건강검진 종목으로서 항갑상선 과산화효소 항체검사의 유용성에 대한 평가

김윤현,신용환,김지영,석재동,Kim, Yun-Hyun,Shin, Yong-Hwan,Kim, Ji-Young,Seok, Jae-Dong 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.1

Purpose: The test had been applied for outpatient by end of 2006, however, it has been included in the medical examination since January 2007, as demand and interests have been gradually increasing in the thyroid gland disease and cancer. thus, we would necessarily evaluate usefulness of the test by comparing the number of patients who are diagnosed as "benignancy" by the medical test with the number of outpatient who attend and are diagnosed as autoimmune thyroid disease among the benign patient, in samsung medical center for a certain period. Materials and Methods: Based on the result for Anti-TPO Antibody test by RIA for the 12,937 patients in samsung medical center from October 2007 to March 2008, for six months, benignancy rate classified by sex and age is measured statistically and number of the patients who are diagnosed as autoimmune thyroid disease are kept tracked on. Results: According to the analysis of the Anti-TPO antibody test 1,135 of 12,937, which is 8.77% are benign and 218 treated patient of them, which is 19.2%, were diagnosed as autoimmune thyroid disease. Conclusions: Based on the statistics, usefulness of the test seem to have co relationship with derivation of autoimmune thyroid disease. this is 19.2% of probability relatively high. this figure, however, does not have strong relationship with specialty of the disease. Thus screening test seems to have somewhat effectiveness, considering other experiments and their margin. 서론 : 항갑상선 과산화효소 항체검사는 하시모토 갑상선염과 그레이브스병 같은 자가면역성 갑상선질환을 진단하기 위한 임상적 의의가 있는 검사이다. 이 검사는 2006년 말까지 외래에서 주로 검사가 이루어졌으나, 점차적으로 갑상선 질환 및 암에 관심이 높아지고 그 수요가 상승됨에 따라 2007년 1월 부터 건강검진 검사의 하나로 채택되어 시행되고 있다. 이에 일정기간 동안 본원에 의뢰된 건강검진결과를 토대로 검사의 양성률과 양성환자의 자가면역성 갑상선 질환의 비율을 조사함으로써 본 검사의 유용성을 알고자 하였다. 실험재료 및 방법 : 2007년 10월부터 2008년 3월까지 6개월간 본원에서 실행한 건강검진 환자 12,937명의 항갑상선 과산화효소 항체검사에 대한 결과를 토대로 검사의 양성률을 성별 및 연령별로 알아보고, 양성 환자 중 검진 이후 외래로 내원하여 갑상선 관련 질환으로 진단이 된 수진자를 추적 조사한 후 상병명별로 분류하여 자가면역성 갑상선질환의 비율을 나타내보았다. 결과 : 항갑상선 과산화효소 항체검사의 분석 결과 총 12,937건(남자 7,644명, 여자 5,293명) 중 1,135건(남자 503명, 여자 632명)의 양성률(8.77%)를 보였으며, 특히 50대에서 높은 양성률을 보였다. 양성결과가 나온 수진자 중 218명(19.2%)이 갑상선 관련 질환에 대한 진단을 받았으며 그 중 112명(9.8%)가 자가 면역성 갑상선질환이었다. 고찰 : 본 검사의 유용성 판단 여부는 항갑상선 과산화효소 항체검사의 양성결과가 나온 수진자 중 자가면역성 갑상선 질환으로 진단된 환자수로 볼 수 있으며, 자가면역성 갑상선 질환으로 진단된 비율은 9.8%의 비교적 높은 수치를 나타내었다. 하지만 이러한 결과치가 본 검사에 대한 관련 질환의 높은 특이성을 나타낸다고 볼 수 없지만 이 외의 실험 및 오차들을 고려했을 경우 Screening검사로서 유용성을 보인다고 말할 수 있겠다.

LNG 화물창 방열재 균열에 따른 액화천연가스의 확산 및 온도 예측을 위한 수치 모델

이장현(Jang Hyun Lee),김윤조(YoonJo Kim),황세윤(Se Yun Hwang) 한국해양공학회 2014 韓國海洋工學會誌 Vol.28 No.6

The leakage of cryogenic LNG through cracks in the insulation membrane of an LNG carrier causes the hull structure to experience a cold spot as a result of the heat transfer from the LNG. The hull structure will become brittle at this cold spot and the evaporated natural gas may potentially lead to a hazard because of its flammability. This paper presents a computational model for the LNG flow and heat diffusion in an LNG insulation panel subject to leakage. The temperature distribution in the insulation panel and the speed of gas diffusion through it are simulated to assess the safety level of an LNG carrier subject that experiences a leak. The behavior of the leaked LNG is modeled using a multiphase flow that considers the mixture of liquid and gas. The simulation model considers the phase change of the LNG, gas-liquid multiphase interactions in the porous media, and accompanying rates of heat transfer. It is assumed that the N096-GW membrane storage is composed of glass wool and plywood for the numerical simulation. In the numerical simulation, the seepage, heat diffusion, and evaporation of the LNG are investigated. It is found that the diffusion speed of the leakage is very high to accelerate the evaporation of the LNG.

불평형 계통전압에 강인한 연료전지용 전력변환시스템의 PLL 방법

김윤현(Yun-Hyun Kim),김왕래(Wang-Rae Kim),임창진(Chang-Jin Lim),김광섭(Kwang-Seob Kim),권병기(Byung-Ki Kwon),최창호(Chang-Ho Choi) 전력전자학회 2008 전력전자학술대회 논문집 Vol.- No.-

In grid-interconnection system, a fast, robust and precise phase angle detector is most important to grid synchronization and the active power control. The phase angle can be easily estimated by synchronous dq PLL system. On the other hand under unbalanced voltage condition, synchronous dq PLL system has problem that harmonics occur to phase angle or magnitude of grid voltage because of the effect of the negative sequence components. So, To eliminate the negative sequence components, the PLL method using APF (All Pass Filter) in a stationery reference frame to extract positive sequence components under unbalanced voltage condition is researched. In this paper, we propose a new PLL method with decoupling network using APF in a synchronous reference frame to extract the positive sequence components of the grid voltage under unbalanced grid. The cut-off frequency of APF in a synchronous reference frame can be set to twice of the fundamental frequency comparing with that of APF in a stationery reference frame which is the fundamental frequency. The proposed PLL strategy can detect the phase angle quickly and accurately under unbalanced gird voltages. Simulation and experimental results are presented to verify the proposed strategy under different kind of voltage dips.

70 세 이상 여성 고령 환자에서 관상동맥 중재술

김윤아(Yun Ah Kim),정명호(Myung Ho Jeong),주신배(Shin Bae Joo),최명자(Myung Ja Choi),김인수(In Soo Kim),김남호(Nam Ho Kim),김건형(Kun Hyung Kim),이승욱(Seung Uk Lee),조장현(Jang Hyun Cho),안영근(Young Keun Ahn),조상기(Sang Ki Cho),조정 대한내과학회 2001 대한내과학회지 Vol.60 No.5

N/A Background : Previous reports have mentioned the increased mortality of percutaneous coronary intervention (PCI) in elderly female patients compared with elderly male. The purpose of this study was to evaluate the clinical characteristics, coronary lesion, characteristics and differences of success rate of PCI between male and female elderly patients. Methods : Three hundred sixty six elderly patients (454 lesions), including 210 male (255 cases, 73.4±2.45 year-old) and 156 female (199 cases, 73.5±2.55 year-old) who underwent PCI at Chonnam National University Hospital between Jan '96 and Dec '98 (out of 3,030 patients during same period). We compared clinical characteristic, coronary artery lesion morphology, success and complication rates of PCI in elderly male and female patients. Result : Clinical diagnosis and risk factors for atherosclerosis were not different between two groups. Right coronary lesions were more common in female and left circumflex artery lesion less common in female patients. The success rate of balloon angioplasty was 93.2% (110/118) in male and 93.3% in (98/105) in female patients, and the success rates of stenting were 99.2% (136/137) in male and 100% (94/94) in female. Success rates of PCI were not different between two groups. Procedure-related mortality was one cardiac death (1/255, 0.39%) in male group only. Complications of elderly male were two occlusive dissection (OD: 2/255, 0.8%), three thrombotic occlusion (TO: 3/255, 1.2%) and two ventricular arrhythmia (VA) with shock (2/255, 0.8%). In 199 female patients, three OD (3/199, 1.5%), three TO (3/199, 1.5%) and two VA (2/199, 1.0%) developed. The complications rates were not different two groups. Conclusion : PCI in female patients older than 70 years can be performed with comparable success and complication rates to those of elderly male patients.(Korean J Med 60:456-462, 2001)

풍력발전 출력 안정화를 위한 2㎹A급 BESS 적용 및 실증시험

김윤현(Yun-Hyun Kim),인동석(Dong-Seok In),김상현(Sang-Hyun Kim),김태형(Tae-Hyeong Kim),김광섭(Kwang-Seob Kim),권병기(Byung-Ki Kwon),이덕희(Duk-Hee Lee) 전력전자학회 2012 전력전자학술대회 논문집 Vol.2012 No.7

대구 중앙로 대중교통전용지구

김윤제(Kim yun che),지형구(Jee hyung koo),최신현(Choi shin hyun) 현대건축사 2008 월간 CONCEPT Vol.- No.109

연료전지용 대용량 PCS의 독립운전 제어기법

Yun-Hyun Kim(김윤현),Chang-Jin Lim(임창진),Kwang-Seob Kim(김광섭) 전력전자학회 2010 전력전자학술대회 논문집 Vol.2010 No.7

연료전지용 대용량 PCS는 다수의 인버터가 병렬로 구성되어 있으며, 계통에 연계하여 운전하거나 혹은 계통에 이상이 발생할 경우 독립운전모드로 운전해야 한다. 독립운전모드로 동작할 경우 각 인버터의 전류가 달라 불평형이 발생할 수 있으므로 부하 분담 제어가 필요하다. 본 논문에서는 부하 임피던스를 추정하여 각 인버터의 출력 지령을 계산하여 출력 전압을 제어하는 알고리즘을 제안하고, 시험을 통해 검증하였다. Master 인버터는 출력 주파수 및 전압을 제어하며, Slave 인버터는 PLL을 이용하여 출력 주파수를 추종하여 전류제어를 수행한다. 제안한 알고리즘을 검증하기 위해 대용량 PCS의 성능 검증장치를 구축하고, 제어 성능을 확인하였다.

내부마케팅에 대한 경영진 헌신이 내부커뮤니케이션에 그리고 이 내부커뮤니케이션이 종사원의 조직시민행동과 고객지향행동에 미치는 영향

김윤형 ( Yun Hyung Kim ),하동현 ( Dong Hyun Ha ) 대한관광경영학회 2015 觀光硏究 Vol.30 No.6

본 연구의 목적은 첫째, 호텔기업을 대상으로 종사원의 관점에서 내부마케팅에 대한 경영진의 헌신이 공식적 및 비공식적 내부커뮤니케이션에 어떻게 영향을 미치는지, 둘째, 공식적 및 비공식적 내부커뮤니케이션 각각이 조직시민행동과 고객지향행동 각각에 어떻게 영향을 미치는지를 파악하고자 하였다. 이러한 연구목적을 달성하기 위하여, 경주와 대구의 특급호텔에 근무하고 있는 종사원을 대상으로, 편의추출법을 사용하여 자료를 수집하였다. 본 연구의 설문조사는 2015년 7월 1일부터 7월 22일까지 22일간 총 300부의 설문지를 배포하여 회수된 설문지 중에서 불성실한 응답을 한 14부를 제외한 286부의 설문지를 분석에 이용하였다. 분석결과는 다음과 같다. 첫째, 내부마케팅에의 경영진의 헌신이 공식적 및 비공식적내부커뮤니케이션에 정(+)의 영향을 미치는 것으로 나타났으며, 둘째, 공식적 및 비공식적내부커뮤니케이션 각각이 조직시민행동과 고객지향행동 각각 정(+)의 영향을 미치는 것으로 나타났다. 본 연구는 선행연구를 이론적으로 확대하여, 내부마케팅에 대한 경영진의 헌신이 공식적 및 비공식적 내부커뮤니케이션을 거쳐 조직시민행동과 고객지향성으로 연결되는 영향관계를 파악하였고, 실무적으로는 성공적인 호텔경영에 필수적인 내부마케팅을 활성화하여 호텔경영진의 목표달성에 도움을 주는 정보를 제공하고자 하였다는 점에서 의의가 있다고 하겠다. This study examines the effect of management commitment to internal marketing on formal and informal internal communication. This research also investigates the causal relationship of the internal communications on organizational citizenship behavior and customer-oriented behavior. Data were collected from 286 full-time employees of five-star hotels in Daegu and Gyeongju with convenient sampling method and sampling period was from July 1 to July 22. The results of structural equation modeling showed that management commitment to internal marketing related to internal marketing practices including formal and informal internal communications, while formal and informal internal communication affected organizational citizenship behavior and customer-oriented behavior. These results implies that hotel management are strongly advised to implement internal marketing to achieve profit and sales growth objectives. Internal marketing practices are material to successful operations of hotel. The current study contributes to a deeper understanding of the internal service-profit chain.

호텔산업에서 내부커뮤니케이션이 리더-부하 간의 교환관계(LMX)와 종사원 업무태도에 미치는 영향

김윤형(Yun-Hyung Kim),하동현(Dong-Hyun Ha) 한국관광연구학회 2016 관광연구저널 Vol.30 No.7

치은 각화상피세포와 섬유아세포를 이용한 삼차원적 배양시 중층화 동안의 변화

정태흡,현하나,김윤상,김은철,유형근,신형식,Jung, Tae-Heup,Hyun, Ha-Na,Kim, Yun-Sang,Kim, Eun-Cheol,You, Hyung-Keun,Shin, Hyung-Shik 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.1

Epithelial-mesenchymal interaction plays a important role in cell growth and differentiation. This interaction is already well known to have an importance during the organ development as well as cell growth and differentiation. However, in vitro experimental model is not well developed to reproduce in vivo cellular microenvironment which provide a epithelial-mesenchymal interaction. Because conventional monolayer culture lacks epithelial-mensenchymal interaction, cultivated cells have an morphologic, biochemical, and functional characteristics differ from in vivo tissue. Moreover, it's condition is not able to induce cellular differention due to submerged culture condition. Therefore, the aims of this study were to develop and evaualte the in vitro experimental model that maintains epithelial-mesenchymal interaction by organotypic raft culture, and to characterize biologic properties of three-dimensionally reconstituted oral keratinocytes by histological and immunohistochemical analysis. The results were as follow; 1. Gingival keratinocytes reconstituted by three-dimensional organotypic culture revealed similar morphologic characteristics to biopsied patient specimen showing stratification, hyperkeratinosis, matutation of epithelial architecture. 2. Connective tissue structure was matured, and there is no difference during stratification period of epithelial 3-dimensional culture. 3. The longer of air-exposure culture on three-dimensionally reconstituted cells, the more epithelial maturation, increased epithelial thickness and surface keratinization 4. In reconstitued mucosa, the whole epidermis was positively stained by anti-involucrin antibody, and there is no difference according to air-exposured culture period. 5. The Hsp was expressed in the epithelial layer of three-dimensionally cultured cells, especially basal layer of epidermis. The change of Hsp expression was not significant by culture stratification. 6. Connexin 43, marker of cell-cell communication was revealed mild immunodeposition in reconstitued epithelium, and there is no significant expression change during stratification. These results suggest that three-dimensional oragnotypic co-culture of normal gingival keratinocytes with dermal equivalent consisting type I collagen and gingival fibroblasts results in similar morphologic and immunohistochemical characteristics to in vivo patient specimens. And this culture system seems to provide adequate micro-environment for in vitro tissue reconstitution. Therefore, further study will be focused to study of in vitro gingivitis model, development of novel perioodntal disease therapeutics and epithelial-mensenchymal interaction.