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Yagi Kiyoshi,Goto Yuta,Kato Kenji,Suzuki Nobuyuki,Kondo Akira,Waseda Yuya,Mizutani Jun,Kawaguchi Yohei,Joyo Yuji,Waguri-Nagaya Yuko,Murakami Hideki 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.6
Study Design Human ligamentum flavum–derived cells (HFCs) were obtained from surgical samples for a basic experimental study. Purpose We sought to evaluate the inflammatory response of human ligamentum flavum cells to investigate hypertrophic changes occurring in the ligamentum flavum. Overview of Literature Lumbar spinal stenosis (LSS) is a disease commonly observed in the elderly. The number of patients with LSS has increased over time, yet the pathomechanisms of LSS still have not been fully elucidated. One of the clinical features of LSS is hypertrophy of the ligamentum flavum, which results in narrowing of the lumbar spinal canal. Some reports have suggested that ligamentum flavum hypertrophy is associated with inflammation and fibrosis; meanwhile, the p38 mitogen-activated protein (MAP) kinase is involved in the hypertrophy of human ligamentum flavum cells. Methods HFCs were obtained from patients with LSS who underwent surgery. HFCs were stimulated by tumor necrosis factor-α (TNF-α) and a p38 MAP kinase inhibitor, SB203580. Phosphorylation of the p38 MAP kinase was analyzed by western blotting. The concentration of interleukin-6 (IL-6) in the conditioned medium was measured by enzyme-linked immunoassay and IL-6 messenger RNA expression levels were determined by real-time polymerase chain reaction. Results TNF-α induced the phosphorylation of p38 MAP kinase in a time-dependent manner, which was suppressed by the p38 MAP kinase inhibitor, SB203580. TNF-α also stimulated IL-6 release in both a time- and dose-dependent manner. On its own, SB203580 did not stimulate IL-6 secretion from HFCs; however, it dramatically suppressed the degree of IL-6 release stimulated by TNF-α from HFCs. Conclusions This is the first report suggesting that TNF-α stimulates the gene expression and protein secretion of IL-6 via p38 MAP kinase in HFCs. A noted association between tissue hypertrophy and inflammation suggests that the p38 MAP kinase inflammatory pathway may be a therapeutic molecular target for LSS.
Abdel-aziz Khairy Abdel-aal,Yuji Yagi 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.2
We estimated moment tensor and centroid depth of eight small/moderate local earthquakes occurred between 2011 and 2013 in the northern Red Sea Triple Junction using a moment tensor inversion of near-source waveform data recorded by very broadband stations of the Egyptian National Seismic Network (ENSN). We also estimated the focal mechanism using the P-wave polarity data set and then compared it with the moment tensor inversion results. The moment tensor solutions are consistent with the focal mechanism obtained from the P-wave polarity data. We also estimated the stress field in the study area using the Multiple Inverse Method (MIM). Our results indicate that the axis of the minimum principal stress is a nearly horizontal NE-SW direction, while the axis of the maximum principal stress is nearly vertical. The direction of the minimum principal stress is consistent with the opening direction of the northern Red Sea zone, where the southern part of Gulf of Suez is currently under an extensional stress field with a NE-SW trending horizontal extension. These results are compatible with the kinematics of the Red Sea-Gulf of Suez rift.