석하여 다음의 결과를 얻었다. 1 관전압 60 kVp에서 노출시간 0.2, 0.3, 0.4초, 70 kVp에서 0.2, 0.3, 0.33초로 변화를 주어 방사선 촬영을 하였을 때 흑화도가 ISO No. 6876 규격에 가장 적합한 것은 60 kVP, 0.2초 일 경우였다. 2 측정된 근관 전색제의 방사선 불투과성은 2.29 mm Al (N0GEN0L)로부터 13.69 mm Al (AH Plus jet)까지 다양하게 나타났으나, 모두 ANSI/ADA specification (2000) 또는 ISO No. 6876 (2001) 규격이 제시한 최소한 3mm Al 이상의 방사선 불투과성을 지녀야 한다는 기준에 적합하였다. 3 재료의 두께가 증가할수록 방사선 불투과성은 증가하지만, 정비례하지는 않았다. 4 각 실험재료의 1 mm 두께의 시편에 대한 mm Al값들은 통계적으로 유의한 차이가 있었다. 이상의 결과는 본 실험에 사용된 수종의 근관 전색재는 모든 규격에 적합한 방사선 불투과성을 가지고 있음을 시사한다.

신고리 지역 기상관측을 통한 계절별 대기안정도 특성분석

송상근,김유근,오인보,정주희,조윤미,우경은,강태훈 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-

In this study, we analyzed the characteristics of atmospheric stability to investigate local environment change at an atomic power plant in Gori region. The used data was obtained from field observation of major meteorological variables such as wind direction and speed, air temperature, relative humidity, and solar radiation using AWS (Automatic Weather System) in Gori region from February to September in 2003. As a result, when strong northerly winds (more than 4~6 m/s) and weak northwesterly winds (2~3m/s) blow, atmospheric stability was neutral and stable from winter to spring, respectively. Atmospheric stability (neutral) in summer was similar to that in two other seasons (winter and spring), but it was stable for weak southwesterly winds (2~3 m/s). Finally, atmospheric stability was neutral for strong winds (over 4~6 m/s) in fall without respect to wind direction, while that was stable for very weak winds (less than 2 m/s).

수종의 근관세척액과 Listerine의 항균성 비교 연구

김영훈,강민경,최은경,양소영,양인석,강인철,황윤찬,황인남,오원만 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.6

본 연구는 여러 가지 근관세척액(NaOCl, CHX, EDTA)과 구강세정제로 사용되는 Listerine을 근관감염균주인 Porphyromonas gingivalis와 Enterococcus faecalis를 상대로 항균효과를 비교하고 Listerine이 근관세척액으로 사용가능한지를 확인하고자 시행하였다. 본 연구에서는 Porphyromonas gingivalis ATCC 3327과 Enterococcus faecalis ATCC 29212의 표준균주를 사용하였다. 실험을 위한 근관세척제로 0.1%, 0.2%, 1%, 2% Chlorhexidine(CHX)과 0.5%, 1%, 2.5%, 5.25% NaOCl, 0.5M EDTA(18.6% EDTA). 그리고 Listerine원액을 이용하였다. 항균효과의 비교는 액체배지상에서 균주의 혼탁도와 한천 확산법을 이용한 억제대 비교로 하였다. 모든 실험군은 대조군과 비교시 근관내 균주에 항균성을 나타냈다(p < 0.001). 모든 농도의 NaOCl, CHX, 그리고 EDTA는 실험균주에서 높은 항균성을 보였다. 모든 실험에서 Listerine은 다른 근관세척제에 비해 낮은 항균성을 보였다. 결론적으로, Listerine이 E. faecalis와 P. gingivalis에 대해 항균성을 보이나, 일반적으로 사용되는 근관세척 액에 비해서는 현저히 낮은 항균성을 나타냄으로 근관세척 액으로 사용은 적합하지 않음을 나타냈다. The purpose of this study is to compare the antibacterial effect of Listerine on two microorganisms (P. gingivalis and E. faecalis) with various root canal irrigants (NaOCl, CHX, EDTA) and to identify possibility of using Listerine as a root canal irrigant. Porphyromonas gingivalis ATCC 3327 and Enterococcus faecalis ATCC 29212 were used in this experiment. For the test irrigants, 0.5%, 1%, 2.5%, 5.25% NaOCl, 0.1%, 0.2%, 1%, 2% CHX, 0.5M EDTA (18.6% EDTA) and Listerine were prepared. Distiled water was used as control. Two methods-1) Comparison of turbidity in broth and 2) Agar diffusion test-were used to determine the extent of antibacterial effect of Listerine and to compare it with that of NaOCl, CHX, and EDTA. All solutions tested were effective against two bacterial strains compared with control (p < 0.001). Any concentration of NaOCl, CHX, and EDTA showed similarly high effectiveness against all bacterial strains. In all experiment, Listerine showed significantly low antibacterial effect compared with the other root canal irrigants (p < 0.05). In conclusion, the results reflect remarkably low antibacterial effect of Listerine as compared with root canal irrigants in general so it is not suitable for the root canal irrigant.

창원지역에서의 대기오염물질 배출량 산정

김유근,박상철,문윤섭,오인보,황미경 부산대학교 환경문제연구소 2002 環境硏究報 Vol.20 No.-

Emissions of air pollutants (TSP, SO2, NO2, CO, and HC) was estimated in Changwon city that has the industrial complex and basin terrain. We found that the emissions of TSP, SO2, NO2, CO, and HC were 897 tons, 3,287 tons, 5,706 tons, 10,057 tons, and 1,470 tons for a year, respectively and the main source of air pollutants were vehicle. The ratios of vehicle emissions to total emissions ware TSP 63.8%, SO2 26.1%, NO2 65.5%, CO 91.0%, HC 94.4%. The ratios of industry emissions to total emissions were TSP 30.8%, SO2 60.2%, NO2 25.2%, CO 6.4%, HC 3.7%. The ratio of life emissions to total emissions are TSP 5.4%, SO2 13.7%, NO2 9.3%, CO 2.6%, HC 1.9%. The concentration distributions of air pollutants simulated by ISCST3 model were similar to its emission distributions, and relatively high concentrations of air pollutants occurred in the Palyong-dong (industrial area) and Banlim and Chungang (residual area).

서울 시내 4년제 남자 대학생의 우울과 흡연량, 흡연기간, 니코틴 의존도와의 관계

박지영,박소영,이미숙,백수진,신의경,예혜련,오승진,장윤정,조혜진,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

Background: With reports on the relation between smoking and depression appearing since 1980, it has become clear that depression is one of the psychodynamics of smoking, though there has been little or no progress made in the study of whether or not there is indeed a relation between depression and nicotine dependence. Purpose: The purpose of the study was to investigate the effects of depression on the amount and period of smoking and nicotine dependence among university man student smokers. Method: In periodical examination between 14 and 21, May, 2003, using 170 university male. The CES-D(Center for Epidemiologic Studies Depression) Scale and the FTQ(Fagerstrom Tolerance Qustionnaire) were utilized to measure the level of depression and nicotine dependency. The amount of smoking was calculated based on the number of cigarette used. Result: Results indicated that depression had something to do with amount of smoking. Nicotine dependence also was related to depression but total value was relatively low. finally the period of smoking had nothing to do with depression. Conclusion: The results of this study revealed that the amount of smoking of university man student smokers was very high. Both the amount of smoking and nicotine dependence were affected by levels of depression. Accordingly psychiatric nursing access such as emotional support is needed to manage depression and decrease smoking.

광물성 섬유의 수산이온기 생성이 흰쥐 폐포대식세포의 세포독성과 적혈구 세포막의 지질과산화에 미치는 영향

김경아,윤임중,김지홍,장황신,오민화,임영,박정일 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.3

There is some evidence suggesting that the mechanism of pulmonary toxicity of natural fibrous silicate, asbestos, is related to the generation of oxygen-based free radical. Especially the hydroxyl radical(·OH) is believed to be the most reactive one. ·OH is a potent toxic oxidant, ·OH is which means highly cytotoxic, genotoxic and carcinogenic. Nevertheless there has been no previous report about ·OH generation from man-made mineral fibers except asbestos. In this paper we tested the hypothesis that both cytotoxicity of alveolar macrophage and lipid peroxidation of erythrocytes are associated with ·OH production by mineral fibers in vitro. The results were as follows: 1. ·OH production in vitro was progressively increased by the concentration dependent pattern with the same mineral fiber. The production of ·OH in vitro by man-made mineral fiber was markedly decreased compared with that of natural mineral fiber except rock wool. 2. Lipid peroxidation of mineral fiber-exposed erythrocyte suspension was significantly increased compared with that of phosphate-buffered saline(PBS) control group. Lipid peroxidation in amosite and chrysotile group was larger than that of other mineral fibers. 3. There was a significantly positive correlation between ·OH production in vitro and lipid peroxidation of mineral fiber-exposed erythrocyte. 4. All of mineral fibers were related to the cytotoxicity of alveolar macrophage in concentration-dependent fashion. Chrysotile and amosite were more cytotoxic than crocidolite. Among man-made mineral fibers, ceramic fiber was the most cytotoxic to alveolar macrophage. The viability of alveolar macrophage exposed to asbestos was markedly decreased compared with that of man-made mineral fiver at the same concentration. 5. There was the significant negative correlation between the production of .OH and the viability of alveolar macrophages. From these results, we can conclude that the production of ·OH in vitro was strongly correlated with the cytotoxicity of alveolar macrophage and the lipid peroxidation in mineral fiber-exposed erythrocyte. And we documented that man-made mineral fiber could generate .OH in vitro less than asbestos.

Effects of Cosmetics Purchase Decision Factors of Female University Students in Korea and Taiwan on the Korea Cosmetics Satisfaction

Yun-Kyoung Oh 한국피부과학연구원 2020 아시안뷰티화장품학술지 Vol.18 No.4

목적: 한국과 대만의 20대 여대생을 대상으로 화장품 구매결정요인의 차이를 분석하고, 구매결정요인에 따른 한국화장품의 만족도 와의 관계를 파악함으로써 한국화장품 제품개발 및 소비자 마케팅에 대한 기초자료를 제공하고자 한다. 방법: 한국과 대만의 20대 여대생을 대상으로 2019년 12월 10일부터 2020년 3월 20일까지 설문지 법에 의한 자료수집을 실시하였다. 조사문항은 화장품 구 매결정요인, 화장품 만족도, 조사대상자의 일반적 특성, 화장품 사용특성으로 구성하였다. 설문지는 총 297부가 수집되었고 SPSS 18.0 통계프로그램을 사용하여 기술통계, 요인분석, 회귀분석을 실시하였다. 결과: 첫째, 화장품 구매의 주요 정보원은 한국과 대 만 모두 인터넷•SNS를 통해서 얻는 경우가 많았고 화장품 구매 장소의 경우 로드샵, 인터넷 쇼핑몰이 많았다. 둘째, 한국과 대만 여 대생의 구매결정요인은 품질, 디자인, 가격, 브랜드, 사용정보 5가지 요인으로 나타났으며 구매 평가차이를 알아본 결과 대만이 한 국보다 디자인과 가격을 더 고려하는 반면 한국이 대만보다 사용정보를 더 고려하는 것으로 나타났다. 셋째, 한국과 대만 여대생의 한국화장품에 대한 만족도는 보통 이상의 만족도를 나타냈으며 품질과 화장품 재구매 항목에 대한 만족도는 한국 여대생이 더 높았 다. 넷째, 화장품 구매결정요인이 한국화장품 만족도에 미치는 영향을 비교한 결과 화장품 구매 시 한국은 화장품의 품질과 사용정 보를, 대만은 품질, 브랜드, 사용정보를 중요하게 고려한 경우 만족도가 더 높게 나타났다. 결론: 한국 화장품에 대한 만족도를 높이 기 위해서 화장품 구매 시 한국과 대만 여대생이 제품의 품질과 사용정보를 구체적이고 정확하게 파악할 수 있도록 할 필요가 있으 며, 대만 여대생을 대상으로 한 경우에는 화장품 브랜드를 적극적으로 홍보하는 전략을 세울 필요가 있다 Purpose: The study analyzes and compares the factors of cosmetic purchase decision in female university students in South Korea (“Korea” hereafter) and Taiwan and elucidates their relationship with satisfaction in terms of Korean cosmetics. Methods: Data were collected via a questionnaire survey conducted from December 10, 2019 to March 20, 2020 among female university students in their twenties in Korea and Taiwan. The survey items focused on the factors of cosmetic purchase decision, satisfaction with cosmetics, general characteristics of the survey subjects, and characteristics of cosmetic use. A total of 297 questionnaires were collected and analyzed using SPSS 18.0. Results: First, the main sources of information for purchasing cosmetics were obtained through the Internet and social networking sites (SNSs) in Korea and Taiwan. Second, five factors of purchase decision were identified, namely, quality, design, price, brand, and usage information. Third, the satisfaction of Korean and Taiwanese female university students with Korean cosmetics was higher than average, whereas satisfaction with quality and cosmetic repurchase items was high for only the Korean students. Fourth, when purchasing cosmetics, the satisfaction rate was higher when the Korean students considered the quality and usage information of the cosmetics, whereas the Taiwanese considered quality, brand, and usage information. Conclusion: To increase satisfaction with Korean cosmetics, ensuring that female university students in Korea and Taiwan can accurately identify product quality and usage information when purchasing cosmetics is necessary. Alternatively, the Taiwanese students should develop strategies to actively promote cosmetic brands.