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Je‑Oh Lim,Je‑Won Ko,Tae‑Yang Jung,Woong‑Il Kim,So‑Won Pak,In‑Sik Shin,Won‑Kee Yun,Hyoung‑Chin Kim,Jeong‑Doo Heo,Jong‑Choon Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Silica dioxide nanoparticles (SiONPs) have been used for various medical applications, including therapeutics and imaging, and the use of SiONPs has increased gradually over the years. However, despite an increase in the use of SiONPs, not much is known about mechanism of action of SiONPs and their pulmonary toxicity. Objective The present study investigated the pulmonary toxicity of SiONPs and explored the underlying mechanism of action, primarily focusing on thioredoxin-interacting protein (TXNIP)/NOD-like receptor pyrin domain-containing 3 (NLRP3) in SiONPs-treated mice. We investigated the toxic effects of SiONPs in the lung of BALB/c mice administered 5, 10, and 20 mg/kg SiONPs for 3 days. Results Exposure to SiONPs markedly increased inflammatory cell counts, including those of neutrophils and macrophages, and levels of inflammatory mediators, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in a dose-dependent manner in the bronchoalveolar lavage fluid. Moreover, the inflammation was verified upon histopathological analysis. In addition, exposure to SiONPs increased the expression of TXNIP in a dose-dependent manner and, in turn, upregulated NLRP3 inflammasome proteins, which subsequently induced IL-1β production. Conclusion Collectively, exposure to SiONPs induced inflammation in the lungs of mice, which resulted in the activation of IL-1β production via the TXNIP-NLRP3 axis. Our results provide useful information on the pulmonary toxicity induced by SiONPs and provide insights into the underlying mechanism of action.
尹世重,趙泰璟,吳濟直,金溫植,金黎相 공주대학교 사범대학 과학교육연구소 1983 과학교육연구 Vol.15 No.1
Teaching materials available for the effective performance of laboratory exp-erimental work in middle school were developed: Physics part ; A measuring apparatus of uniformly accelerated motion and normal force of inclined plane was developed. Chemistry part ; An imploved Eudiometer applicable in measuring reaction mole ratio and usful for a gas generating apparatus was developed. Biology part ; convenient teaching materials observing law of dominance, law of segregation, law of independence, incomplete dominance and dihybrid cross were developed. Earth science part ; A laboratory teaching materials observing formation of wave, current and graded bedding, and identification of sedimentary rocks were developed. Putting the above results of study together, the integrated suggestions were made to the effective development of science education in middle school : 1. The contents of science textbook should be simplified to the direction of the understanding of essential principles and concept. 2. The development and dirtrihbution of various supplementary teaching materials (film, T.P., cassettes film, supplementary textbook, program teaching materials individual learning materials) are required. 3. The experimental laboratory should be equipped with common instruments and equipements. 4. Efforts and time are needed to science teachers, and so remission of sundry duties and arrangement of assistant are hopefully considered. 5. Teacher's research activities should be encouraged by administrative route or relevant institute.
하악골 신연술 후 생성된 신생골의 조직학적 및 면역화학적 소견
윤경인,박재억 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3
Distraction osteogenesis(DO) can be performed in the bony defect associated with trauma, anomaly, and various kinds of disease. The gap generated by DO is filled with growing callus : during the period of distraction, the osteogenesis is continued. However, there have been few reports about expression pattern of growth factors in newly formed bone during the consolidation periods. We performed DO in the mandibular defect case and studied the expressed pattern of growth factors. Its pattern was compared to that of the same patient. BMP-2 and -4 were strongly expressed in the DO site. Particularly, BMP-4 was not expressed in the normal mature bone, but expressed in new bone in DO. However, there was no difference in the FGF-7 expression between the sites. Therefore, strong expression of BMP-4 are related to new bone formation in DO and they may not be related to the normal homeostasis in human bone. Though FGF-7 is related to the growth of keratinocyte, it may have minimal role in the DO and normal mature bone.
문윤제 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3
The purpose of this study was to investigate 1) the validity and reliability of Sports Inventory for Pain(SIP) when used Korean athletes 2) the effect according to gender, injury-potential, performance levels, grade. The participants were 485 athlete's in elementary, middle·high school and university. The SIP was developed by Meyers et al(1992) and translated into Korean by 2 Ph.D sport psychologist, head coaches. Factor analytic procedure was used to determine SIP factors. Major SIP factors included direct copy, cognitive, catastrophizing, avoidance, body awareness. MANOVAs indicated significant gender(F5,475=2.67, p<.05), injury-potential(F5,475=2.20, p<.05), performance levels(F5,475=2.65, p<.05). Findings demonstrate that the SIP can be used to differentiate between gender, injury-potential, performance, thus providing partial confirmation of construct validity of the SIP. These findings may be used as a starting point for continued research delineating and contrasting pain coping response in sport athletes.
박제선,윤경구,이주형,최성용,김태환 강원대학교 부설 석재복합신소재 제품연구센터 1999 석재연 논문집 Vol.4 No.-
최근에 폴리프로필렌 섬유를 첨가하여 콘크리트의 인성을 증가시키고, 균열에 대한 저항성을 향상시키고자 하는 노력이 계속되어 왔다. 그러나 첨가된 섬유의 구조에 대한 이해부족으로 인하여 연구자들간에 실험결과에 대한 해석이 상이한 경우가 많았다. 이러한 연구의 일환으로 섬유의 첨가에 따른 건조수축 균열의 조절 가능성을 분석하기 위하여 섬유의 첨가에 따른 유동성과 건조수축의 변화를 조사하였다. 섬유의 첨가에 따른 유동성의 변화와 건조수축을 측정하기 위한 강제링 시편을 제작하였다. 본 연구에서는 섬유를 첨가한 콘크리트의 역학적 거동특성인 압축강도, 휨강도, 인성, 그리고 균열특성을 실험적으로 규명하고자 하였다. 본 연구는 강도 및 건조수축특성을 규명하기 위하여 수행되었고 섬유의 영향으로 인한 건조수축특성을 예견할 수 있다. Polypropylene Fibers have been used to increase the toughness of concrete and to increase the resistance to crack formation. However, there are many contradictory argument about the effectiveness of the fiber due to the lack of knowledge about the mechanism of fiber in concrete. In order to study the effect of fibers on possible crack control, the effects of fibers on workability and drying shrinkage have been studied. The workability change due to the addition of fibers has been studied, and full size concrete steel ring specimen have been cast at field to investigate the effect of fibers on the shrinkage properties. This laboratory have been performed to obtain the properties of pp fiber reinforced concrete such as compressive, flexural strength, toughness, slump, drying shrinkage crack and drying shrinkage characteristics. The present study was performed clarify the strength and drying shrinkage properties. From these results, we can expect the effect of the admixtures of polypropylene fiber for concrete and mortar about strength and drying shrinkage properties.
유윤종,류제천,임희대 忠南大學校 産業技術硏究所 2003 산업기술연구논문집 Vol.18 No.2
In this study, 1/8 model tests were carried out to understand the properties of the deep foundation and reinforced deep foundation. Also, carried out tests, divided into weathered rock and soft rock. The results of this study are summarized as follows; When piles is reinforced, reinforcing effect of soft rock is 1l-l2% and weathered rock is 233%. In the side load tests of weathered rock, reinforced effect was 223%. From the comparative study, the reinforced piles have enough reinforcing effect. Though some difference existed by foundations, reinforcing effect is reliable. Therefore reinforced deep foundation is profitable in the configuration of the earth.
박제선,김태경,이주형,윤청호 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-
The maturity concept was adopted to predict the strength of concrete, which was subjected to several temperature levels and variable curing conditions. Penetration test and compressive test were conducted to measure the initial and final setting time and the compressible strength of concrete specimen, respectively. Also, the temperature and time were measured at some time intervals for calculating the maturity. The initial and final setting were delayed as the w/c ration increased and curing temperature decreased. The relationships at the relative strength and the equivalent age were proposed at different w/c ratio for the several temperature curing conditions, and these were applied for the variable curing conditions.
조연제,석창성,김영진,양원호,최용식 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1
The objective of this paper is to investigate the constraint effect on fracture resistance curves. A series of fracture toughness tests with different specimen sizes taken from nuclear piping materials(SA312 TP347 SA516 Gr. 70) were performed. Test results show that fracture toughness is increased with increase in specimen size, probably due to the relaxation crack tip constraint. Elastic-plastic finite element analyses were also performed to investigate the constraint effect. Numerical results show that the stress triaxiality at the crack tip is the governing factor for fracture toughness.