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Suo, Chen,Hrydziuszko, Olga,Lee, Donghwan,Pramana, Setia,Saputra, Dhany,Joshi, Himanshu,Calza, Stefano,Pawitan, Yudi Oxford University Press 2015 Bioinformatics Vol.31 No.16
<P><B>Motivation:</B> Genome and transcriptome analyses can be used to explore cancers comprehensively, and it is increasingly common to have multiple omics data measured from each individual. Furthermore, there are rich functional data such as predicted impact of mutations on protein coding and gene/protein networks. However, integration of the complex information across the different omics and functional data is still challenging. Clinical validation, particularly based on patient outcomes such as survival, is important for assessing the relevance of the integrated information and for comparing different procedures.</P><P><B>Results:</B> An analysis pipeline is built for integrating genomic and transcriptomic alterations from whole-exome and RNA sequence data and functional data from protein function prediction and gene interaction networks. The method accumulates evidence for the functional implications of mutated potential driver genes found within and across patients. A driver-gene score (DGscore) is developed to capture the cumulative effect of such genes. To contribute to the score, a gene has to be frequently mutated, with high or moderate mutational impact at protein level, exhibiting an extreme expression and functionally linked to many differentially expressed neighbors in the functional gene network. The pipeline is applied to 60 matched tumor and normal samples of the same patient from The Cancer Genome Atlas breast-cancer project. In clinical validation, patients with high DGscores have worse survival than those with low scores (<I>P</I> = 0.001). Furthermore, the DGscore outperforms the established expression-based signatures MammaPrint and PAM50 in predicting patient survival. In conclusion, integration of mutation, expression and functional data allows identification of clinically relevant potential driver genes in cancer.</P><P><B>Availability and implementation:</B> The documented pipeline including annotated sample scripts can be found in http://fafner.meb.ki.se/biostatwiki/driver-genes/.</P><P><B>Contact:</B> yudi.pawitan@ki.se</P><P><B>Supplementary information:</B> Supplementary data are available at <I>Bioinformatics</I> online.</P>
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Anti-biofouling Coating by Wrinkled, Dual-roughness Structures of Diamond-like Carbon (DLC)
Yudi Rahmawan,문명원,이광렬,서갑양,장경진 한국바이오칩학회 2009 BioChip Journal Vol.3 No.2
The textured surface with superhydrophobic nature was explored for an anti-biofouling template. Hierarchical structures composed of the nano-scale wrinkle covering on micro-scale polymer pillar patterns were fabricated by combining the deposition of a thin coating layer of biocompatible diamond-like carbon (DLC) and the replica molding of poly-(dimethylsiloxane) (PDMS) micro-pillars. The as- prepared surfaces were shown to have extreme hydrophobicity (static contact angle>160<sup>o</sup>) owing to low surface energy (24.2 mN/m) and dual- roughness structures of the DLC coating. It was explored that the hierarchical surfaces showed poor adhesion of the Calf Pulmonary Artery Endothelial (CPAE) cells for cultures of 7 days suggesting that the 3-dimensional (3-D) patterned superhydrophobic DLC coating exhibits excellent anti-biofouling properties against non-specific cell adhesion. In particular, the reduced filopodia extension during cell growth was caused by disconnected focal adhesions on the pillar pattern. This limited cell adhesion could prevent undesired growth and proliferation of biological species on the surface of biomedical devices such as stents, implants or even injection syringes.
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Yudi Prayudi,Tri K Priyambodo 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.6
The authenticity and the integrity of digital evidence are critical issues in digital forensics activities. Both aspects are directly related to the application of The Locard Exchange Principle (LEP), which is a basic principle of the existence of evidence in an event. This principle, not only applies before and at the time the event occurs, but also applies to the investigation process. In the handling of digital evidence, all activities to access the digital evidence are not likely to occur without the mediation of a set of instruments or applications, whereas every application is made possible for the existence of bugs. In addition, the presence of illegal access to the system, malicious software as well as vulnerabilities of a computer system are a number of potential problems that can have an impact on the change in the authenticity and the integrity of digital evidence. If this is the case, secure and trust characteristics that should appear in the activity of digital forensics may be reduced. This paper tries to discuss how the concept of a secure and trusted environment can be applied to maintain the authenticity and integrity of digital evidence. The proposed concept includes the unity of five components, namely standard and forensics policy, security policy, model and trusted management system, trusted computing, secure channel communication, and human factor. The ultimate purpose of this paper is to provide an overview of how the recommendation can be applied to meet the requirements of a secure and trusted environment in digital forensics for keeping the authenticity and the integrity of digital evidence. In general, this paper tends to explain a high-level concept and does not discuss low-level implementation of a secure and trusted environment.
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Lifestyle Segmentation: The Comparison of Islamic and Conventional Banking Customers in Indonesia
Yudi Sutarso,Elly Rustiana,Rizky Amalia Hanum,Gunawan Wibiksono K 한국유통과학회 2012 유통과학연구 Vol.10 No.8
Understanding customer’ lifestyles important for banks because it will guide in determining marketing policies, such as services, pricing, service delivery and promotion decisions. From the customer’ lifestyle, banks will know what kind of customers’ attitudes, interests and opinions, so they also will understand what the costumer’ needs and what services needed by them. For Islamic banks, customers understanding are important because, nowadays, the competition of the banks is not only with other Islamic banks but also with the well-established conventional banks offering Islamic products or services The aims of this research paper are to describe what factors underline the customer’s lifestyle of both Islamic and conventional bank, to segment the bank customers based on their lifestyles and investigate the profile of each segments, to compare the characteristics of the segments, and to identify marketing policies based on the characteristics. The population of the study is banking customers in Indonesia, in which the researchers have used judgment sampling as sample selection. There were 186 customers of Islamic banks and 244 customers of conventional bank as respondents in this study. Statistical methods employed were exploratory factor analysis and cluster analysis. The finding of the study shows that there are twelve factor underlining the customers’ lifestyle, namely: factor of fashion conscious, internet usage, sports spectator, financial and technology optimism, price sensitivity, independent, compulsive housekeeper, new brand tryer community activities, opinion leader, credit usage, and homebody. In addition, for Islamic banking, there are two market segments, namely fashionable-independent and innovative-social segment. Based on the lifestyle characteristics, the first segment has higher level in factor of fashion conscious, homebody, independent, optimism and price conscious, which is therefore called fashionable-independent segment. On the other hand, the second cluster has higher level in factor of new brand tryer, community minded, sport spectator, credit user, internet usage, opinion leader, and compulsive housekeeper, which is therefore called the innovative-social segment. Furthermore, for conventional banking, there are also two segments, namely persuasive-optimistic and sensitive-independent segment. The first segment has higher level on some factors, namely: opinion leader, optimism, internet usage rate, credit usage level, sport spectator, and new brand tryer. On the other hand, the second cluster is characterized by higher level in factor of price conscious, confidence, community minded, homebody, fashion conscious, and compulsive housekeeper. Managerial implications for the management of Islamic banks could be identified in this study as follows. Firstly, the twelve lifestyle factors of this study could be an alternative view in observe Islamic banking customers. The domination of both the fashionable conscious and the internet usage factor show that the aspects are quite instrumental in perceiving the customer’ lifestyles, in which reflects the importance of these two aspects to customers. Secondly, in serving their customers, Islamic banks need to understand the customer lifestyle, in which the lifestyle segments found in this study provide a guide of how their needs were reflected. Finally, by understanding the segments and the characteristics each segment of the conventional banks, Islamic banks could adjust their marketing strategies differently from the conventional banks.
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Preparation of N-TiO2/RGO nanocomposites through sol-gel method
Yudi Ma,Shukun Wang,Wanlan Zheng,Xin Xue,Huie Liu,Shuang Chen,Yiwen Zhu 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.9
Nitrogen-doped TiO2 and reduced graphene oxide (RGO) nanocomposites (NTG) were prepared by solgel method followed by annealing treatment process under N2 atmosphere. The as-prepared NTG nanocomposite were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FT-IR) and ultraviolet-visible diffuse reflectance spectroscopy (DRS). The results indicate that the incorporation of nitrogen onto both RGO and TiO2 was accomplished simultaneously in the facile process. Nitrogen doping makes the light excitation range red shift and can enhance the electron-hole separation effectively. The photocatalytic activity of the as-prepared samples was evaluated through the degradation of methyl orange (MO) under visible light irradiation. The introduction of nitrogen increased the photodegradation activity, which can be indicated by the fitted apparent first-order kinetics rate constant k, increasing about four times from 0- NTG-450 to 15-NTG-450. The annealing treatment further increased the photodegradation activity about 1.5 times of 15NTG-450 for 15NTG-800.
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Yudi Priyadi,Krishna Kusumahadi,Pramoedya Syachrizalhaq Lyanda 한국지능시스템학회 2022 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.22 No.4
Systems thinking is a discipline for understanding wholeness and frameworks based on thechanging patterns of the interconnectedness of the whole system. The storytelling of a systemis a description of the mental model of an individual in describing the state of the environment. There are differences in the interpretation of the system description. This difference occursbecause each individual has a different level of systems thinking in terms of experience,learning process, insight, intuition, and assumption in understanding system interactions. Thisstudy aims to extract data in the description of the storytelling of a systems thinking caseby performing text mining and similarity to identify and find a variable to form causal loopdiagrams. Based on the results of this study, there are results in the data extraction from thedescription of storytelling for the systems thinking case. The conclusions of this study areas follows: First, processing the five documents has successfully identified two documentswith the highest similarity value, such as d1 and d3. Second, based on the cosine similaritycalculation results and the results of the similarity value, there is a value closest to 1, such as0.0913166. This value is at the d1 and d3 positions. Third, it produces a variable approach inthe form of a group of words used in modeling thinking systems based on a connectednessvalue greater than 0.50.
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Lifestyle Segmentation : The Comparison Of Islamic and Conventional Banking Customers in Indonesia
Yudi Sutarso,Elly Rustiana,Rizky Amalia Hanum,Gunawan Wibiksono K 한국유통과학회 2012 KODISA ICBE (International Conference on Business Vol.2012 No.-
Understanding customer’ lifestyle is important for banks because it will guide in determining marketing policy, such as decision of products or services, pricing, service delivery and promotion. From the customer’ lifestyle, banks will know what kind of customers’ attitudes, interests and opinions, so they also will understand both what the costumer’ needs and what services needed by them. This study aims to determine the grouping of Islamic banking customers, based on their lifestyle. The study used the population of banking customer in Indonesia, in which the sample selection is conducted by a judgment sampling. The number of respondents was 186 customers of Islamic banks and as a comparison there were 244 customers of conventional bank. Statistical methods used in this study were exploratory factor analysis and cluster analysis. The finding of the study shows there are twelve factor underlining the customers’ lifestyle, i.e. factor of fashion conscious, internet usage, sports spectator, financial and technology optimism, price sensitivity, independent, compulsive housekeeper, new brand tryer community activities, opinion leader, credit usage, and homebody. Also, the other finding is there are two market segments for Islamic banking, namely fashionable-independent and innovative-social segment. Furthermore, there are two segments for conventional banking, namely persuasive-optimistic and sensitive-independent. Marketing implications for the segments will also be discussed in the paper.
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